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23-07-2018 | Pain disorders | Review | Article

Current Concepts and Future Directions of Minimally Invasive Treatment for Knee Pain

Journal: Current Rheumatology Reports

Authors: Daryl T. Goldman, Rachel Piechowiak, Daniel Nissman, Sandeep Bagla, Ari Isaacson

Publisher: Springer US

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Abstract

Purpose of Review

The purpose of this paper is to review the percutaneous interventions available for the treatment of osteoarthrosis of the knee that address pain and prolong the time to arthroplasty.

Recent Findings

Corticosteroid injection and viscosupplementation have been the most studied, but there is still no consensus about their value. Thermal nerve ablation, including both radiofrequency ablation and cryoneurolysis, is a promising new modality of therapy that may increase in clinical use given current data showing favorable outcomes. Of the future therapies that are currently under investigation, synovial embolization via the geniculate arteries represents an exciting new approach that may soon be available clinically.

Summary

There are various percutaneous interventions available for the treatment of osteoarthrosis of the knee that address pain and prolong the time to arthroplasty.
Literature
1.
Bhatia A, Peng P, Cohen SP. Radiofrequency procedures to relieve chronic knee pain: an evidence-based narrative review. Reg Anesth Pain Med. 2016;41(4):501–10.PubMedCrossRef
2.
Lluch Girbes E, Nijs J, Torres-Cueco R, Lopez CC. Pain treatment for patients with osteoarthritis and central sensitization. Phys Ther. 2013;93(6):842–51.PubMedCrossRef
3.
Akeson WH, Garfin S, Amiel D, Woo SL. Para-articular connective tissue in osteoarthritis. Semin Arthritis Rheum. 1989;18(4 Suppl 2):41–50.PubMedCrossRef
4.
Gronblad M, Liesi P, Korkala O, Karaharju E, Polak J. Innervation of human bone periosteum by peptidergic nerves. Anat Rec. 1984;209(3):297–9.PubMedCrossRef
5.
Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol. 1997;24(2):365–71.PubMed
6.
Schianchi PM, Sluijter ME, Balogh SE. The treatment of joint pain with intra-articular pulsed radiofrequency. Anesth Pain Med. 2013;3(2):250–5.PubMedPubMedCentralCrossRef
7.
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42.PubMedCrossRef
8.
Delbarre A, Amor B, Bardoulat I, Tetafort A, Pelletier-Fleury N. Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis - a Cox model analysis. PLoS One. 2017;12(11):e0187227.PubMedPubMedCentralCrossRef
9.
Turajane T, Chaveewanakorn U, Fongsarun W, Aojanepong J, Papadopoulos KI. Avoidance of total knee arthroplasty in early osteoarthritis of the knee with intra-articular implantation of autologous activated peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial with differential effects of growth factor addition. Stem Cells Int. 2017;2017:8925132.PubMedPubMedCentralCrossRef
10.
Wang SX, Abramson SB, Attur M, Karsdal MA, Preston RA, Lozada CJ, et al. Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study. Osteoarthr Cartil. 2017;25(12):1952–61.PubMedCrossRef
11.
Dai WL, Zhou AG, Zhang H, Zhang J. Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Arthroscopy. 2017;33(3):659–670.e651.PubMedCrossRef
12.
Richards MM, Maxwell JS, Weng L, Angelos MG, Golzarian J. Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine. Phys Sportsmed. 2016;44(2):101–8.PubMedPubMedCentralCrossRef
13.
Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD. Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review. Arthroscopy. 2016;32(3):495–505.PubMedCrossRef
14.
Campbell KA, Erickson BJ, Saltzman BM, et al. Is local viscosupplementation injection clinically superior to other therapies in the treatment of osteoarthritis of the knee: a systematic review of overlapping meta-analyses. Arthroscopy. 2015;31(10):2036–2045.e2014.PubMedCrossRef
15.
