Medicine Matters rheumatology

General risk factors

Disease-related risk factors

Maternal age

Comorbidities (overweight/obesity, arterial hypertension, diabetes mellitus, renal or thyroid disease)

Tobacco/alcohol use

Vaccination status

Previous adverse pregnancy outcomes

Disease activity status in the 6-12 months prior to conception

History of lupus nephritis

End-stage organ damage

Antiphospholipid antibodies profile

(high risk if persistent moderate-to-high aPL titres, LA and multiple aPL positivity)

Presence of anti-Ro/SSA and/or anti-La/SSB antibodies

Use of fetotoxic drugs

Table 2. Checklist of factors to be considered for preconception counselling in women with systemic lupus erythematosus. Adapted from Andreoli et al and Rodrigues et al.

aPL, antiphospholipid antibodies; LA, lupus anticoagulant.

Medicine Matters Rheumatology

Medicine Matters rheumatology