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Adverse effects 

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  1. 28-11-2022 | Rheumatoid arthritis | News | Article

    Treatment goals in late-onset RA should match those for younger patients

    Given the potential adverse effects of prolonged glucocorticoid therapy, these findings suggest that when late-onset RA patients achieve remission, “the rheumatologist should re-evaluate the treatment regimen and readjust the regimen if necessary to make it safer in the long term,” they write.

  2. 01-11-2022 | Systemic lupus erythematosus | News | Article

    Dapagliflozin may warrant further investigation for SLE

    Half of the participants experienced adverse events (AEs), while 21% experienced AEs leading to treatment discontinuation.

  3. 26-09-2022 | Risk prediction | News | Article

    Local environment impacts recurrent hospitalization risk in rheumatic disease

    Feldman et al conclude: “The effects of our climate emergency will soon be more frequent and severe; it is imperative that we understand which populations of our patients with rheumatic disease are at greatest risk for avoidable adverse events, and the mechanisms that contribute to this heightened risk.”

  4. 15-09-2022 | Rheumatoid arthritis | Adis Journal Club | Article
    Drugs & Aging

    Difficult-to-Treat Rheumatoid Arthritis in Older Adults: Implications of Ageing for Managing Patients

    Age-related conditions can lead to patients classified as difficult to treat, owing to the need for frequent treatment changes in response to comorbidities or adverse effects.

  5. 12-09-2022 | Methotrexate | News | Article

    Methotrexate side effects more common in PsA than RA

    People initiating methotrexate for psoriatic arthritis report significantly more side effects during the first year of treatment than those given the drug for rheumatoid arthritis, US research shows.

  6. 30-08-2022 | COVID-19 | News | Article

    Studies bolster evidence for COVID-19 vaccination in young people with RMDs

    These AEs were “not unexpected as they are considered normal minor early side effects in the general population,” write the study authors in RMD Open .

  7. 05-08-2022 | JAK inhibitors | Video | Article

    Have the ORAL Surveillance results changed rheumatology practice?

    Following publication of the ORAL Surveillance trial, Richard Conway and Kevin Winthrop discuss the impact of the findings on JAK inhibitor prescribing, how regulatory recommendations compare in Europe and the USA, and whether the risks seen with tofacitinib represent a class effect.

  8. 12-08-2022 | Systemic lupus erythematosus | News | Article

    Pioglitazone may modulate CVD risk in patients with SLE

    Pioglitazone was well tolerated with 249 adverse events occurring at a similar rate with pioglitazone (52.6%) and placebo (47.4%).

  9. 05-08-2022 | Biologics | News | Article

    Support for long-term use of biologics in people with HIV

    Taken together, these findings suggest that biologics “provide a means for achieving symptomatic remission without major adverse opportunistic infections or any detrimental effects on CD4 counts or viral load,” write the authors in RMD Open .

  10. 26-07-2022 | Osteoarthritis | News | Article

    Botulinum toxin A injection may ease base-of-thumb osteoarthritis pain

    Nguyen and co-authors conclude: “Future studies are needed to investigate the potential mechanism of the effects observed in this trial, to replicate our findings, and to assess the effects of repeated injections over time and their clinical effectiveness, including an analysis of cost-effectiveness.”

  11. 03-06-2022 | Biosimilars | Adis Journal Club | Article
    Rheumatology and Therapy

    The Non-medical Switch from Reference Adalimumab to Biosimilar Adalimumab is Highly Successful in a Large Cohort of Patients with Stable Inflammatory Rheumatic Joint Diseases: A Real-Life Observational Study

    There were no objective changes in disease activity score in 28 joints using C-reactive protein (DAS28-CRP), or adverse effects before and after the switch between both groups.

  12. 06-05-2022 | Rheumatoid arthritis | News | Article

    Adding BTK inhibitor to upadacitinib offers no benefit in RA

    The investigators say that ABBV-599 was well tolerated overall, with treatment-emergent adverse events “generally balanced across treatment groups.”

  13. 05-04-2022 | Biosimilars | Adis Journal Club | Article
    BioDrugs

    Embracing Change: An International Survey Study on the Beliefs and Attitudes of Pediatric Rheumatologists Towards Biosimilars

    The major concerns regarding biosimilar prescription among pediatric rheumatologists are lack of available real-life data and insufficient information about the tolerance and adverse events in pediatric patients.

  14. 25-03-2022 | Systemic sclerosis | Adis Journal Club | Article
    Rheumatology and Therapy

    Photobiomodulation Therapy: A New Light in the Treatment of Systemic Sclerosis Skin Ulcers

    No procedural or post-procedural adverse events were reported.

  15. 30-03-2022 | Patient education | News | Article

    Nurse-led education may improve safety competency in biologic initiators

    “Prevention of [biologic] adverse effects is an important issue and is usually addressed by recommendations and training of rheumatologists and [healthcare professionals],” write Catherine Beauvais (Sorbonne Université, Paris) and co-authors in RMD Open .

  16. 01-04-2022 | Lupus nephritis | News | Article

    Trial supports tacrolimus as an alternative to cyclophosphamide for lupus nephritis

    Writing in JAMA Network Open , the investigators explain that “[c]ombination therapy with high-dose corticosteroids and intravenous cyclophosphamide is an established initial therapy among patients with LN,” but cyclophosphamide “is cytotoxic, and serious adverse effects have been observed during long-term treatment, including premature ovarian failure.”

  17. 16-08-2021 | Temporal cell arteritis | Teaser

    New additions to the Adis Journal Club

    A monthly selection of topical peer-reviewed articles from the Adis journals, curated by the editors.

  18. 10-03-2022 | Gout | News | Article
    News in brief

    Colchicine use linked to reduced risk for CKD progression

    Study findings published in Rheumatology show that long-term use of colchicine is associated with a decreased risk for adverse renal outcomes in people with hyperuricemia or chronic gout and stage G3–G4 chronic kidney disease.

  19. 02-02-2022 | Ankylosing spondylitis | Adis Journal Club | Article
    Advances in Therapy

    Disease Activity-Guided Stepwise Tapering but Not Discontinuation of Biologics Is a Feasible Therapeutic Strategy for Patients with Ankylosing Spondylitis: Real-World Evidence

    DOI [Teaser] Key Summary Points Given the high medical cost and adverse effects from long-term use of biosimilars, dose reduction and drug withdrawal have become a common concern for both doctor and the patient during ankylosing spondylitis (AS) treatment.

  20. 03-03-2022 | ANCA-associated vasculitis | News | Article

    Plasma exchange has mixed effects on ANCA-associated vasculitis outcomes

    Relapse rates, serious adverse event rates, and quality of life were not affected by PLEX, and the data suggest that its impact on both ESRD and serious infections falls over time.

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