PathologySialendoscopy of Salivary Glands Affected by Sjögren Syndrome: A Randomized Controlled Pilot Study
Section snippets
Study Population
Patients with SS were recruited from the Center for Special Care Dentistry (Amsterdam, The Netherlands) and through the Dutch Sjögren's Patients Federation. Written consent was obtained from each patient. Patients with primary and secondary SS 18 to 75 years of age were included. All patients fulfilled the American-European Consensus Group Classification Criteria for SS.14 Patients with acute sialadenitis, severe illness, or physical conditions making treatment under general anesthesia
Results
For this pilot study, data from 20 patients were used (Fig 1). The mean age was 56.6 years (range, 36 to 70 yr). All patients were women. Analysis of the data for normality showed that the XI, ESSPRI, CODS, MUC5B, and amylase concentration were normally distributed. UWS, SWS, MUC5B, and amylase output did not show a normal distribution (P < .001 by Shapiro-Wilk test).
The mean UWS and SWS were numerically higher at T2 and T3 compared with T0 in the intervention group (not meaningful). In the
Discussion
This trial investigated whether sialendoscopy of the major salivary glands could restore salivary function and thereby decrease dry mouth complaints of patients with SS. The results of the present pilot study suggest that sialendoscopy could have a positive effect on objective and subjective oral dryness measurements and patient-reported SS symptoms. No strong evidence was found that sialendoscopy could induce an increase in salivary flow, because this effect was not important.
Currently, there
Acknowledgments
The authors thank Marina Šumić and Tamana Alokozai for their assistance in the biochemical analyses and Karl Storz GmbH & Co for loaning the sialendoscopy sets and endoscopic video unit.
References (27)
- et al.
The overlap of Sjögren's syndrome with other systemic autoimmune diseases
Semin Arthritis Rheum
(2007) - et al.
Classification criteria for Sjogren's syndrome: A critical review
J Autoimmun
(2012) - et al.
Endoscopic treatment of salivary glands affected by autoimmune diseases
J Oral Maxillofac Surg
(2011) - et al.
Management of obstructive salivary disorders by sialendoscopy: A systematic review
Br J Oral Maxillofac Surg
(2015) - et al.
Sialendoscopic findings in patients with obstructive sialadenitis: Long-term experience
Br J Oral Maxillofac Surg
(2013) - et al.
Interventional sialoendoscopy for treatment of obstructive sialadenitis
J Oral Maxillofac Surg
(2014) Commentary on: Management of obstructive salivary disorders by sialendoscopy: A systematic review
Br J Oral Maxillofac Surg
(2015)Sialoendoscopy and salivary gland sparing surgery
Oral Maxillofac Surg Clin North Am
(2009)- et al.
Clinical assessment of oral dryness: Development of a scoring system related to salivary flow and mucosal wetness
Oral Surg Oral Med Oral Pathol Oral Radiol
(2012) - et al.
Endoscopic management of salivary gland obstructive diseases in patients with Sjögren's syndrome
J Craniomaxillofac Surg
(2015)
Sjögren's syndrome: A community-based study of prevalence and impact
Br J Rheumatol
Sjögren's syndrome
Lancet
How to assess treatment efficacy in Sjögrenʼs syndrome?
Curr Opin Rheumatol
Cited by (28)
World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for salivary hypofunction
2023, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyWorld Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for xerostomia
2023, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyDiagnostic and treatment effects of sialendoscopy for patients with swelling of the parotid gland when sialoliths are undetected with computed tomography
2018, Auris Nasus LarynxCitation Excerpt :In addition to microsialoliths and idiopathic stenosis, Sjögren’s syndrome and radioiodine therapy can cause obstructive gland disease [9,10]. A randomized pilot study of patients with Sjögren’s syndrome showed that sialendoscopic intervention had a positive effect on subjective xerostomia measurements and subjective symptoms [9]. However, it did not necessarily have a positive effect in one of our patients.
Complications of Sialendoscopy in Patients With Sjögren Syndrome
2017, Journal of Oral and Maxillofacial SurgeryCitation Excerpt :The study population was composed of patients who underwent sialendoscopy of submandibular and parotid glands from November 2014 through April 2015. These patients underwent sialendoscopy as part of a study in which the effect of sialendoscopy, with a sterile saline solution or a sterile saline solution and a steroid, of the major salivary glands on salivary flow, saliva composition, and mouth comfort in patients with SS was evaluated.6 Also, data from 6 patients who were included in a follow-up of this study were used.
Sialendoscopy-assisted treatment for chronic obstructive parotitis related to Sjogren syndrome
2017, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology