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Osteoarthritis

Medications

18-03-2019 | Osteoarthritis | News

Findings question the use of acetaminophen for pain relief in OA patients

Results of a systematic review suggest that treatment with acetaminophen provides only minimal benefit compared with placebo for patients with osteoarthritis.

Tramadol linked to increased mortality risk in osteoarthritis patients

Mortality rates are significantly higher during the first year after a tramadol prescription than after prescription of common nonsteroidal anti-inflammatory drugs, but it is unclear whether the relationship is causal, say researchers.

12-03-2019 | Osteoarthritis | Highlight | News

Tramadol linked to increased mortality risk in osteoarthritis patients

Mortality rates are significantly higher during the first year after a tramadol prescription than after prescription of common nonsteroidal anti-inflammatory drugs, but it is unclear whether the relationship is causal, say researchers.

Ibuprofen may be a ‘reasonable option’ for analgesia after hip replacement

Patients who are treated with ibuprofen alone experience comparable pain control in the first day after hip replacement to those give acetaminophen plus ibuprofen, findings from the PANSAID trial suggest.

12-02-2019 | Osteoarthritis | Highlight | News

Ibuprofen may be a ‘reasonable option’ for analgesia after hip replacement

Patients who are treated with ibuprofen alone experience comparable pain control in the first day after hip replacement to those give acetaminophen plus ibuprofen, findings from the PANSAID trial suggest.

08-02-2019 | Osteoarthritis | News

Opioid use ‘alarmingly high’ among Swedish OA patients

Over a 1-year period, around one in four individuals with hip and/or knee osteoarthritis received opioids for pain management, compared with approximately one in 10 people without such a diagnosis, finds a Swedish population-based study.

Long-term impact unclear for knee OA medications

Findings from a systematic review and network meta-analysis published in JAMA indicate that it is not clear whether pharmacologic treatments offer long-term benefits for patients with knee osteoarthritis.

21-12-2018 | Osteoarthritis | Highlight | News

Long-term impact unclear for knee OA medications

Findings from a systematic review and network meta-analysis published in JAMA indicate that it is not clear whether pharmacologic treatments offer long-term benefits for patients with knee osteoarthritis.

19-12-2018 | Osteoarthritis | News

Targeting IL-1 ‘may not be effective’ for erosive hand OA

Findings from a randomized trial indicate that treatment with the interleukin-1α and -1β inhibitor lutikizumab does not improve pain or imaging outcomes among patients with erosive hand osteoarthritis.

29-11-2018 | Osteoarthritis | Article

Intra-articular treatment options for knee osteoarthritis

Jones IA et al. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0123-4

18-10-2018 | Osteoarthritis | News

No pain relief with etanercept for hand OA

Treatment with the tumor necrosis factor inhibitor etanercept does not reduce pain at 24 weeks, compared with placebo, in patients with erosive hand osteoarthritis, preliminary trial data show.

Calcium crystal deposition diseases: Beyond gout

In this review, the main clinical manifestations of calcium pyrophosphate dihydrate and basic calcium phosphate crystal deposition are discussed, along with the biological effects of these crystals, current therapeutic approaches and future directions in therapy [read more].
McCarthy GM, Dunne A. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0078-5

19-09-2018 | Osteoarthritis | News

Extended-release triamcinolone acetonide viable for osteoarthritis patients with type 2 diabetes

Triamcinolone acetonide extended-release may be a good option for the treatment of knee osteoarthritis in patients with comorbid type 2 diabetes, suggest phase II study findings.

18-09-2018 | Osteoarthritis | Review | Article

Fixed-dose combination amlodipine/celecoxib (Consensi) for hypertension and osteoarthritis

Smith SM, Cooper-DeHoff RM. Am J Med 2018. doi: 10.1016/j.amjmed.2018.08.027

06-09-2018 | Calcium crystal deposition disease | Review | Article

Calcium crystal deposition diseases: Beyond gout

McCarthy GM, Dunne A. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0078-5

06-09-2018 | Osteoarthritis | Article

Triamcinolone acetonide extended-release in patients with osteoarthritis and type 2 diabetes: A randomized, phase 2 study

Russell SJ et al. Rheumatology (Oxford) 2018: key265. doi: 10.1093/rheumatology/key265

Updated EULAR guidance for managing hand OA published

EULAR has issued updated recommendations for the management of hand osteoarthritis based on current evidence and expert opinion.

30-08-2018 | Osteoarthritis | Highlight | News

Updated EULAR guidance for managing hand OA published

EULAR has issued updated recommendations for the management of hand osteoarthritis based on current evidence and expert opinion.

Oral OA therapy not linked to knee replacement risk

Exposure to oral osteoarthritis therapies is unlikely to be a risk factor for requiring knee replacement, suggests an analysis of the Osteoarthritis Initiative database.

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