Skip to main content
main-content

Spondyloarthropathies

Pathophysiology

03-10-2018 | Ankylosing spondylitis | Article

Influence of HLA-B27 on the ankylosing spondylitis phenotype: Results from the REGISPONSER database

Arévalo M et al. Arthritis Res Ther 2018; 20: 221. doi: 10.1186/s13075-018-1724-7

03-08-2018 | Pathophysiology | Review | Article

S100 proteins in rheumatic diseases

Austermann J, Spiekermann C, Roth J. Nat Rev Rheumatol 2018. doi: 10.1038/s41584-018-0058-9

30-05-2018 | Enthesitis | Review | Article

Enthesitis: Much more than focal insertion point inflammation

Watad A et al. Curr Rheumatol Rep 2018; 20: 41. doi: 10.1007/s11926-018-0751-3

11-05-2018 | Axial spondyloarthritis | Review | Article

Axial disease in psoriatic arthritis and ankylosing spondylitis: A critical comparison

Feld J et al. Nat Rev Rheumatol 2018; 14: 363–371. doi: 10.1038/s41584-018-0006-8

16-04-2018 | Ankylosing spondylitis | Article

Functional defects of Treg cells: New targets in rheumatic diseases, including ankylosing spondylitis

Miao J & Zhu P. Curr Rheumatol Rep 2018; 20(5): 30. doi: 10.1007/s11926-018-0729-1

03-04-2018 | JAK inhibitors | Review | Article

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis

Veale DJ et al. Rheumatology (Oxford) 2018; Advance online publication. doi: 10.1093/rheumatology/key070

07-03-2018 | Pathophysiology | Review | Article

Role of human leukocyte antigens (HLA) in autoimmune diseases

Bodis G, Toth V, Schwarting A. Rheumatol Ther 2018; Advance online publication. doi: 10.1007/s40744-018-0100-z

23-02-2018 | Psoriatic arthritis | Review | Article

Psoriatic arthritis: Tissue-directed inflammation?

Cafaro G, McInnes IB. Clin Rheumatol 2018; Advance online publication. doi: 10.1007/s10067-018-4012-7

08-02-2018 | Pathophysiology | Review | Article

Proteinases and their receptors in inflammatory arthritis: An overview

Nat Rev Rheumatol 2018; 14: 170–180. doi: 10.1038/nrrheum.2018.17

24-08-2017 | Ankylosing spondylitis | Article

Transcriptome analysis of ankylosing spondylitis patients before and after TNF-α inhibitor therapy reveals the pathways affected

The authors find that tumor necrosis factor-α inhibitors exert a mild effect on the gene expression of patients with ankylosing spondylitis, including genes considered to be a genetic signature of the disease.

Genes Immun 2017;18:184–190. doi:10.1038/gene.2017.19

27-04-2017 | Ankylosing spondylitis | Review | Article

Pathogenesis of ankylosing spondylitis: Recent advances and future directions

The authors review the current knowledge of ankylosing spondylitis pathogenesis, including genetic risk associations, HLA-B27-mediated pathology, perturbations in antigen-presentation pathways, and the type 3 immune response.

Nat Rev Rheumatol 2017;13:359–367. doi:10.1038/nrrheum.2017.56

30-03-2017 | Ankylosing spondylitis | Review | Article

The paradox of bone formation and bone loss in ankylosing spondylitis: Evolving new concepts of bone formation and future trends in management

In this article, the authors briefly review the molecular mechanisms that lead to structural damage in ankylosing spondylitis and the impact of treatment with biologics to retard this process.

Magrey MN, Khan MA. Curr Rheumatol Rep 2017;19:17. doi:10.1007/s11926-017-0644-x

15-06-2017 | Ankylosing spondylitis | Review | Article

Pain in ankylosing spondylitis: A neuro-immune collaboration

Bidad et al. discuss the types of pain experienced in ankylosing spondylitis, insights from brain imaging studies, neurological mechanisms of pain, sex bias in pain, and how the immune system can modify pain.

Nat Rev Rheumatol 2017;13:410–420. doi:10.1038/nrrheum.2017.92

15-06-2017 | Genetics | Review | Article

Why location matters: Site-specific factors in rheumatic diseases

In this review, the authors discuss three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis.

Nat Rev Rheumatol 2017;13:433–442. doi:10.1038/nrrheum.2017.96

13-04-2016 | Ankylosing spondylitis | Review | Article

Autophagy in the pathogenesis of ankylosing spondylitis

This article explores the potential role of autophagy in the pathogenesis of ankylosing spondylitis as it affects the immune system and is implicated in several rheumatic disease processes.

Ciccia F & Haroon N. Clin Rheumatol 2016;35:1433–14363. doi:10.1007/s10067-016-3262-5

12-01-2016 | Psoriatic arthritis | Book Chapter | Article

Immunopathology of the psoriatic arthritis musculoskeletal lesions

Lymphocytes and dendritic cells play an important role in the pathogenesis of psoriatic arthritis. This chapter explores their role in the early and late phase of the disease.

de Vlam K. In: Psoriatic Arthritis and Psoriasis. Edited by Adebajo A et al. Springer International Publishing Switzerland, 2016. doi:10.1007/978-3-319-19530-8_7

12-01-2016 | Psoriatic arthritis | Book Chapter | Article

Mechanisms of bone remodelling in psoriatic arthritis

A review of advances in the understanding of bone homeostasis and abnormalities in the involved biological pathways in psoriatic arthritis, including the discovery of the interleukin-23/T helper 17 pathway.

Haroon N, Ritchlin C. In: Psoriatic Arthritis and Psoriasis. Edited by Adebajo A et al. Springer International Publishing Switzerland, 2016. doi:10.1007/978-3-319-19530-8_13

03-01-2016 | Psoriatic arthritis | Book Chapter | Article

Pathogenesis of psoriasis and psoriatic arthritis

Coates et al. discuss the etiology of psoriatic arthritis, including genetic and environmental factors. Various inflammatory pathways are also briefly discussed in this chapter.

In: Handbook of Psoriatic Arthritis and Psoriasis. Edited by Warren R, Menter A. Springer International Publishing Switzerland, 2016. doi:10.1007/978-3-319-18227-8_2

06-10-2015 | Ankylosing spondylitis | Review | Article

Genetics of ankylosing spondylitis—insights into pathogenesis

An overview of the future of ankylosing spondylitis genetics, including new developments in major histocompatibility complex (MHC) genetics, and progress in non-MHC genetics.

Nat Rev Rheumatol 2016;12:81–91. doi:10.1038/nrrheum.2015.133

07-05-2015 | Psoriatic arthritis | Review | Article

Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype

In this review, Fitzgerald et al discuss psoriatic arthritis pathogenesis in light of studies of human leukocyte antigen genotypes and a study on the relationship of genotype to phenotype.

FitzGerald O et al. Arthritis Res Ther 2015;17:115. doi:10.1186/s13075-015-0640-3

Image Credits