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Belimumab 

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  1. 01-08-2022 | Lupus nephritis | News | Article
    approvalsWatch

    FDA approves belimumab for pediatric lupus nephritis

    medwireNews : The US FDA has announced that the indication for belimumab will be expanded to include active lupus nephritis in children and adolescents aged 5–17 years.

  2. 08-07-2022 | Systemic lupus erythematosus | Adis Journal Club | Article
    PharmacoEconomics

    Belimumab for Treating Active Autoantibody-Positive Systemic Lupus Erythematosus: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

    In TA397, belimumab was approved, with a managed access arrangement (MAA), for adults only.

  3. 07-11-2021 | ACR 2021 | Conference coverage | Article

    Belimumab, arimoclomol disappoint in myositis trials

    Findings from two randomized controlled trials presented at the ACR Convergence 2021 virtual meeting suggest no significant benefits of treatment with the BAFF inhibitor belimumab or the heat shock response amplifier arimoclomol for patients with idiopathic inflammatory myopathy.

  4. 26-10-2021 | Systemic lupus erythematosus | News | Article

    Rituximab then belimumab may warrant further investigation for refractory SLE

    Following rituximab with the anti–B-cell activating factor monoclonal antibody belimumab may be a valid treatment option for patients with systemic lupus erythematosus that is refractory to conventional therapy, phase 2 study data suggest.

  5. 09-11-2021 | ACR 2021 | Conference coverage | Article

    BLISS-BELIEVE: Adding rituximab to belimumab does not improve SLE disease control

    Phase 3 trial findings presented at the ACR Convergence 2021 virtual meeting suggest that adding a single cycle of rituximab to belimumab therapy does not improve disease control rates among patients with systemic lupus erythematosus.

  6. 08-11-2021 | ACR 2021 | Conference coverage | Article

    Add-on treatment for lupus nephritis: Should belimumab or voclosporin be used first?

    Petri cautioned that it is currently unknown whether belimumab is appropriate to use during pregnancy, with an insufficient number of patients in the Belimumab Pregnancy Registry to draw any conclusions.

  7. 08-07-2021 | Systemic lupus erythematosus | News | Article

    EMBRACE: Support for belimumab benefits in people of Black African ancestry with SLE

    More patients of Black African ancestry with systemic lupus erythematosus respond to belimumab than placebo, but unlike in pivotal clinical trials, in which this group was underrepresented, the difference was not significant, say EMBRACE researchers.

  8. 04-06-2021 | EULAR 2021 | Conference coverage | Article

    Promise for belimumab, rituximab combination in patients with primary Sjögren's syndrome

    Subcutaneous belimumab combined with intravenous rituximab is well tolerated by patients with primary Sjögren's syndrome and shows positive signs of efficacy, suggest phase 2 study results.

  9. 29-03-2021 | Lupus nephritis | News | Article
    approvalsWatch

    EMA recommends approval of belimumab for lupus nephritis

    The efficacy of belimumab for lupus nephritis was demonstrated in the phase 3 BLISS-LN trial , in which adding belimumab to standard therapy improved renal outcomes.

  10. 18-01-2021 | Lupus nephritis | News | Article
    approvalsWatch

    FDA approves belimumab for lupus nephritis

    medwireNews : The US FDA has approved belimumab as the first drug treatment for adult patients with active lupus nephritis.

  11. 06-08-2020 | Systemic lupus erythematosus | News | Article

    Belimumab an ‘appropriate’ option for childhood-onset SLE

    The addition of belimumab to standard therapy improves response rates and has manageable toxicity in patients with childhood-onset systemic lupus erythematosus, suggest findings from the phase 2 PLUTO study.

  12. Efficacy and Safety of Intravenous Belimumab in Children with Systemic Lupus Erythematosus: An Across-Trial Comparison with the Adult Belimumab Studies

    The implication is that belimumab can be used in the pediatric population just as it is for adults

  13. 05-06-2020 | EULAR 2020 | Conference coverage | Article

    Belimumab shows promise for lupus nephritis

    Adding belimumab to standard therapy improves renal outcomes among patients with lupus nephritis, indicate findings from the BLISS-LN trial presented at the EULAR 2020 E-Congress.

  14. 01-05-2020 | Systemic lupus erythematosus | News | Article

    Disease characteristics predict belimumab response in SLE

    High disease activity, short disease duration, and low baseline damage are associated with an increased response to belimumab in patients with systemic lupus erythematosus, real world study data show.

  15. 17-10-2019 | Teaser
    ACR/ARP 2019 clinical trial recommendation

    Efficacy and Safety of Intravenous Belimumab in Children with Systemic Lupus Erythematosus: An Across-Trial Comparison with the Adult Belimumab Studies

    Wednesday,   November 13, 09:00–09:15. Georgia World Congress Center, Atlanta, USA Presenting author:  Antonio Nino, USA What our Editorial Board said: This trial is of interest because it shows that belimumab is effective for children with systemic lupus erythematosus. The implication is that belimumab can be used in the pediatric population just as it is for adults. –  Sangeeta Sule, USA

  16. 26-09-2019 | Systemic lupus erythematosus | News | Article
    approvalsWatch

    EMA gives nod to belimumab for children with lupus

    medwireNews : The EMA has recommended that the indication for belimumab should be expanded to include pediatric patients with systemic lupus erythematosus (SLE).

  17. 30-04-2019 | Systemic lupus erythematosus | News | Article
    approvalsWatch

    Belimumab approved for pediatric lupus in the USA

    The approval of belimumab highlights the collaborative efforts of the pediatric rheumatology community.

  18. 04-02-2019 | ANCA-associated vasculitis | News | Article

    Add-on belimumab does not reduce relapse risk in ANCA-associated vasculitis

    The addition of belimumab to maintenance therapy with azathioprine and low-dose glucocorticoids does not improve maintenance of remission among patients with antineutrophil cytoplasmic antibody-associated vasculitis, findings from the BREVAS trial suggest.

  19. 27-02-2019 | Systemic lupus erythematosus | News | Article

    Add-on belimumab efficacy maintained for up to 13 years in SLE patients

    Individuals with systemic lupus erythematosus who respond to belimumab plus standard of care therapy can hope to experience long-term disease control, suggests a trial in which participants received treatment for up to 13 years.

  20. 20-06-2018 | Systemic lupus erythematosus | EULAR 2018 | Article

    Encouraging long-term safety findings for belimumab in SLE

    Belimumab, a B-lymphocyte stimulator specific inhibitor used for the treatment of systemic lupus erythematosus, has a stable safety profile over 8 years of follow-up, with no new safety signals observed, report researchers.

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