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Myostatin – The Holy Grail for Muscle, Bone, and Fat?

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Abstract

Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, was first described in 1997. Since then, myostatin has gained growing attention because of the discovery that myostatin inhibition leads to muscle mass accrual. Myostatin not only plays a key role in muscle homeostasis, but also affects fat and bone. This review will focus on the impact of myostatin and its inhibition on muscle mass/function, adipose tissue and bone density/geometry in humans. Although existing data are sparse, myostatin inhibition leads to increased lean mass and 1 study found a decrease in fat mass and increase in bone formation. In addition, myostatin levels are increased in sarcopenia, cachexia and bed rest whereas they are increased after resistance training, suggesting physiological regulatory of myostatin. Increased myostatin levels have also been found in obesity and levels decrease after weight loss from caloric restriction. Knowledge on the relationship of myostatin with bone is largely based on animal data where elevated myostatin levels lead to decreased BMD and myostatin inhibition improved BMD. In summary, myostatin appears to be a key factor in the integrated physiology of muscle, fat, and bone. It is unclear whether myostatin directly affects fat and bone, or indirectly via muscle. Whether via direct or indirect effects, myostatin inhibition appears to increase muscle and bone mass and decrease fat tissue—a combination that truly appears to be a holy grail. However, at this time, human data for both efficacy and safety are extremely limited. Moreover, whether increased muscle mass also leads to improved function remains to be determined. Ultimately potential beneficial effects of myostatin inhibition will need to be determined based on hard outcomes such as falls and fractures.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing. 2010;39(4):412–23. doi:10.1093/ageing/afq034. Article proposes a consensus definition for sarcopenia and also gives a concise overview over the sarcopenia syndrome itself.

    Article  PubMed  Google Scholar 

  2. Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011;12(4):249–56.

    Article  PubMed  Google Scholar 

  3. Lang T, Streeper T, Cawthon P, Baldwin K, Taaffe DR, Harris TB. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int. 2010;21(4):543–59. doi:10.1007/s00198-009-1059-y.

    Article  PubMed  CAS  Google Scholar 

  4. Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Sarcopenia in the elderly: diagnosis, physiopathology and treatment. Maturitas. 2012;71(2):109–14. doi:10.1016/j.maturitas.2011.11.012.

    Article  PubMed  Google Scholar 

  5. Muscaritoli M, Anker SD, Argiles J, Aversa Z, Bauer JM, Biolo G, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clin Nutr (Edinburgh, Scotland). 2010;29(2):154–9. doi:10.1016/j.clnu.2009.12.004.

    Article  CAS  Google Scholar 

  6. Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G, et al. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging. 2008;12(7):433–50.

    Article  PubMed  CAS  Google Scholar 

  7. Walston JD. Sarcopenia in older adults. Curr Opin Rheumatol. 2012;24(6):623–7. doi:10.1097/BOR.0b013e328358d59b.

    Article  PubMed  Google Scholar 

  8. Ferrucci L, Russo CR, Lauretani F, Bandinelli S, Guralnik JM. A role for sarcopenia in late-life osteoporosis. Aging Clin Exp Res. 2002;14(1):1–4.

    Article  PubMed  CAS  Google Scholar 

  9. Bijlsma AY, Meskers CG, Westendorp RG, Maier AB. Chronology of age-related disease definitions: osteoporosis and sarcopenia. Ageing Res Rev. 2012;11(2):320–4. doi:10.1016/j.arr.2012.01.001.

    Article  PubMed  CAS  Google Scholar 

  10. • Digirolamo DJ, Kiel DP, Esser KA. Bone and skeletal muscle: neighbors with close ties. J Bone Miner Res. 2013;28(7):1509–18. Article reviews the current data on muscle – bone interactions including genetics and mechanotransduction.

    Article  PubMed  Google Scholar 

  11. Sirola J, Kroger H. Similarities in acquired factors related to postmenopausal osteoporosis and sarcopenia. J Osteoporos. 2011. doi:10.4061/2011/536735.

    Google Scholar 

  12. Baumgartner RN, Wayne SJ, Waters DL, Janssen I, Gallagher D, Morley JE. Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res. 2004;12(12):1995–2004. doi:10.1038/oby.2004.250.

    Article  PubMed  Google Scholar 

  13. Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care. 2008;11(6):693–700. doi:10.1097/MCO.0b013e328312c37d00075197-200811000-00004.

    Article  PubMed  Google Scholar 

  14. Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18(5):388–95. doi:10.1016/j.numecd.2007.10.002.

