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Prevalence of metabolic syndrome in Japanese psoriasis patients

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  • Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome

    2017, Journal of the American Academy of Dermatology
    Citation Excerpt :

    In the main outcome meta-analysis, Middle Eastern patients with psoriasis exhibited a greater risk for MS compared with Europeans. These results are similar to those presented by Armstrong et al.7 The literature is consistent with our results, demonstrating that the Middle Eastern general population has an increased prevalence of MS (approximately 40%).35 European cohorts exhibit a prevalence near 25%.80

  • Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report

    2016, Cytokine
    Citation Excerpt :

    Psoriasis is not only limited to skin manifestations or Quality of Life (QOL) impairment for patients, but an association has also been proven between this condition and MS components, primarily in terms of abdominal obesity, hypertriglyceridemia, and low levels of High-Density-Lipoprotein-cholesterol (HDL-c) [31–35]. In addition to causing keratinocyte hyperproliferation and increased angiogenesis in these patients, Th1/Th17 profile alterations are known to share pathophysiological pathways derived from Th1-mediated chronic inflammation with CardioVascular Diseases (CVD) including obesity, diabetes, hyperlipidemia, atherosclerosis, and MS [34,36–43]. Our results support this close relationship.

  • Prevalence of metabolic syndrome as per the NCEP and IDF definitions vis-a-vis severity and duration of psoriasis in a semi-urban Maharashtrian population: A case control study

    2016, Diabetes and Metabolic Syndrome: Clinical Research and Reviews
    Citation Excerpt :

    Low HDL was the most common (though not the most significant) component of MS associated with our psoriatics (70%), significantly higher than controls (48%, P = 0.002). A higher prevalence of low HDL levels in psoriatics has been reported by Takahashi et al. [22], whereas Nisa and Quazi [9] demonstrated its higher prevalence in controls. We observed similar HDL levels in cases and controls, in contrast to Pietrzak et al. [23] who found significantly decreased high-density lipoprotein (HDL)-cholesterol concentration (P < 0.001) in cases.

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