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02-04-2018 | Granulomatosis with polyangiitis | Article

Eosinophilic Granulomatosis With Polyangiitis: Newer Therapies

Journal:
Current Rheumatology Reports

Authors: Erika P. Navarro-Mendoza, Gabriel J. Tobón

Publisher: Springer US

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disseminated vasculitis associated with extravascular granulomas in patients suffering from asthma and tissue eosinophilia. Current therapies to achieve remission and prevent relapse include glucocorticoids and immunosuppressants like cyclophosphamide.
With the right treatment, clinical prognosis is favorable, so concerted efforts have been made in recent years to find new alternatives for treating severe EGPA. Monoclonal antibodies such as omalizumab, rituximab, and mepolizumab are among these new options.
This review summarizes the pathogenesis and clinical manifestations of EGPA and critically examines current and emerging therapies.

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