3. Overview of Biologic Therapies
Author: Ronald F. van Vollenhoven
Publisher: Springer International Publishing
The discovery of the technology for producing monoclonal antibodies by Kohler and Milstein in 1975 heralded a new era in therapeutics: it became possible to design a molecule with a very specific predetermined biological effect for use in a relevant disease. Applications of the technology rapidly entered the medical fields of oncology and transplantation medicine.