    Article  PubMed  CAS  Google Scholar 

  15. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone. Nat Clin Pract Rheumatol. 2006;2:35–43.

    Article  PubMed  CAS  Google Scholar 

  16. Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW. Relationship of obesity with osteoporosis. J Clin Endocrinol Metab. 2007;92:1640–6.

    Article  PubMed  CAS  Google Scholar 

  17. Chumlea WC, Cesari M, Evans WJ, Ferrucci L, Fielding RA, Pahor M, et al. Sarcopenia: designing phase IIB trials. J Nutr Health Aging. 2011;15(6):450–5.

    Article  PubMed  Google Scholar 

  18. van Kan Abellan G, Cameron Chumlea W, Gillette-Guyonet S, Houles M, Dupuy C, Rolland Y, et al. Clinical trials on sarcopenia: methodological issues regarding phase 3 trials. Clin Geriatr Med. 2011;27(3):471–82. doi:10.1016/j.cger.2011.03.010.

    Article  Google Scholar 

  19. • Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8(8):45765. doi:10.1038/nrendo.2012.49. Article describes various “myokines” including myostatin and their potential effects on the human body.

    Article  Google Scholar 

  20. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997;387(6628):83–90. doi:10.1038/387083a0.

    Article  PubMed  CAS  Google Scholar 

  21. McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci U S A. 1997;94(23):12457–61.

    Article  PubMed  CAS  Google Scholar 

  22. •• Allen DL, Hittel DS, McPherron AC. Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Med Sci Sports Exerc. 2011;43(10):1828–35. doi:10.1249/MSS.0b013e3182178bb4. Article outlines the physiology of myostatin with particular attention to its role in obesity and diabetes.

    Article  PubMed  CAS  Google Scholar 

  23. Lee SJ. Regulation of muscle mass by myostatin. Annu Rev Cell Dev Biol. 2004;20:61–86. doi:10.1146/annurev.cellbio.20.012103.135836.

    Article  PubMed  CAS  Google Scholar 

  24. •• Elliott B, Renshaw D, Getting S, Mackenzie R. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiol (Oxf). 2012;205(3):324–40. doi:10.1111/j.1748-1716.2012.02423.x. Article gives a great overview over the history of myostatin from its discovery to signaling mechanisms to available animal and human data in muscle and other tissues.

    Article  CAS  Google Scholar 

  25. Argiles JM, Orpi M, Busquets S, Lopez-Soriano FJ. Myostatin: more than just a regulator of muscle mass. Drug Discov Today. 2012;17(13–14):702–9. doi:10.1016/j.drudis.2012.02.001.

    Article  PubMed  CAS  Google Scholar 

  26. McNally EM. Powerful genes–myostatin regulation of human muscle mass. N Engl J Med. 2004;350(26):2642–4. doi:10.1056/NEJMp048124.

    Article  PubMed  CAS  Google Scholar 

  27. Huang Z, Chen X, Chen D. Myostatin: a novel insight into its role in metabolism, signal pathways, and expression regulation. Cell Signal. 2011;23(9):1441–6. doi:10.1016/j.cellsig.2011.05.003.

    Article  PubMed  CAS  Google Scholar 

  28. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, et al. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A. 1998;95(25):14938–43.

    Article  PubMed  CAS  Google Scholar 

  29. Sharma M, Langley B, Bass J, Kambadur R. Myostatin in muscle growth and repair. Exerc Sport Sci Rev. 2001;29(4):155–8.

    Article  PubMed  CAS  Google Scholar 

  30. Lee SJ, Lee YS, Zimmers TA, Soleimani A, Matzuk MM, Tsuchida K, et al. Regulation of muscle mass by follistatin and activins. Mol Endocrinol. 2010;24(10):1998–2008. doi:10.1210/me.2010-0127.

    Article  PubMed  CAS  Google Scholar 

  31. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997;127(5 Suppl):990S–1S.

    PubMed  CAS  Google Scholar 

  32. Reardon KA, Davis J, Kapsa RM, Choong P, Byrne E. Myostatin, insulin-like growth factor-1, and leukemia inhibitory factor mRNAs are upregulated in chronic human disuse muscle atrophy. Muscle Nerve. 2001;24(7):893–9.

