Skip to main content
Top

04-08-2017 | Juvenile idiopathic arthritis | Review | Article

Ultrasound imaging of synovial inflammation in juvenile idiopathic arthritis

Journal: Pediatric Radiology

Authors: Nancy A. Chauvin, Andrea S. Doria

Publisher: Springer Berlin Heidelberg

Abstract

Juvenile idiopathic arthritis (JIA) is the most common rheumatic entity of childhood. The hallmark feature of all subtypes is joint inflammation. Imaging is used to evaluate the extent and severity of inflammation, degree of joint damage and response to treatment, which in turn impacts patient management. Ultrasound has become a useful adjunct to clinical examination because it shows promise in evaluating clinical and subclinical inflammation (synovitis, enthesitis) as well as cartilage and bone erosive changes. However more collaborative research is needed to help define the normal appearance of the growing skeleton, clarify the significance of subclinical findings and develop useful definitions, imaging protocols and scoring systems of disease.
Literature
1.
Ording Muller LS, Humphries P, Rosendahl K (2015) The joints in juvenile idiopathic arthritis. Insights Imaging 6:275–284CrossRefPubMedPubMedCentral
2.
Sheybani EF, Khanna G, White AJ et al (2013) Imaging of juvenile idiopathic arthritis: a multimodality approach. Radiographics 33:1253–1273CrossRefPubMed
3.
Magni-Manzoni S (2016) Ultrasound in juvenile idiopathic arthritis. Pediatr Rheumatol Online J 14:33CrossRefPubMedPubMedCentral
4.
Magni-Manzoni S, Malattia C, Lanni S et al (2012) Advances and challenges in imaging in juvenile idiopathic arthritis. Nat Rev Rheumatol 8:329–336CrossRefPubMed
5.
Petty RE, Southwood TR, Manners P et al (2004) International League of Associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392PubMed
6.
Ravelli A, Martini A (2007) Juvenile idiopathic arthritis. Lancet 369:767–778CrossRefPubMed
7.
Ramos PC, Ceccarelli F, Jousse-Joulin S (2012) Role of ultrasound in the assessment of juvenile idiopathic arthritis. Rheumatology 51:vii10–12
8.
Prakken B, Albani S, Martini A (2011) Juvenile idiopathic arthritis. Lancet 377:2138–2149CrossRefPubMed
9.
Pruthi S, Thapa MM (2009) Infectious and inflammatory disorders. Magn Reson Imaging Clin N Am 17:423–438CrossRefPubMed
10.
Miller E, Doria AS (2010) Imaging for early assessment of peripheral joints in juvenile idiopathic arthritis. In: Medina LS, Applegate KE, Blackmore CC (eds) Evidence-based imaging in pediatrics: improving the quality of imaging in patient care. Springer, New York, pp 219–244CrossRef
11.
Collado P, Jousse-Joulin S, Alcalde M et al (2012) Is ultrasound a validated imaging tool for the diagnosis and management of synovitis in juvenile idiopathic arthritis? A systematic literature review. Arthritis Care Res 64:1011–1019
12.
Avenarius DF, Ording Muller LS, Rosendahl K (2016) Erosion or normal variant? 4-year MRI follow-up of the wrists in healthy children. Pediatr Radiol 46:322–330CrossRefPubMed
13.
Roth J, Jousse-Joulin S, Magni-Manzoni S et al (2015) Definitions for the sonographic features of joints in healthy children. Arthritis Care Res 67:136–142CrossRef
14.
Chauvin NA, Ho-Fung V, Jaramillo D et al (2015) Ultrasound of the joints and entheses in healthy children. Pediatr Radiol 45:1344–1354CrossRefPubMed
15.
Keshava SN, Gibikote SV, Mohanta A et al (2015) Ultrasound and magnetic resonance imaging of healthy paediatric ankles and knees: a baseline for comparison with haemophilic joints. Haemophilia 21:e210–e222CrossRefPubMed
16.
Spannow AH, Pfeiffer-Jensen M, Andersen NT et al (2010) Ultrasonographic measurements of joint cartilage thickness in healthy children: age- and sex-related standard reference values. J Rheumatol 37:2595–2601CrossRefPubMed
17.
Spannow AH, Stenboeg E, Pfeiffer-Jensen M et al (2011) Ultrasound and MRI measurements of joint cartilage in healthy children: a validation study. Ultraschall Med 32:S110–S116CrossRefPubMed
18.
