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12-01-2016 | Psoriatic arthritis | Book Chapter | Article

7. Immunopathology of the Psoriatic Arthritis Musculoskeletal Lesions

Author: MD, PhD Kurt de Vlam

Publisher: Springer International Publishing


Psoriatic arthritis is a complex inflammatory joint disease associated with psoriasis. The immunopathology of the skin and joint involvement resembles each other in some aspects but not all of them. Joint involvement is characterized by hypervascularity, cellular hypertrophy and inflammatory cellular infiltrate. Lymphocytes and dendritic cells play an important role in the pathogenesis of psoriasis and psoriatic arthritis; Their role in the early and late phase of the disease has still to be elucidated. Among the lymphocytes there is an important role for the Th17 cells linking the innate and adaptive immune systems. Future therapies are focusing on these effector cells and their products. Pre-osteoclasts and mature osteoclasts are other important players in the disease process, especially in psoriatic arthritis.
The immunopathology of psoriatic arthritis is just at the early beginning of unravelling its secrets.

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