    Article  PubMed  CAS  Google Scholar 

  33. Zachwieja JJ, Smith SR, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J Gravit Physiol. 1999;6(2):11–5.

    PubMed  CAS  Google Scholar 

  34. Ju CR, Chen RC. Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease. Respir Med. 2012;106(1):102–8. doi:10.1016/j.rmed.2011.07.016.

    Article  PubMed  Google Scholar 

  35. Remels AH, Gosker HR, Langen RC, Schols AM. The mechanisms of cachexia underlying muscle dysfunction in COPD. J Appl Physiol. 2013;114(9):1253–62. doi:10.1152/japplphysiol.00790.2012.

    Article  PubMed  CAS  Google Scholar 

  36. Han DS, Chen YM, Lin SY, Chang HH, Huang TM, Chi YC, et al. Serum myostatin levels and grip strength in normal subjects and patients on maintenance haemodialysis. Clin Endocrinol (Oxf). 2011;75(6):857–63. doi:10.1111/j.1365-2265.2011.04120.x.

    Article  CAS  Google Scholar 

  37. Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J, Gonzalez-Cadavid NF. Serum myostatin-immunoreactive protein is increased in 60–92 year old women and men with muscle wasting. J Nutr Health Aging. 2002;6(5):343–8.

    PubMed  CAS  Google Scholar 

  38. Leger B, Derave W, De Bock K, Hespel P, Russell AP. Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res. 2008;11(1):163–75B. doi:10.1089/rej.2007.0588.

    Article  PubMed  Google Scholar 

  39. Ratkevicius A, Joyson A, Selmer I, Dhanani T, Grierson C, Tommasi AM, et al. Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men. J Gerontol A Biol Sci Med Sci. 2011;66(6):620–6. doi:10.1093/gerona/glr025.

    Article  PubMed  CAS  Google Scholar 

  40. Szulc P, Schoppet M, Goettsch C, Rauner M, Dschietzig T, Chapurlat R, et al. Endocrine and clinical correlates of myostatin serum concentration in men–the STRAMBO study. J Clin Endocrinol Metab. 2012;97(10):3700–8. doi:10.1210/jc.2012-1273.

    Article  PubMed  CAS  Google Scholar 

  41. Seibert MJ, Xue QL, Fried LP, Walston JD. Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the women's health and aging study II cohort. J Am Geriatr Soc. 2001;49(8):1093–6.

    Article  PubMed  CAS  Google Scholar 

  42. Bhatt SP, Nigam P, Misra A, Guleria R, Luthra K, Jain SK, et al. Association of the Myostatin gene with obesity, abdominal obesity and low lean body mass and in non-diabetic Asian Indians in north India. PLoS One. 2012;7(8):e40977. doi:10.1371/journal.pone.0040977.

    Article  PubMed  CAS  Google Scholar 

  43. Yue H, He JW, Zhang H, Wang C, Hu WW, Gu JM, et al. Contribution of myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring. Acta Pharmacol Sin. 2012;33(5):660–7. doi:10.1038/aps.2012.12.

    Article  PubMed  CAS  Google Scholar 

  44. Garatachea N, Lucia A. Genes and the ageing muscle: a review on genetic association studies. Age (Dordr). 2013;35(1):207–33. doi:10.1007/s11357-011-9327-0.

    Article  CAS  Google Scholar 

  45. Santiago C, Ruiz JR, Rodriguez-Romo G, Fiuza-Luces C, Yvert T, Gonzalez-Freire M, et al. The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men. PLoS One. 2011;6(1):e16323. doi:10.1371/journal.pone.0016323.

    Article  PubMed  CAS  Google Scholar 

  46. Roth SM, Martel GF, Ferrell RE, Metter EJ, Hurley BF, Rogers MA. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood). 2003;6(228):706–9.

    Google Scholar 

  47. Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Mol Cell Endocrinol. 2010;317(1–2):25–30. doi:10.1016/j.mce.2009.12.019.

    Article  PubMed  CAS  Google Scholar 

  48. Walker KS, Kambadur R, Sharma M, Smith HK. Resistance training alters plasma myostatin but not IGF-1 in healthy men. Med Sci Sports Exerc. 2004;36(5):787–93.

    Article  PubMed  CAS  Google Scholar 

  49. Konopka AR, Douglass MD, Kaminsky LA, Jemiolo B, Trappe TA, Trappe S, et al. Molecular adaptations to aerobic exercise training in skeletal muscle of older women. J Gerontol A Biol Sci Med Sci. 2010;65(11):1201–7. doi:10.1093/gerona/glq109.