Lai LP, Stitik TP, Foye PM, Georgy JS, Patibanda V, Chen B. Use of platelet-rich plasma in intra-articular knee injections for osteoarthritis: a systematic review. PM R. 2015;7(6):637–48.PubMedCrossRef
16.
Khoshbin A, Leroux T, Wasserstein D, Marks P, Theodoropoulos J, Ogilvie-Harris D, et al. The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. Arthroscopy. 2013;29(12):2037–48.PubMedCrossRef
17.
Adriani E, Moio M, Di Paola B, et al. Percutaneous fat transfer to treat knee osteoarthritis symptoms: preliminary results. Joints. 2017;5(2):89–92.PubMedPubMedCentralCrossRef
18.
Rahimzadeh P, Imani F, Faiz SH, Alebouyeh MR, Azad-Ehyaei D, Bahari L, et al. Adding intra-articular growth hormone to platelet rich plasma under ultrasound guidance in knee osteoarthritis: a comparative double-blind clinical trial. Anesth Pain Med. 2016;6(6):e41719.PubMedPubMedCentralCrossRef
19.
MILLER JH, WHITE J, NORTON TH. The value of intra-articular injections in osteoarthritis of the knee. J Bone Joint Surg Br. 1958;40-B(4):636–43.PubMedCrossRef
20.
Hepper CT, Halvorson JJ, Duncan ST, Gregory AJ, Dunn WR, Spindler KP. The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies. J Am Acad Orthop Surg. 2009;17(10):638–46.PubMedCrossRef
21.
Gaffney K, Ledingham J, Perry JD. Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response. Ann Rheum Dis. 1995;54(5):379–81.PubMedPubMedCentralCrossRef
22.
Dieppe PA, Sathapatayavongs B, Jones HE, Bacon PA, Ring EF. Intra-articular steroids in osteoarthritis. Rheumatol Rehabil. 1980;19(4):212–7.PubMedCrossRef
23.
Friedman DM, Moore ME. The efficacy of intraarticular steroids in osteoarthritis: a double-blind study. J Rheumatol. 1980;7(6):850–6.PubMed
24.
Jones A, Doherty M. Intra-articular corticosteroids are effective in osteoarthritis but there are no clinical predictors of response. Ann Rheum Dis. 1996;55(11):829–32.PubMedPubMedCentralCrossRef
25.
Ravaud P, Moulinier L, Giraudeau B, Ayral X, Guerin C, Noel E, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial. Arthritis Rheum. 1999;42(3):475–82.PubMedCrossRef
26.
Arroll B, Goodyear-Smith F. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ. 2004;328(7444):869.PubMedPubMedCentralCrossRef
27.
Hirsch G, Kitas G, Klocke R. Intra-articular corticosteroid injection in osteoarthritis of the knee and hip: factors predicting pain relief--a systematic review. Semin Arthritis Rheum. 2013;42(5):451–73.PubMedCrossRef
28.
Felson DT. Intra-articular corticosteroids and knee osteoarthritis: interpreting different meta-analyses. JAMA. 2016;316(24):2607–8.PubMedCrossRef
29.
Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2003;48(2):370–7.PubMedCrossRef
30.
Kumar A, Dhir V, Sharma S, Sharma A, Singh S. Efficacy of methylprednisolone acetate versus triamcinolone acetonide intra-articular knee injection in patients with chronic inflammatory arthritis: a 24-week randomized controlled trial. Clin Ther. 2017;39(1):150–8.PubMedCrossRef
31.
Jüni P, Hari R, Rutjes AW, et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015;10:CD005328.
32.
Nguyen C, Rannou F. The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review. Expert Opin Drug Saf. 2017;16(8):897–902.PubMedCrossRef
33.
Balazs EA. Viscosupplementation for treatment of osteoarthritis: from initial discovery to current status and results. Surg Technol Int. 2004;12:278–89.PubMed
34.
Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther. 2003;5(2):54–67.PubMedPubMedCentralCrossRef
35.
Bali JP, Cousse H, Neuzil E. Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system. Semin Arthritis Rheum. 2001;31(1):58–68.PubMedCrossRef
36.
Evaniew N, Simunovic N, Karlsson J. Cochrane in CORR®: viscosupplementation for the treatment of osteoarthritis of the knee. Clin Orthop Relat Res. 2014;472(7):2028–34.PubMedCrossRef
37.
Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;2:CD005321.
38.
