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14-03-2017 | Gout | Article

Sex differences in gout characteristics: tailoring care for women and men

BMC Musculoskeletal Disorders

Authors: Leslie R. Harrold, Carol J. Etzel, Allan Gibofsky, Joel M. Kremer, Michael H. Pillinger, Kenneth G. Saag, Naomi Schlesinger, Robert Terkeltaub, Vanessa Cox, Jeffrey D. Greenberg

Publisher: BioMed Central



To characterize the differences between women and men with gout.


We analyzed a US national cohort of gout patients cared for by rheumatologists.


Compared with the 1012 men with gout, women with gout (n = 262) were older (71 vs. 61 years, p < 0.001) and had a greater burden of comorbid conditions (p < 0.001 for hypertension, diabetes, renal disease and obesity). Risk factors for gout differed with women more often taking diuretics (p < 0.001), while men more frequently had dietary triggers (p < 0.05).


The profiles of women and men with gout are markedly different, suggesting a need to tailor treatment recommendations.

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