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The median time from the start of therapy to reaction was 30 days, and 90% of reactions occurred within 180 days. Reproduced with permission from Stamp, L. K. et al. Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol. Arthritis Rheum. 64, 2529–2536(2012) © 2012, American College of Rheumatology.