medwireNews: Analysis of data from the EQUATOR trial indicates that treatment with the selective Janus kinase 1 inhibitor filgotinib is associated with a significant improvement in health-related quality of life (HRQoL) among patients with active psoriatic arthritis (PsA).
These findings are “in line with the primary clinical outcomes of the study,” say the researchers. The main findings of the phase II trial, reported previously by medwireNews, showed that patients treated with filgotinib experienced significant improvements in multiple disease domains compared with those given placebo.
In the QoL analysis, reported in Rheumatology, Ana-Maria Orbai (Johns Hopkins University School of Medicine, Baltimore, Maryland, USA) and team found that average improvements in Psoriatic Arthritis Impact of Disease (PsAID)9 score – a patient-reported outcome developed specifically for PsA – from baseline to week 4 and week 16 were significantly greater among patients treated with filgotinib versus placebo (1.9 vs 1.5 and 2.3 vs 0.8 points, respectively).
Moreover, a significantly higher proportion of patients in the filgotinib compared with the placebo arm achieved the minimal clinically important improvement of at least 3 points in the PsAID9 score, both at week 4 (26.2 vs 8.6%) and at week 16 (42.6 vs 17.2%).
Similar improvements were observed when the 36-item short-form health survey scores were used to measure HRQoL.
Noting that “EQUATOR is the first randomized controlled trial to evaluate PsAID9,” the team concludes that these data support use of the tool in future PsA studies.
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