Altman RD, Bedi A, Karlsson J, Sancheti P, Schemitsch E. Product differences in intra-articular hyaluronic acids for osteoarthritis of the knee. Am J Sports Med. 2016;44(8):2158–65.PubMedCrossRef
39.
Cheng OT, Souzdalnitski D, Vrooman B, Cheng J. Evidence-based knee injections for the management of arthritis. Pain Med. 2012;13(6):740–53.PubMedPubMedCentralCrossRef
40.
Trojian TH, Concoff AL, Joy SM, Hatzenbuehler JR, Saulsberry WJ, Coleman CI. AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes. Clin J Sport Med. 2016;26(1):1–11.PubMedCrossRef
41.
Poddar SK, Widstrom L. Nonoperative options for management of articular cartilage disease. Clin Sports Med. 2017;36(3):447–56.PubMedCrossRef
42.
Henrotin Y, Raman R, Richette P, Bard H, Jerosch J, Conrozier T, et al. Consensus statement on viscosupplementation with hyaluronic acid for the management of osteoarthritis. Semin Arthritis Rheum. 2015;45(2):140–9.PubMedCrossRef
43.
Rutjes AW, Jüni P, da Costa BR, Trelle S, Nüesch E, Reichenbach S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med. 2012;157(3):180–91.PubMedCrossRef
44.
Miller LE, Block JE. US-approved intra-articular hyaluronic acid injections are safe and effective in patients with knee osteoarthritis: systematic review and meta-analysis of randomized, saline-controlled trials. Clin Med Insights Arthritis Musculoskelet Disord. 2013;6:57–63.PubMedPubMedCentralCrossRef
45.
Jevsevar DS. Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013;21(9):571–6.PubMed
46.
Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012;64(4):465–74.CrossRef
47.
Peterson C, Hodler J. Adverse events from diagnostic and therapeutic joint injections: a literature review. Skelet Radiol. 2011;40(1):5–12.CrossRef
48.
Hunter DJ. Viscosupplementation for osteoarthritis of the knee. N Engl J Med. 2015;372(11):1040–7.PubMedCrossRef
49.
Hammesfahr JF, Knopf AB, Stitik T. Safety of intra-articular hyaluronates for pain associated with osteoarthritis of the knee. Am J Orthop (Belle Mead NJ). 2003;32(6):277–83.
50.
Kroesen S, Schmid W, Theiler R. Induction of an acute attack of calcium pyrophosphate dihydrate arthritis by intra-articular injection of hylan G-F 20 (Synvisc). Clin Rheumatol. 2000;19(2):147–9.PubMedCrossRef
51.
• Shewale AR, Barnes CL, Fischbach LA, Ounpraseuth ST, Painter JT, Martin BC. Comparative effectiveness of intra-articular hyaluronic acid and corticosteroid injections on the time to surgical knee procedures. J Arthroplast. 2017;32(12):3591–3597.e3524. This study provides a thorough comparison of the effectiveness of intra-articular hyaluronic acid and corticosteroid injections on the treatment of pain secondary to OA and the time to surgery.CrossRef
52.
Kabiri A, Esfandiari E, Esmaeili A, Hashemibeni B, Pourazar A, Mardani M. Platelet-rich plasma application in chondrogenesis. Adv Biomed Res. 2014;3:138.PubMedPubMedCentralCrossRef
53.
Kabiri A, Esfandiari E, Esmaeili A, Hashemibeni B, Pourazar A, Mardani M. Platelet-rich plasma application in chondrogenesis. Adv Biomed Res. 2014;3:138.PubMedPubMedCentralCrossRef
54.
Sundman EA, Cole BJ, Karas V, et al. The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis. Am J Sports Med. 2014;42(1):35–41.PubMedCrossRef
55.
van Buul GM, Koevoet WL, Kops N, et al. Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. Am J Sports Med. 2011;39(11):2362–70.PubMedCrossRef
56.
Smith PA. Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. Am J Sports Med. 2016;44(4):884–91.PubMedCrossRef
57.
Huang PH, Wang CJ, Chou WY, Wang JW, Ko JY. Short-term clinical results of intra-articular PRP injections for early osteoarthritis of the knee. Int J Surg. 2017;42:117–22.PubMedCrossRef
58.
• Joshi Jubert N, Rodríguez L, Reverté-Vinaixa MM, Navarro A. Platelet-rich plasma injections for advanced knee osteoarthritis: a prospective, randomized, double-blinded clinical trial. Orthop J Sports Med. 2017;5(2):2325967116689386. This prospective, randomized, double-blinded clinical trial provides a thorough comparrison of the efficacy of PRP, corticosteroid, and HA injections.PubMedPubMedCentralCrossRef
