Non-pharmacologic treatment

Metformin use is associated with a significant reduction in the risk for total knee or hip replacement among people with type 2 diabetes, shows research published in CMAJ.

The Janus kinase inhibitor baricitinib has the potential to be “an important part of the treatment landscape” for juvenile arthritis, research suggests.

A diet and exercise program delivered in community settings may improve some clinical outcomes for people with knee osteoarthritis and overweight or obesity, suggest findings from the WE-CAN pragmatic randomized controlled trial.

Findings from a randomized controlled trial provide further evidence to support the beneficial impact of physical activity in people with spondyloarthritis.

Recurrent intra-articular corticosteroid injections are often inferior to other injectables, including placebo, for the long-term improvement of pain, function, and quality of life in people with osteoarthritis, meta-analysis data suggest.

People with knee osteoarthritis may experience modest improvements in physical function while following a 12-week self-guided online yoga program, but the benefits are not sustained when the exercise is stopped, researchers report.

Male sex and older age may put people with childhood-onset systemic lupus erythematosus and nephritis at increased risk for abnormal short-term kidney status, US researchers report.

Overweight and obesity during childhood may be associated with an increased risk for systemic lupus erythematosus and psoriatic arthritis that persists even if a healthy bodyweight is achieved during adulthood, researchers report.

Findings from three studies provide further support for the effectiveness and safety of COVID-19 vaccines in young people with rheumatic and musculoskeletal diseases.

Infliximab appears efficacious for patients with juvenile-onset spondyloarthritis who have failed to respond to conventional treatment, phase 3 study findings show.

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Intra-articular injection with botulinum toxin A results in clinically meaningful pain reduction for up to 3 months in people with base-of-thumb osteoarthritis, French study findings indicate.

Findings from a systematic review and meta-analysis indicate that viscosupplementation does not significantly improve pain and physical function in people with knee osteoarthritis, but increases the risk for serious adverse events.

The American College of Rheumatology and the American Association of Hip and Knee Surgeons have issued updated recommendations to guide perioperative use of antirheumatic medications among people with rheumatic diseases undergoing total hip or knee arthroplasty.

Telephone-delivered exercise and cognitive behavioral interventions improve fatigue severity and impact versus usual care in people with inflammatory rheumatic diseases, LIFT study data show.

Results from a post-hoc analysis suggest that increased dietary vitamin K intake is associated with greater improvement in symptoms among patients with knee osteoarthritis, warranting further examination in clinical trials.

Women with active rheumatoid arthritis who receive pregnancy counseling are as likely to breastfeed their children as women in the general population, indicate findings from the Preconceptional Counselling in Active Rheumatoid Arthritis study.