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Reproduced from Stamp, L. K. et al. Allopurinol and kidney function: an update. Joint Bone Spine 90, 19–24 (2016). Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level. Clin. Pharm. Ther. 90, 392–398 (2011) © American Society for Clinical Pharmacology and Therapeutics.