Skip to main content
Home
Latest news
Browse topics
Lupus Rheumatoid arthritis Spondyloarthropathies COVID-19 Browse all topics
In focus
Bimekizumab: Dual IL-17A/IL-17F inhibition in SpA Anifrolumab for the treatment of SLE JAK inhibitor safety: Weighing up the data and understanding the risks Rituximab and rheumatology practice in the COVID-19 era Safety snapshot: Upadacitinib in patients with PsA Repurposing rheumatology drugs for COVID-19 Telemedicine in rheumatology: COVID-19 and beyond Managing PsA in resource-limited settings
Conferences
ACR Convergence 2022 EULAR 2022 Congress
About us
Medicine Matters Rheumatology
EXTENDED SEARCH
Top

06-01-2016 | Osteoarthritis | Book Chapter | Article

1. Osteoarthritis: Definition, Etiology, and Natural History

Author: Elizabeth A. Arendt, MD

Publisher: Springer Berlin Heidelberg

Login to get access

Abstract

Osteoarthritis (OA) is one of the most common causes of disability in adults. The prevalence increases with age, with a surprising 13.9 % of the population over 25 years old being affected and 33.6 % of the population over 65 years old affected [1].
Literature
1.
Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58(1):26–35.CrossRefPubMedPubMedCentral
2.
Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494–502.CrossRefPubMedPubMedCentral
3.
Braun HJ, Gold GE. Diagnosis of osteoarthritis: imaging. Bone. 2012;51(2):278–88.CrossRefPubMed
4.
Wu CW, Morrell MR, Heinze E, et al. Validation of American College of Rheumatology classification criteria for knee osteoarthritis using arthroscopically defined cartilage damage scores. Semin Arthritis Rheum. 2005;35(3):197–201.CrossRefPubMed
5.
van Spil WE, DeGroot J, Lems WF, Oostveen JCM, Lafeber FPJG. Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria. Osteoarthritis Cartilage. 2010;18(5):605–12.CrossRefPubMed
6.
Lotz M, Martel-Pelletier J, Christiansen C, et al. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis. 2013;72(11):1756–63.CrossRefPubMedPubMedCentral
7.
Sheehy L, Culham E, McLean L, et al. Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis Study (MOST). Osteoarthritis Cartilage. 2015;23(9):1491–8.
8.
Kraus VB, Blanco FJ, Englund M, et al. OARSI clinical trials recommendations: soluble biomarker assessments in clinical trials in osteoarthritis. Osteoarthritis Cartilage. 2015;23(5):686–97.CrossRefPubMedPubMedCentral
9.
Felson DT. Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage. 2013;21(1):10–5.CrossRefPubMedPubMedCentral
10.
Bennell KL, Wrigley TV, Hunt MA, Lim BW, Hinman RS. Update on the role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am. 2013;39(1):145–76.CrossRefPubMed
11.
Toivanen AT, Heliovaara M, Impivaara O, et al. Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis–a population-based study with a follow-up of 22 years. Rheumatology (Oxford). 2010;49(2):308–14.CrossRef
12.
McWilliams DF, Leeb BF, Muthuri SG, Doherty M, Zhang W. Occupational risk factors for osteoarthritis of the knee: a meta-analysis. Osteoarthritis Cartilage. 2011;19(7):829–39.CrossRefPubMed
13.
Boyan BD, Tosi L, Coutts R, et al. Sex differences in osteoarthritis of the knee. J Am Acad Orthop Surg. 2012;20(10):668–9.PubMed
14.
Huffman KM, Kraus WE. Osteoarthritis and the metabolic syndrome: more evidence that the etiology of OA is different in men and women. Osteoarthritis Cartilage. 2012;20(7):603–4.CrossRefPubMedPubMedCentral
15.
Yucesoy B, Charles LE, Baker B, Burchfiel CM. Occupational and genetic risk factors for osteoarthritis: a review. Work. 2015;50(2):261–73.PubMedPubMedCentral
16.
Sowers MR, Karvonen-Gutierrez CA. The evolving role of obesity in knee osteoarthritis. Curr Opin Rheumatol. 2010;22(5):533–7.CrossRefPubMedPubMedCentral
17.
Yoshimura N, Muraki S, Oka H, et al. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage. 2012;20(11):1217–26.CrossRefPubMed
18.
Altman RD, Hochberg M, Murphy Jr WA, Wolfe F, Lequesne M. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage. 1995;3(Suppl A):3–70.PubMed
19.
Kornaat PR, Ceulemans RY, Kroon HM, et al. MRI assessment of knee osteoarthritis: Knee Osteoarthritis Scoring System (KOSS)–inter-observer and intra-observer reproducibility of a compartment-based scoring system. Skeletal Radiol. 2005;34(2):95–102.CrossRefPubMed
20.
Peterfy CG, Guermazi A, Zaim S, et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage. 2004;12(3):177–90.CrossRefPubMed
21.
Hunter DJ, Lo GH, Gale D, Grainger AJ, Guermazi A, Conaghan PG. The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score). Ann Rheum Dis. 2008;67(2):206–11.CrossRefPubMed
22.
Andriacchi TP, Favre J, Erhart-Hledik JC, Chu CR. A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease. Ann Biomed Eng. 2015;43(2):376–87.CrossRefPubMed
23.
Evangelou E, Valdes AM, Kerkhof HJ, et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis. 2011;70(2):349–55.CrossRefPubMed