59.
Wong KL, Lee KB, Tai BC, Law P, Lee EH, Hui JH. Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years’ follow-up. Arthroscopy. 2013;29(12):2020–8.PubMedCrossRef
60.
Varma HS, Dadarya B, Vidyarthi A. The new avenues in the management of osteo-arthritis of knee--stem cells. J Indian Med Assoc. 2010;108(9):583–5.PubMed
61.
Rodriguez-Merchan EC. Intra-articular injections of mesenchymal stem cells for knee osteoarthritis. Am J Orthopedics (Belle Mead, NJ). 2014;43(12):E282–91.
62.
Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL, Moen MH. Stem cell injections in knee osteoarthritis: a systematic review of the literature. Br J Sports Med. 2017;51(15):1125–33.PubMedCrossRef
63.
Koh YG, Jo SB, Kwon OR, et al. Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy. 2013;29(4):748–55.PubMedCrossRef
64.
Koh YG, Choi YJ. Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. Knee. 2012;19(6):902–7.PubMedCrossRef
65.
Koh YG, Kwon OR, Kim YS, Choi YJ. Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Arthroscopy. 2014;30(11):1453–60.PubMedCrossRef
66.
Saw KY, Anz A, Siew-Yoke Jee C, et al. Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial. Arthroscopy. 2013;29(4):684–94.PubMedCrossRef
67.
Vega A, Martin-Ferrero MA, Del Canto F, et al. Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial. Transplantation. 2015;99(8):1681–90.PubMedCrossRef
68.
Wei CC, Lin AB, Hung SC. Mesenchymal stem cells in regenerative medicine for musculoskeletal diseases: bench, bedside, and industry. Cell Transplant. 2014;23(4–5):505–12.PubMedCrossRef
69.
Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98(5):1076–84.PubMedCrossRef
70.
Khenioui H, Houvenagel E, Catanzariti JF, Guyot MA, Agnani O, Donze C. Usefulness of intra-articular botulinum toxin injections. A systematic review. Joint Bone Spine. 2016;83(2):149–54.PubMedCrossRef
71.
Boon AJ, Smith J, Dahm DL, et al. Efficacy of intra-articular botulinum toxin type A in painful knee osteoarthritis: a pilot study. PM R 2010;2(4):268–276.
72.
Singh JA, Mahowald ML, Noorbaloochi S. Intraarticular botulinum toxin A for refractory painful total knee arthroplasty: a randomized controlled trial. J Rheumatol. 2010;37(11):2377–86.PubMedPubMedCentralCrossRef
73.
Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002;39(1–2):237–46.PubMed
74.
Wang J. Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: an open-label randomized controlled trial. J Int Med Res 2017:300060517723182.
75.
Zarringam D, Bekkers JEJ, Saris DBF. Long-term effect of injection treatment for osteoarthritis in the knee by orthokin autologous conditioned serum. Cartilage 2017:1947603517743001.
76.
Auw Yang KG, Raijmakers NJ, van Arkel ER, et al. Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial. Osteoarthr Cartil 2008;16(4):498–505.
77.
Baltzer AW, Moser C, Jansen SA, Krauspe R. Autologous conditioned serum (orthokine) is an effective treatment for knee osteoarthritis. Osteoarthr Cartil. 2009;17(2):152–60.PubMedCrossRef
78.
Chevalier X, Goupille P, Beaulieu AD, et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2009;61(3):344–52.PubMedCrossRef
79.
Lopes de Jesus CC, Dos Santos FC, de Jesus LMOB, Monteiro I, Sant'Ana MSSC, Trevisani VFM. Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: a randomized, double-blinded, placebo-controlled study. PLoS One. 2017;12(7):e0179185.PubMedPubMedCentralCrossRef
80.
Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):485–92.PubMedCrossRef
81.
Iannaccone F, Dixon S, Kaufman AA. Review of long-term pain relief after genicular nerve radiofrequency ablation in chronic knee osteoarthritis. Pain physician. 2017;20(3):E437–e444.PubMed
82.
Hirasawa Y, Okajima S, Ohta M, Tokioka T. Nerve distribution to the human knee joint: anatomical and immunohistochemical study. Int Orthop. 2000;24(1):1–4.PubMedPubMedCentralCrossRef