Tse SM, Laxer RM, Babyn PS et al (2006) Radiologic improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. J Rheumatol 33:1186–1188PubMed
19.
Visser K, Katchamart W, Loza E et al (2009) Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E initiative. Ann Rheum Dis 68:1086–1093CrossRefPubMed
20.
Roth J, Ravagnani V, Backhaus M et al (2016) Preliminary definitions for the sonographic features of synovitis in children. Arthritis Care Res. doi:10.​1002/​acr.​23130
21.
Moller I, Loza E, Uson J et al (2016) Recommendations for the use of ultrasound and magnetic resonance in patients with rheumatoid arthritis. Reumatol Clin. doi:10.​1016/​j.​reuma.​2016.​08.​010
22.
D'Agostino MA, Conaghan PG, Naredo E et al (2009) The OMERACT ultrasound task force — advances and priorities. J Rheumatol 36:1829–1832CrossRefPubMed
23.
Nusman CM, Ording Muller LS, Hemke R et al (2016) Current status of efforts on standardizing magnetic resonance imaging of juvenile idiopathic arthritis: report from the OMERACT MRI in JIA working group and health-e-child. J Rheumatol 43:239–244CrossRefPubMed
24.
Colebatch-Bourn AN, Edwards CJ, Collado P et al (2015) EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice. Ann Rheum Dis 74:1946–1957CrossRefPubMed
25.
Hemke R, Doria AS, Tzaribachev N et al (2014) Selecting magnetic resonance imaging (MRI) outcome measures for juvenile idiopathic arthritis (JIA) clinical trials: first report of the MRI in JIA special interest group. J Rheumatol 41:354–358CrossRefPubMed
26.
Lee MJ, Chow K (2007) Ultrasound of the knee. Semin Musculoskelet Radiol 11:137–148CrossRefPubMed
27.
Johnson K (2006) Imaging of juvenile idiopathic arthritis. Pediatr Radiol 36:743–758CrossRefPubMed
28.
Doria AS, Kiss MH, Lotito AP et al (2001) Juvenile rheumatoid arthritis of the knee: evaluation with contrast-enhanced color Doppler ultrasound. Pediatr Radiol 31:524–531CrossRefPubMed
29.
Mouterde G, Carotti M, D'Agostino MA (2009) Contrast-enhanced ultrasound in musculoskeletal diseases. J Radiol 90:148–155CrossRefPubMed
30.
Doria AS, Karshafian R, Moineddin R et al (2006) Contrast-enhanced triggered harmonic sonography for assessment of periarticular hemodynamic changes in experimental arthritis. Pediatr Radiol 36:1242–1251CrossRefPubMed
31.
Weiss PF, Chauvin NA, Roth J (2016) Imaging in juvenile spondyloarthritis. Curr Rheumatol Rep 18:75CrossRefPubMed
32.
Magni-Manzoni S, Rossi F, Pistorio A et al (2003) Prognostic factors for radiographic progression, radiographic damage, and disability in juvenile idiopathic arthritis. Arthritis Rheum 48:3509–3517CrossRefPubMed
33.
Hudson JM, Karshafian R, Burns PN (2009) Quantification of flow using ultrasound and microbubbles: a disruption replenishment model based on physical principles. Ultrasound Med Biol 35:2007–2020CrossRefPubMed
34.
Muller L, Kellenberger CJ, Cannizzaro E et al (2009) Early diagnosis of temporomandibular joint involvement in juvenile idiopathic arthritis: a pilot study comparing clinical examination and ultrasound to magnetic resonance imaging. Rheumatology 48:680–685CrossRefPubMedPubMedCentral
35.
Janow GL, Panghaal V, Trinh A et al (2011) Detection of active disease in juvenile idiopathic arthritis: sensitivity and specificity of the physical examination vs ultrasound. J Rheumatol 38:2671–2674CrossRefPubMed
36.
Murphy KJ, Rubin JM (1997) Power Doppler: it's a good thing. Semin Ultrasound CT MR 18:13–21CrossRefPubMed
37.
Krishnamurthy R, Yoo JH, Thapa M et al (2013) Water-bath method for sonographic evaluation of superficial structures of the extremities in children. Pediatr Radiol 43:S41–S47CrossRefPubMed
38.
Bertamino M, Rossi F, Pistorio A et al (2010) Development and initial validation of a radiographic scoring system for the hip in juvenile idiopathic arthritis. J Rheumatol 37:432–439CrossRefPubMed
39.
Bruyn GA, Naredo E, Iagnocco A et al (2015) The OMERACT ultrasound working group 10 years on: update at OMERACT 12. J Rheumatol 42:2172–2176CrossRefPubMed
