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22-01-2018 | Image

Figure 1 : Mechanisms of protein diversity and consequences for the immune system.

a | Protein diversity is dependent on genetic code (DNA), transcription, translation and, most importantly, post-translational modification. These factors can affect the function, diversity and half-life of the final protein. b | Potential post-translational modification of proteins can define three important characteristics of biologic agents: pharmacokinetics, pharmacodynamics and immunogenicity. All these parameters should be assessed at specific stages of the clinical development of biosimilar agents.

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