83.
Kim SY, Le PU, Kosharskyy B, Kaye AD, Shaparin N, Downie SA. Is Genicular nerve radiofrequency ablation safe? A literature review and anatomical study. Pain Physician. 2016;19(5):E697–705.PubMed
84.
Orduña Valls JM, Vallejo R, López Pais P, et al. Anatomic and ultrasonographic evaluation of the knee sensory innervation: a cadaveric study to determine anatomic targets in the treatment of chronic knee pain. Reg Anesth Pain Med. 2017;42(1):90–8.PubMedCrossRef
85.
Franco CD, Buvanendran A, Petersohn JD, Menzies RD, Menzies LP. Innervation of the anterior capsule of the human knee: implications for radiofrequency ablation. Reg Anesth Pain Med. 2015;40(4):363–8.PubMedCrossRef
86.
Choi WJ, Hwang SJ, Song JG, et al. Radiofrequency treatment relieves chronic knee osteoarthritis pain: a double-blind randomized controlled trial. Pain. 2011;152(3):481–7.PubMedCrossRef
87.
McCormick ZL, Korn M, Reddy R, et al. Cooled radiofrequency ablation of the genicular nerves for chronic pain due to knee osteoarthritis: six-month outcomes. Pain Med. 2017;18(9):1631–41.PubMedCrossRef
88.
Gupta A, Huettner DP, Dukewich M. Comparative effectiveness review of cooled versus pulsed radiofrequency ablation for the treatment of knee osteoarthritis: a systematic review. Pain Physician. 2017;20(3):155–71.PubMed
89.
Cahana A, Van Zundert J, Macrea L, van Kleef M, Sluijter M. Pulsed radiofrequency: current clinical and biological literature available. Pain Med. 2006;7(5):411–23.PubMedCrossRef
90.
Cosman ER, Dolensky JR, Hoffman RA. Factors that affect radiofrequency heat lesion size. Pain Med. 2014;15(12):2020–36.PubMedCrossRef
91.
Rojhani S, Qureshi Z, Chhatre A. Water-cooled radiofrequency provides pain relief, decreases disability, and improves quality of life in chronic knee osteoarthritis. Am J Phys Med Rehabil. 2017;96(1):e5–8.PubMedCrossRef
92.
Davis T, Loudermilk E, DePalma M, et al. Prospective, multicenter, randomized, crossover clinical trial comparing the safety and effectiveness of cooled radiofrequency ablation with corticosteroid injection in the management of knee pain from osteoarthritis. Reg Anesth Pain Med. 2018;43(1):84–91.PubMedCrossRef
93.
Lazaro LE, Cross MB, Lorich DG. Vascular anatomy of the patella: implications for total knee arthroplasty surgical approaches. Knee. 2014;21(3):655–60.PubMedCrossRef
94.
Bittman RW, Peters GL, Newsome JM, et al. Percutaneous image-guided cryoneurolysis. AJR Am J Roentgenol. 2018;210(2):454–65.PubMedCrossRef
95.
Radnovich R, Scott D, Patel AT, et al. Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial. Osteoarthr Cartil. 2017;25(8):1247–56.PubMedCrossRef
96.
Hsu M, Stevenson FF. Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. Muscle Nerve. 2015;51(2):268–75.PubMedCrossRef
97.
Guillot X, Tordi N, Prati C, Verhoeven F, Pazart L, Wendling D. Cryotherapy decreases synovial Doppler activity and pain in knee arthritis: a randomized-controlled trial. Joint Bone Spine. 2017;84(4):477–83.PubMedCrossRef
98.
Guillot X, Martin H, Seguin-Py S, et al. Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6/IL-17 pathway but independently of TNFα. PLoS One. 2017;12(7):e0178668.PubMedPubMedCentralCrossRef
99.
•• Okuno Y, Korchi AM, Shinjo T, Kato S, Kaneko T. Midterm clinical outcomes and MR imaging changes after transcatheter arterial embolization as a treatment for mild to moderate radiographic knee osteoarthritis resistant to conservative treatment. J Vasc Interv Radiol : JVIR. 2017;28(7):995–1002. This study serves as a thorough description of GAE and provides mid-term experience (up to 4 years) with GAE in patients with moderate to severe pain related to OA.PubMedCrossRef
100.
Weidner ZD, Hamilton WG, Smirniotopoulos J, Bagla S. Recurrent hemarthrosis following knee arthroplasty treated with arterial embolization. J Arthroplast. 2015;30(11):2004–7.CrossRef
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