medwireNews: People with osteoarthritis (OA) who undergo total knee replacement (TKR) may have a lower risk for major adverse cardiovascular events (MACE) and mortality than those who do not, researchers report.
These findings are based on an analysis of data from the National Health Insurance Research Database of Taiwan in 1999–2017.
Chih-Hao Chiu (Chang Gung Memorial Hospital, Taoyuan City, Taiwan) and co-authors found that the incidence of mortality or MACE was 47.67 per 10,000 person–months for the 10,314 people with knee OA who underwent TKR, compared with 59.94 per 10,000 person–months for the same number of propensity score-matched knee OA patients who did not undergo TKR. These rates translated into a significant 20.9% reduced risk for these outcomes in the TKR group after adjustment for factors including demographics and comorbidities.
These findings remained consistent when the outcomes of MACE and mortality were analyzed separately, and subgroup analyses demonstrated that TKR was associated with a “clear decrease” in the risk for these outcomes among both men and women, say Chiu et al in Osteoarthritis and Cartilage.
They also note that TKR was associated with significantly lower rates of nonsteroidal anti-inflammatory drug use at 1–2 years after surgery (46.2 vs 53.8% in the non-TKR group), albeit with “much higher” doses in the TKR group around the time of surgery.
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