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7 search results for:

Allopurinol hypersensitivity syndrome 

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  1. 30-10-2017 | Image

    Figure 2: Time elapsed (in days) from the start of allopurinol treatment to the occurrence of allopurinol hypersensitivity syndrome in patients with gout. [27]

  2. 25-04-2018 | Gout | News | Article

    Ethnicity may be a risk factor for allopurinol hypersensitivity

    People of Black, Asian, or Native Hawaiian/Pacific Islander ethnicity have a substantially higher risk for allopurinol-associated severe cutaneous adverse reactions than White and Hispanic individuals, US researchers report.

  3. 21-06-2018 | Gout | Review | Article

    Predicting response or non-response to urate-lowering therapy in patients with gout

    The authors review the extent of treatment success or failure with the xanthine oxidoreductase inhibitors allopurinol and febuxostat and indicate how the dosage of urate-lowering therapy may be modified to increase the response in the majority of patients with gout. Graham GG et al. Curr Rheumatol Rep 2018; 20: 47. doi: 10.1007/s11926-018-0760-2

  4. 21-06-2018 | Gout | Highlight | Teaser
    Journal article

    Predicting response or non-response to urate-lowering therapy in patients with gout

    The authors review the extent of treatment success or failure with the xanthine oxidoreductase inhibitors allopurinol and febuxostat and indicate how the dosage of urate-lowering therapy may be modified to increase the response in the majority of patients with gout [ read more ]. Graham GG et al. Curr Rheumatol Rep 2018; 20: 47. doi: 10.1007/s11926-018-0760-2

  5. 13-04-2018 | Allopurinol hypersensitivity syndrome | Article

    Racial/ethnic variation and risk factors for allopurinol-associated severe cutaneous adverse reactions: a cohort study

    Keller SF et al. Ann Rheum Dis 2018; Advance online publication. doi: 10.1136/annrheumdis-2017-212905

  6. 08-09-2016 | Gout | Article

    Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network meta-analysis

    However, patients taking allopurinol have a high risk of serious hypersensitivity syndromes, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, which may have a strong association with the HLA-B*5801 allele, a genetic change more commonly observed in Asian populations 19,54 .

  7. 29-09-2015 | Gout | Article

    Allopurinol hypersensitivity: investigating the cause and minimizing the risk

    This review examines allopurinol hypersensitivity, with a focus on risk factors and mechanisms, in the context of reducing the risk of this rare, but serious, adverse reaction. Nat Rev Rheumatol . 2016;12:235–242. doi: 10.1038/nrrheum.2015.132.

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