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Gout and crystal arthropathies

Pathophysiology

Calcium crystal deposition diseases: Beyond gout

In this review, the main clinical manifestations of calcium pyrophosphate dihydrate and basic calcium phosphate crystal deposition are discussed, along with the biological effects of these crystals, current therapeutic approaches and future directions in therapy [read more].
McCarthy GM, Dunne A. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0078-5

06-09-2018 | Calcium crystal deposition disease | Review | Article

Calcium crystal deposition diseases: Beyond gout

McCarthy GM, Dunne A. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0078-5

06-07-2018 | Gout | Article

Next-generation sequencing profiling of mitochondrial genomes in gout

Tseng CC et al. Arthritis Res Ther 2018; 20: 137. doi: 10.1186/s13075-018-1637-5

05-07-2018 | Gout | Article

Mediation analysis to understand genetic relationships between habitual coffee intake and gout

Hutton J et al. Arthritis Res Ther 2018; 20: 135. doi: 10.1186/s13075-018-1629-5

04-06-2018 | Inflammation | Review | Article

Novel insights into the role of inflammasomes in autoimmune and metabolic rheumatic diseases

Deuteraiou K et al. Rheumatol Int 2018. doi: 10.1007/s00296-018-4074-5

15-05-2018 | Osteoarthritis | Review | Article

Defining the osteoarthritis patient: Back to the future

Dobson GP et al. Osteoarthritis Cartilage 2018. doi: 10.1016/j.joca.2018.04.018

08-05-2018 | Gout | Review | Article

An update on the genetics of hyperuricemia and gout

Major TJ et al. Nat Rev Rheumatol 2018; Advance online publication. doi: 10.1038/s41584-018-0004-x

21-03-2018 | Pathogenesis | Review | Article

Type I interferon in rheumatic diseases

Wampler TL, Niewold TB. Nat Rev Rheumatol 2018; 14: 214–228. doi: 10.1038/nrrheum.2018.31

08-03-2018 | Osteoarthritis | Review | Article

Calcium-containing crystals and osteoarthritis: An unhealthy alliance

Conway R, McCarthy GM. Curr Rheumatol Rep 2018; 20: 13. doi: 10.1007/s11926-018-0721-9

15-06-2017 | Genetics | Review | Article

Why location matters: Site-specific factors in rheumatic diseases

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

Authors:
Caroline Ospelt, Mojca Frank-Bertoncelj

31-05-2017 | Gout | Review | Article

The genetics of gout: Toward personalized medicine?

The authors review the current knowledge generated by genome-wide association studies, and discuss the translation of these findings into integrated personalized medicine approaches for hyperuricemia and gout.

Dalbeth N, Stamp LK, Merriman TR. BMC Med 2017;15:108. doi:10.1186/s12916-017-0878-5

29-09-2016 | Gout | Review | Article

Gout and osteoarthritis: Associations, pathophysiology, and therapeutic implications

This review provides an overview of possible biochemical, mechanical, and immunological relationships between gout and osteoarthritis, and the implications of these relationships for treatment.

Yokose C et al. Curr Rheumatol Rep 2016;18:65. doi:10.1007/s11926-016-0613-9

22-04-2016 | Gout | Article

Urate handling in the human body

This paper provides an overview of the ways in which urate is handled by the human body, in terms of production, renal elimination and intestinal elimination.

Hyndman D, Liu S, Miner JN. Curr Rheumatol Rep. 2016;18:34. doi: 10.1007/s11926-016-0587-7.

14-10-2015 | Gout | Article

Factors influencing the crystallization of monosodium urate: a systematic literature review

This systematic literature review was conducted to identify factors contributing to monosodium urate (MSU) crystallization in gout.

Chhana A, Lee G, Dalbeth N. BMC Musculoskel Disord. 2015;16:296. doi: 10.1186/s12891-015-0762-4.

15-09-2015 | Gout | Review | Article

Mechanisms of crystal formation in gout—a structural approach

This analysis supports the concept of gout as a persistent crystal deposition disease and suggests new research pathways that might promote initial crystal nucleation and growth on fibres after damage or alteration.

Nat Rev Rheumatol 2015;11:725–730. doi:10.1038/nrrheum.2015.125

Authors:
Eliseo Pascual, Lia Addadi, Mariano Andrés, Francisca Sivera

30-05-2014 | Gout | Book Chapter | Article

Physiopathology of gout

This chapter provides an overview of gout, in terms of genetics, mechanisms of disease, and the inflammation and joint damage that occurs, as well as a discussion of the association between the chronic inflammation in gout and cardiovascular outcomes.

Managing gout in primary care. Springer Healthcare, London. 2014:13–24. doi: 10.1007/978-1-907673-67-2.

Authors:
Fernando Pérez-Ruiz, Edwin Castillo

11-01-2013 | Gout | Review | Article

Genetics of hyperuricemia and gout: Implications for the present and future

Genome-wide association studies have identified several new and common genetic factors that contribute to hyperuricemia and gout. This review examines the role of genetics in the development of gout.

George RL & Keenan RT. Curr Rheumatol Rep 2013;15:309. doi:10.1007/s11926-012-0309-8

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