40.
Wakefield RJ, Balint PV, Szkudlarek M et al (2005) Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol 32:2485–2487PubMed
41.
Tok F, Demirkaya E, Ozcakar L (2011) Musculoskeletal ultrasound in pediatric rheumatology. Pediatr Rheumatol Online J 9:25CrossRefPubMedPubMedCentral
42.
Collado P, Naredo E, Calvo C et al (2007) Assessment of the joint recesses and tendon sheaths in healthy children by high-resolution B-mode and power Doppler sonography. Clin Exp Rheumatol 25:915–921PubMed
43.
Panghaal V, Janow G, Trinh A et al (2012) Normal epiphyseal cartilage measurements in the knee in children: an alternative sonographic approach. J Ultrasound Med 31:49–53CrossRefPubMed
44.
Laurell L, Court-Payen M, Boesen M et al (2013) Imaging in juvenile idiopathic arthritis with a focus on ultrasonography. Clin Exp Rheumatol 31:135–148PubMed
45.
Sheldon PJ, Forrester DM, Learch TJ (2005) Imaging of intraarticular masses. Radiographics 25:105–119CrossRefPubMed
46.
Valle M, Zamorani MP (2007) Bone and joint. In: Bianchi S, Martinoli C (eds) Ultrasound of the musculoskeletal system. Springer, Berlin, p 161
47.
Alessi S, Depaoli R, Canepari M et al (2012) Baker's cyst in pediatric patients: ultrasonographic characteristics. J Ultrasound 15:76–81CrossRefPubMed
48.
Seil R, Rupp S, Jochum P et al (1999) Prevalence of popliteal cysts in children. A sonographic study and review of the literature. Arch Orthop Trauma Surg 119:73–75CrossRefPubMed
49.
Breton S, Jousse-Joulin S, Cangemi C et al (2011) Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis. Semin Arthritis Rheum 41:272–278CrossRefPubMed
50.
Sparchez M, Fodor D, Miu N (2010) The role of power Doppler ultrasonography in comparison with biological markers in the evaluation of disease activity in juvenile idiopathic arthritis. Med Ultrason 12:97–103PubMed
51.
Shahin AA, Shaker OG, Kamal N et al (2002) Circulating interleukin-6, soluble interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-10 levels in juvenile chronic arthritis: correlations with soft tissue vascularity assessed by power Doppler sonography. Rheumatol Int 22:84–88CrossRefPubMed
52.
Torp-Pedersen ST, Terslev L (2008) Settings and artefacts relevant in colour/power Doppler ultrasound in rheumatology. Ann Rheum Dis 67:143–149CrossRefPubMed
53.
Ranjan S, Jahan A, Yadav TP et al (2014) Evaluation of synovial inflammation in juvenile idiopathic arthritis by power color Doppler and spectral Doppler ultrasonography. Indian J Pediatr 81:29–35CrossRefPubMed
54.
Bhagwani DK, Jahan A, Yadav TP et al (2012) Diagnostic sensitivity and specificity of spectral color Doppler ultrasound indices in juvenile idiopathic arthritis. Ann Paediatr Rheum 1:163–170CrossRef
55.
Mandl P, Naredo E, Wakefield RJ et al (2011) A systematic literature review analysis of ultrasound joint count and scoring systems to assess synovitis in rheumatoid arthritis according to the OMERACT filter. J Rheumatol 38:2055–2062CrossRefPubMed
56.
Damasio MB, Malattia C, Martini A et al (2010) Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis. Pediatr Radiol 40:985–998CrossRefPubMed
57.
Ravelli A, Martini A (2003) Early predictors of outcome in juvenile idiopathic arthritis. Clin Exp Rheumatol 21:S89–S93PubMed
58.
Malattia C, Damasio MB, Magnaguagno F et al (2008) Magnetic resonance imaging, ultrasonography, and conventional radiography in the assessment of bone erosions in juvenile idiopathic arthritis. Arthritis Rheum 59:1764–1772CrossRefPubMed
59.
Pradsgaard DO, Spannow AH, Heuck C et al (2013) Decreased cartilage thickness in juvenile idiopathic arthritis assessed by ultrasonography. J Rheumatol 40:1596–1603CrossRefPubMed
60.
Chan MW, Amirabadi A, Man C et al (2012) Techniques and challenges of 3D ultrasound and fusion 3DUS-MR imaging for assessment of knees in juvenile idiopathic arthritis. 98th scientific assembly and annual meeting of the Radiological Society of North America, Chicago, IL