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10-04-2016 | Systemic lupus erythematosus | Book Chapter | Article

5. Autoantibodies and Biomarkers: Diagnostic Aspects

Authors: Savino Sciascia, Maria Laura Bertolaccini

Publisher: Springer International Publishing

Abstract

Autoantibodies, traditionally the hallmark of systemic lupus erythematosus (SLE), are typically present several years prior to diagnosis of SLE and serve as markers for future disease development in otherwise normal individuals. The methods for detecting autoantibodies play a crucial role in the diagnosis of SLE, as the particular assay used remarkably influences the interpretation of the test. In this chapter, we offer the reader an overview of the autoantibodies most commonly used in routine clinical practice.

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