PsA treatment success can be predicted at 3 months
medwireNews: Disease activity after 3 months of treatment can predict the long-term success of tumor necrosis factor (TNF) inhibitor therapy in patients with psoriatic arthritis (PsA), researchers report.
“This substantiates the choice of the 3-month assessment as essential for treatment adaptations” to optimize long-term outcomes, say Daniel Aletaha (Vienna Medical University, Austria) and study co-authors.
The team analyzed data from 216 golimumab-treated patients who participated in the GO-REVEAL trial, and found that disease activity index for PsA (DAPSA) scores at 3 months were “very strong predictors” of achieving low disease activity (LDA) after 6 months and 1 year, correctly identifying patients with LDA on a corresponding 92% and 88% of occasions.
Similarly, patients with an early treatment response – defined as an 85% or greater improvement in the DAPSA score at 3 months – had an 84% likelihood of achieving LDA at 6 months, and an 82% chance of reaching this endpoint at 1 year. These results remained consistent in a validation cohort of infliximab-treated patients from the IMPACT 2 trial.
These findings indicate “that the potential of a new therapy to suppress disease activity sufficiently at 6 months or 1 year can be predicted well at the 3-month time point, depending on whether or not patients prove to be responding at this early assessment,” concludes the team in Rheumatology.
medwireNews is an independent medical news service provided by Springer Healthcare. © 2018 Springer Healthcare part of the Springer Nature group