    Article  PubMed  Google Scholar 

  50. Hittel DS, Axelson M, Sarna N, Shearer J, Huffman KM, Kraus WE. Myostatin decreases with aerobic exercise and associates with insulin resistance. Med Sci Sports Exerc. 2010;42(11):2023–9. doi:10.1249/MSS.0b013e3181e0b9a8.

    Article  PubMed  CAS  Google Scholar 

  51. Hulmi JJ, Ahtiainen JP, Kaasalainen T, Pollanen E, Hakkinen K, Alen M, et al. Postexercise myostatin and activin IIb mRNA levels: effects of strength training. Med Sci Sports Exerc. 2007;39(2):289–97. doi:10.1249/01.mss.0000241650.15006.6e.

    Article  PubMed  CAS  Google Scholar 

  52. Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W, et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med. 2004;350(26):2682–8. doi:10.1056/NEJMoa040933.

    Article  PubMed  CAS  Google Scholar 

  53. Fedoruk MN, Rupert JL. Myostatin inhibition: a potential performance enhancement strategy? Scand J Med Sci Sports. 2008;18(2):123–31. doi:10.1111/j.1600-0838.2007.00759.x.

    Article  PubMed  CAS  Google Scholar 

  54. Krivickas LS, Walsh R, Amato AA. Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO-029. Muscle Nerve. 2009;39(1):3–9. doi:10.1002/mus.21200.

    Article  PubMed  CAS  Google Scholar 

  55. • Attie KM, Borgstein NG, Yang Y, Condon CH, Wilson DM, Pearsall AE, et al. A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013;47(3):416–23. doi:10.1002/mus.23539. Only currently available human randomized controlled trial on myostatin pathway inhibition and its effect on muscle, fat, and bone.

    Article  PubMed  CAS  Google Scholar 

  56. Borgstein NG, Barger R, Yang Y, Wilson DM, Haltom E, Attie KM, et al. A Phase 1 multiple ascending dose study to assess the pharma-codynamic effects of ACE-031, an inhibitor of negative muscle regulators, in healthy volunteers. Neuromuscul Disord. 2010;20(9–10):646. doi:10.1016/j.nmd.2010.07.160.

    Article  Google Scholar 

  57. McPherron AC, Lee SJ. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest. 2002;109(5):595–601. doi:10.1172/JCI13562.

    PubMed  CAS  Google Scholar 

  58. Allen DL, Cleary AS, Speaker KJ, Lindsay SF, Uyenishi J, Reed JM, et al. Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol Endocrinol Metab. 2008;294(5):E918–27. doi:10.1152/ajpendo.00798.2007.

    Article  PubMed  CAS  Google Scholar 

  59. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol. 2003;23(20):7230–42.

    Article  PubMed  CAS  Google Scholar 

  60. Lyons JA, Haring JS, Biga PR. Myostatin expression, lymphocyte population, and potential cytokine production correlate with predisposition to high-fat diet induced obesity in mice. PLoS One. 2010;5(9):e12928. doi:10.1371/journal.pone.0012928.

    Article  PubMed  Google Scholar 

  61. Feldman BJ, Streeper RS, Farese Jr RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006;103(42):15675–80. doi:10.1073/pnas.0607501103.

    Article  PubMed  CAS  Google Scholar 

  62. Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One. 2009;4(3):e4937. doi:10.1371/journal.pone.0004937.

    Article  PubMed  Google Scholar 

  63. Hittel DS, Berggren JR, Shearer J, Boyle K, Houmard JA. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes. 2009;58(1):30–8. doi:10.2337/db08-0943.

    Article  PubMed  CAS  Google Scholar 

  64. Pan H, Ping XC, Zhu HJ, Gong FY, Dong CX, Li NS, et al. Association of myostatin gene polymorphisms with obesity in Chinese north Han human subjects. Gene. 2012;494(2):237–41. doi:10.1016/j.gene.2011.10.045.

    Article  PubMed  CAS  Google Scholar 

  65. Milan G, Dalla Nora E, Pilon C, Pagano C, Granzotto M, Manco M, et al. Changes in muscle myostatin expression in obese subjects after weight loss. J Clin Endocrinol Metab. 2004;89(6):2724–7. doi:10.1210/jc.2003-032047.

    Article  PubMed  CAS  Google Scholar 

  66. Park JJ, Berggren JR, Hulver MW, Houmard JA, Hoffman EP. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Physiol Genomics. 2006;27(2):114–21. doi:10.1152/physiolgenomics.00045.2006.

