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12-01-2016 | Psoriatic arthritis | Book Chapter | Article

13. Mechanisms of Bone Remodelling in Psoriatic Arthritis

Authors: MD, PhD Nigil Haroon, MD, MPH Christopher Ritchlin

Publisher: Springer International Publishing

Abstract

Psoriatic arthritis (PsA) is characterized by chronic inflammatory arthritis associated with skin and/or nail changes of psoriasis. PsA manifests in the peripheral joints with both bone destruction and new bone formation while in the spine there is aberrant bone formation and vertebral fusion. The pathogenic basis for the co-existence of bone loss and paradoxical bone formation has not been explained. Several exciting discoveries in this area has improved our understanding of bone homeostatic abnormalities in PsA and these will be explored in this chapter.

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