05-06-2017 | Image
Figure 1: Overview of the JAK–STAT signaling pathway
Binding of cytokines (yellow) to their receptors on the cell surface results in Janus kinase (JAK) activation and subsequent cross-phosphorylation of the receptors. Signal transducers and activators of transcription (STATs) then attach to the phosphorylated receptors, dimerize, and translocate to the nucleus where they drive the expression of proteins involved in inflammatory processes, including those leading to autoimmune diseases such as rheumatoid arthritis.
Adapted from