    Article  PubMed  CAS  Google Scholar 

  67. Mendias CL, Bakhurin KI, Faulkner JA. Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc Natl Acad Sci U S A. 2008;105(1):388–93. doi:10.1073/pnas.0707069105.

    Article  PubMed  CAS  Google Scholar 

  68. Elkasrawy MN, Hamrick MW. Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010;10(1):56–63.

    PubMed  CAS  Google Scholar 

  69. • Hamrick MW. Myostatin (GDF-8) as a therapeutic target for the prevention of osteoporotic fractures. IBMS BoneKEy. 2010;7(1):8–17. doi:10.1138/20100423. Article which reviews the potential effects of myostatin signalling and its inhibition on bone.

    Article  Google Scholar 

  70. Hamrick MW, Samaddar T, Pennington C, McCormick J. Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise. J Bone Miner Res. 2006;21(3):477–83. doi:10.1359/JBMR.051203.

    Article  PubMed  CAS  Google Scholar 

  71. Bowser M, Herberg S, Arounleut P, Shi X, Fulzele S, Hill WD, et al. Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol. 2013;48(2):290–7. doi:10.1016/j.exger.2012.11.004.

    Article  PubMed  CAS  Google Scholar 

  72. Rothney MP, Martin FP, Xia Y, Beaumont M, Davis C, Ergun D, et al. Precision of GE Lunar iDXA for the measurement of total and regional body composition in nonobese adults. J Clin Densitom. 2012;15:399–404.

    Article  PubMed  Google Scholar 

  73. Lloyd TE. Novel therapeutic approaches for inclusion body myositis. Curr Opin Rheumatol. 2010;22(6):658–64. doi:10.1097/BOR.0b013e32833f0f4a.

    Article  PubMed  CAS  Google Scholar 

  74. Malik V, Rodino-Klapac LR, Mendell JR. Emerging drugs for Duchenne muscular dystrophy. Expert Opin Emerg Drugs. 2012;17(2):261–77. doi:10.1517/14728214.2012.691965.

    Article  PubMed  CAS  Google Scholar 

  75. Breitbart A, Auger-Messier M, Molkentin JD, Heineke J. Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting. Am J Physiol Heart Circ Physiol. 2011;300(6):H1973–82. doi:10.1152/ajpheart.00200.2011.

    Article  PubMed  CAS  Google Scholar 

  76. Anker MS, von Haehling S, Springer J, Banach M, Anker SD. Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology. Int J Cardiol. 2013;162(2):73–6. doi:10.1016/j.ijcard.2012.10.018.

    Article  PubMed  Google Scholar 

  77. Brass EP, Sietsema KE. Considerations in the development of drugs to treat sarcopenia. J Am Geriatr Soc. 2011;59(3):530–5. doi:10.1111/j.1532-5415.2010.03285.x.

    Article  PubMed  Google Scholar 

  78. Fischetto G, Bermon S. From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports? Sports Med. 2013. doi:10.1007/s40279-013-0075-4.

    PubMed  Google Scholar 

  79. van der Gronde T, de Hon O, Haisma HJ, Pieters T. Gene doping: an overview and current implications for athletes. Br J Sports Med. 2013;47(11):670–8. doi:10.1136/bjsports-2012-091288.

    Article  PubMed  Google Scholar 

  80. Anonymous. Overweight and Obesity. Center for Disease Control. 2013. http://www.cdc.gov/obesity/data/index.html. Accessed June 23, 2013.

  81. Holes-Lewis KA, Malcolm R, O'Neil PM. Pharmacotherapy of obesity: clinical treatments and considerations. Am J Med Sci. 2013;345(4):284–8. doi:10.1097/MAJ.0b013e31828abcfd.

    Article  PubMed  Google Scholar 

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B. Buehring is affiliated with an institution that has received a grant from Lilly. N. Binkley has received research grants from Amgen, Lilly, Merck, and Opko and is on an advisory board for Lilly and Merck.

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  1. Division of Geriatrics and Gerontology, University of Wisconsin Osteoporosis Clinical Research Program, UW Madison, 2870 University Ave, Suite 100, Madison, WI, 53705, USA

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  2. GRECC, William S Middleton Memorial VAH, Madison, WI, USA

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Buehring, B., Binkley, N. Myostatin – The Holy Grail for Muscle, Bone, and Fat?. Curr Osteoporos Rep 11, 407–414 (2013). https://doi.org/10.1007/s11914-013-0160-5

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