Top

22-02-2018 | Rheumatoid arthritis | Article

Cost of Depression in Japanese Patients with Rheumatoid Arthritis: Evidence from Administrative Data

Journal: Rheumatology and Therapy

Authors: Florent Guelfucci, Yuko Kaneko, Jörg Mahlich, Rosarin Sruamsiri

Publisher: Springer Healthcare

Abstract

Introduction

To determine the cost of depression comorbidity among Japanese adults with rheumatoid arthritis (RA).

Methods

A retrospective database study of 8968 patients diagnosed with RA between 2010 and 2015 and treated with any RA medication was conducted. Health care utilization characteristics were compared between patients with and without a comorbidity of depression. Propensity score matching was applied to ensure a balanced comparison between the two cohorts.

Results

The prevalence of a depression comorbidity was found for 5% of the total RA patients. This comorbidity was associated with 62% (56%) higher total outpatient visits and 66% (163%) higher rate of emergency room visits after 6 (12) months.

Conclusions

Burden of depression among RA patients in Japan is relatively high and awareness for depression as a comorbidity of RA needs to be reinforced.

Funding

Janssen Pharmaceutical KK.

Dickens C, McGowan L, Clark-Carter D, Creed F. Depression in rheumatoid arthritis: a systematic review of the literature with meta-analysis. Psychosom Med. 2002;64(1):52–60.CrossRefPubMed

Löwe B, Willand L, Eich W, Zipfel S, Ho AD, Herzog W, et al. Psychiatric comorbidity and work disability in patients with inflammatory rheumatic diseases. Psychosom Med. 2004;66(3):395–402.PubMed

Isik A, Koca SS, Ozturk A, Mermi O. Anxiety and depression in patients with rheumatoid arthritis. Clin Rheumatol. 2007;26(6):872–8.CrossRefPubMed

Bruce TO. Comorbid depression in rheumatoid arthritis: pathophysiology and clinical implications. Curr Psychiatry Rep. 2008;10(3):258–64.CrossRefPubMed

Matcham F, Rayner L, Steer S, Hotopf M. The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology (Oxford). 2013;52(12):2136–48.CrossRef

Li X, Gignac MA, Anis AH. The indirect costs of arthritis resulting from unemployment, reduced performance, and occupational changes while at work. Med Care. 2006;44(4):304–10.CrossRefPubMed

Margaretten M, Julian L, Katz P, Yelin E. Depression in patients with rheumatoid arthritis: description, causes and mechanisms. Int J Clin Rheumtol. 2011;6(6):617–23.CrossRefPubMedPubMedCentral

Sruamsiri R, Mahlich J, Tanaka E, Yamanaka H. Productivity loss of Japanese patients with rheumatoid arthritis—a cross-sectional survey. Mod Rheumatol. 2017. https://doi.org/10.1080/14397595.2017.1361893.PubMed

Nagyova I, Stewart RE, Macejova Z, van Dijk JP, van den Heuvel WJ. The impact of pain on psychological well-being in rheumatoid arthritis: the mediating effects of self-esteem and adjustment to disease. Patient Educ Couns. 2005;58(1):55–62.CrossRefPubMed

10.

Sleath B, Chewning B, de Vellis BM, Weinberger M, de Vellis RF, Tudor G, et al. Communication about depression during rheumatoid arthritis patient visits. Arthritis Rheum. 2008;59(2):186–91.CrossRefPubMed

11.

Mattey DL, Dawes PT, Hassell AB, Brownfield A, Packham JC. Effect of psychological distress on continuation of anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. J Rheumatol. 2010;37(10):2021–4.CrossRefPubMed

12.

Kuwabara H, Saito Y, Mahlich J. Adherence and re-hospitalizations in patients with schizophrenia: evidence from Japanese claims data. Neuropsychiatr Dis Treat. 2015;11:935–40.PubMedPubMedCentral

13.

Davis K, Meyers J, Zhao Z, McCollam P, Murakami M. High-risk atherosclerotic cardiovascular disease in a real-world employed Japanese population: prevalence, cardiovascular event rates, and costs. Atheroscler Thromb. 2015;22(12):1287–304.CrossRef

14.

Rosenbaum P, Rubin D. Constructing a control group using multivariate matched sampling methods that incorporate the propensity score. Am Stat. 1985;39:33–8.

15.

Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005;43(11):1130–9.CrossRefPubMed

16.

Yamanaka H, Sugiyama N, Inoue E, Taniguchi A, Momohara S. Estimates of the prevalence of and current treatment practices for rheumatoid arthritis in Japan using reimbursement data from health insurance societies and the IORRA cohort (I). Mod Rheumatol. 2014;24(1):33–40.CrossRefPubMed

17.

Kawakami N. Epidemiology of depressive disorders in Japan and the world. Jpn J Clin Med. 2007;65(9):1578–84.

18.

Mahlich J, Tsukazawa S, Wiegand F. Estimating prevalence and health care utilization for treatment resistant depression in Japan: a retrospective claims database study. Drugs Real World Outcomes. 2017. https://doi.org/10.1007/s40801-017-0126-5.PubMedCentral

19.

Muramatsu K, Miyaoka H, Kamijima K, Muramatsu Y, Yoshida M, Otsubo T, et al. The patient health questionnaire, Japanese version: validity according to the Mini-International Neuropsychiatric Interview-Plus. Psychol Rep. 2007;101:952–60.PubMed

20.

Sruamsiri R, Kaneko Y, Mahlich J. The underrated prevalence of depression in patients with rheumatoid arthritis: evidence from a nationwide survey in Japan. BMC Rheumatol. 2017;1:5.CrossRef

21.

Nakajima A, Kamitsuji S, Saito A, Tanaka E, Nishimura K, Horikawa N, et al. Disability and patient’s appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan. Mod Rheumatol. 2006;16(3):151–7.CrossRefPubMed

22.

Sato E, Nishimura K, Nakajima A, Okamoto H, Shinozaki M, Inoue E, et al. Major depressive disorder in patients with rheumatoid arthritis. Mod Rheumatol. 2013;23(2):237–44.CrossRefPubMed

23.

Joyce AT, Smith P, Khandker R, Melin JM, Singh A. Hidden cost of rheumatoid arthritis (RA): estimating cost of comorbid cardiovascular disease and depression among patients with RA. J Rheumatol. 2009;36(4):743–52.CrossRefPubMed

24.

Mahlich J, Sruamsiri R. Preference for shared decision-making in Japanese patients with rheumatoid arthritis. Cogent Med. 2017;4:1353262.CrossRef

25.

Czwikla J, Domhoff D, Giersiepen K. ICD coding quality for outpatient cancer diagnoses in SHI claims data. Z Z Evid Fortbild Qual Gesundh wesen. 2016;118–119:48–55.CrossRef

26.

Manning W, Wells KB. The effects of psychological distress and psychological well-being on use of medical services. Med Care. 1992;30:541–53.CrossRefPubMed