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29-09-2016 | Gout | Review | Article

Gout and Osteoarthritis: Associations, Pathophysiology, and Therapeutic Implications

Journal:
Current Rheumatology Reports

Authors: Chio Yokose, Meng Chen, Adey Berhanu, Michael H. Pillinger, Svetlana Krasnokutsky

Publisher: Springer US

Abstract

Osteoarthritis (OA), the most common type of arthritis worldwide, is a degenerative disease of diarthrodial joints resulting in pain, reduced quality of life, and socioeconomic burden. Gout, the most common form of inflammatory arthritis, is a consequence of persistently elevated levels of urate and the formation of proinflammatory monosodium urate crystals in joints. Clinicians have long noted a predilection for both diseases to occur in the same joints. In this review, we provide an overview into research elucidating possible biochemical, mechanical, and immunological relationships between gout and OA. We additionally consider the potential implications of these relationships for OA treatment.

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