24.
Kerkhof HJ, Bierma-Zeinstra SM, Arden NK, et al. Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors. Ann Rheum Dis. 2014;73(12):2116–21.CrossRefPubMed
25.
Lo GH, Driban JB, Kriska AM, et al. Habitual running any time in life is not detrimental and may be protective of symptomatic knee osteoarthritis. Data from the Osteoarthritis Initiative. American College of Rheumatology annual meeting, Boston, 2014.
26.
Sanghi D, Mishra A, Sharma AC, et al. Elucidation of dietary risk factors in osteoarthritis knee–a case–control study. J Am Coll Nutr. 2015;34(1):15–20.CrossRefPubMed
27.
Apold H, Meyer HE, Nordsletten L, Furnes O, Baste V, Flugsrud GB. Risk factors for knee replacement due to primary osteoarthritis, a population based, prospective cohort study of 315,495 individuals. BMC Musculoskelet Disord. 2014;15:217.CrossRefPubMedPubMedCentral
28.
Fanelli GC, Sousa PL, Edson CJ. Long-term followup of surgically treated knee dislocations: Stability restored, but arthritis is common. Clin Orthop Relat Res. 2014;472(9):2712–7.CrossRefPubMedPubMedCentral
29.
Logerstedt DS, Zeni Jr J, Snyder-Mackler L. Sex differences in patients with different stages of knee osteoarthritis. Arch Phys Med Rehabil. 2014;95(12):2376–81.CrossRefPubMedPubMedCentral
30.
Silverwood V, Blagojevic-Bucknall M, Jinks C, Jordan JL, Protheroe J, Jordan KP. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23(4):507–15.CrossRefPubMed
31.
Chundru R, Baum T, Nardo L, et al. Focal knee lesions in knee pairs of asymptomatic and symptomatic subjects with OA risk factors–data from the osteoarthritis initiative. Eur J Radiol. 2013;82(8):e367–73.CrossRefPubMedPubMedCentral
32.
Jungmann PM, Kraus MS, Alizai H, et al. Association of metabolic risk factors with cartilage degradation assessed by T2 relaxation time at the knee: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2013;65(12):1942–50.CrossRef
33.
Martin KR, Kuh D, Harris TB, Guralnik JM, Coggon D, Wills AK. Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort. BMC Musculoskelet Disord. 2013;14:219.CrossRefPubMedPubMedCentral
34.
Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73(9):1659–64.CrossRefPubMed
35.
Hansen P, English M, Willick SE. Does running cause osteoarthritis in the hip or knee? PM R. 2012;4(5 Suppl):S117–21.CrossRefPubMed
36.
Palmer KT. Occupational activities and osteoarthritis of the knee. Br Med Bull. 2012;102:147–70.CrossRefPubMedPubMedCentral
37.
Sridhar MS, Jarrett CD, Xerogeanes JW, Labib SA. Obesity and symptomatic osteoarthritis of the knee. J Bone Joint Surg Br. 2012;94(4):433–40.CrossRefPubMed
38.
Chaganti RK, Lane NE. Risk factors for incident osteoarthritis of the hip and knee. Curr Rev Musculoskelet Med. 2011;4(3):99–104.CrossRefPubMedPubMedCentral
39.
Hovis KK, Stehling C, Souza RB, et al. Physical activity is associated with magnetic resonance imaging-based knee cartilage T2 measurements in asymptomatic subjects with and those without osteoarthritis risk factors. Arthritis Rheum. 2011;63(8):2248–56.CrossRefPubMedPubMedCentral
40.
Jones G, Schultz MG, Dore D. Physical activity and osteoarthritis of the knee: can MRI scans shed more light on this issue? Phys Sportsmed. 2011;39(3):55–61.CrossRefPubMed
41.
Molloy MG, Molloy CB. Contact sport and osteoarthritis. Br J Sports Med. 2011;45(4):275–7.CrossRefPubMed
42.
Muthuri SG, McWilliams DF, Doherty M, Zhang W. History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies. Osteoarthritis Cartilage. 2011;19(11):1286–93.CrossRefPubMed
43.
Muthuri SG, Hui M, Doherty M, Zhang W. What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies. Arthritis Care Res (Hoboken). 2011;63(7):982–90.CrossRef
44.
Papavasiliou KA, Kenanidis EI, Potoupnis ME, Kapetanou A, Sayegh FE. Participation in athletic activities may be associated with later development of hip and knee osteoarthritis. Phys Sportsmed. 2011;39(4):51–9.CrossRefPubMed
45.
Segal NA, Glass NA. Is quadriceps muscle weakness a risk factor for incident or progressive knee osteoarthritis? Phys Sportsmed. 2011;39(4):44–50.CrossRefPubMed
46.
Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol. 2011;7(1):23–32.CrossRefPubMed
47.
Yusuf E, Bijsterbosch J, Slagboom PE, Rosendaal FR, Huizinga TW, Kloppenburg M. Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis. Osteoarthritis Cartilage. 2011;19(9):1117–22.CrossRefPubMed
48.
Klussmann A, Gebhardt H, Nubling M, et al. Individual and occupational risk factors for knee osteoarthritis: results of a case–control study in Germany. Arthritis Res Ther. 2010;12(3):R88.CrossRefPubMedPubMedCentral
49.
Stehling C, Lane NE, Nevitt MC, Lynch J, McCulloch CE, Link TM. Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative. Osteoarthritis Cartilage. 2010;18(6):776–86.CrossRefPubMedPubMedCentral
50.
Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010;18(1):24–33.CrossRefPubMed
Image Credits