Skip to main content
main-content
Top

08-06-2018 | Pain | Review | Article

Cannabinoids for the treatment of rheumatic diseases — where do we stand?

Journal:
Nature Reviews Rheumatology

Authors: Daphna Katz-Talmor, Itay Katz, Bat-Sheva Porat-Katz, Yehuda Shoenfeld

Publisher: Nature Publishing Group UK

Abstract

As medical use of cannabis is increasingly legalized worldwide, a better understanding of the medical and hazardous effects of this drug is imperative. The pain associated with rheumatic diseases is considered a prevalent indication for medicinal cannabis in various countries. Thus far, preliminary clinical trials have explored the effects of cannabis on rheumatoid arthritis, osteoarthritis and fibromyalgia; preliminary evidence has also found an association between the cannabinoid system and other rheumatic conditions, including systemic sclerosis and juvenile idiopathic arthritis. The potential medicinal effects of cannabis could be attributable to its influence on the immune system, as it exerts an immunomodulatory effect on various immune cells, including T cells, B cells and macrophages. However, the available evidence is not yet sufficient to support the recommendation of cannabinoid treatment for rheumatic diseases.

Please log in to get access to this content

Related topics