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Biomarkers 

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  1. 07-11-2022 | Giant cell arteritis | News | