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22-04-2017 | Microbiome | Article

The Role of the Skin and Gut Microbiome in Psoriatic Disease

Journal:
Current Dermatology Reports

Authors: Di Yan, Naiem Issa, Ladan Afifi, Caleb Jeon, Hsin-Wen Chang, Wilson Liao

Publisher: Springer US

Abstract

Purpose of Review

To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls.

Recent Findings

Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of Streptococcus and a decreased level of Propionibacterium in psoriasis patients compared to controls. In the gut microbiome, the ratio of Firmicutes and Bacteroidetes was perturbed in psoriatic individuals compared to healthy controls. Actinobacteria was also relatively underrepresented in psoriasis patients relative to healthy individuals.

Summary

Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.

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