SpondylarthropathiesNo Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis—A Retrospective Cohort Study Using Routine Data
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The Secure Anonymized Information Linkage Databank
The Health Information Research Unit in Swansea University is funded by the Welsh Assembly Government to link electronically held routinely collected information to support health-related research. The Health Information Research Unit has set up the Secure Anonymized Information Linkage databank to bring together and anonymize the widest possible range of person-based data, which is performed using a split-file approach to overcome issues of confidentiality and disclosure in health-related data
Validation of GP Database Using a Rheumatology Dataset
Of 116 patients who have an AS code as identified by the rheumatology clinical dataset, 76% (89/116) were also recorded as having AS using GP records. Those not identified by the GP with AS (n = 27) were recorded by the GP as having back pain, knee pain, or other nonspecific symptoms. In addition, 12% (95% CI: 7% to 20%) (13/102) of patients identified within the GP as having AS were found in the rheumatology dataset but with a different diagnosis such as osteoarthritis (n = 5), disorder of
Discussion
This article uses a large dataset of linked longitudinal routine data to build on the evidence base regarding the risk of MI or stroke associated with AS and finds no evidence of a statistically significant increased rate of MI or stroke for those with a diagnosis of AS. In contrast, data from others indicate RA is associated with increased risk of MI and stroke, which accounts for the observed increased mortality in RA (3). Although both AS and RA are types of inflammatory arthritis, there are
Acknowledgments
This study makes use of anonymized data generated by the Secure Anonymized Information Linkage (SAIL) system, which is part of the national e-health records research infrastructure for Wales. We would like to acknowledge all the data providers who make anonymized data available for research.
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Recommendations for assessing the risk of cardiovascular disease and venous thromboembolism before the initiation of targeted therapies for chronic inflammatory rheumatic diseases
2024, Revue du Rhumatisme (Edition Francaise)Increased risk of stroke among patients with ankylosing spondylitis: A systematic review and meta-analysis
2023, Reumatologia ClinicaCitation Excerpt :Supplementary Table 2 provides the quality assessment of included studies, with most exhibiting good quality (NOS score ≥7). Eleven studies5,11,17–25 comprised 1.74 million subjects, reported around 26,000 cases of stroke. The pooled analyses of case–control and cohort studies showed that the overall risk of stroke is significantly higher (56%) in patients with ankylosing spondylitis (HR: 1.56, 95% CI: 1.33–1.79, P < 0.001; I2 = 94.8%) versus controls (Fig. 2).
Vascular involvement in axial spondyloarthropathies
2019, Joint Bone SpineAssociation of Acute Myocardial Infarction with ankylosing Spondylitis: A nationwide longitudinal cohort study
2018, Journal of Clinical NeuroscienceVascular involvement in axial spondyloarthropathies
2018, Revue du Rhumatisme (Edition Francaise)
This study was funded by the Medical Research Council (MRC) and National Institute of Social care and Health Research (NISCHR). All authors confirm there are no conflicts of interests regarding this work.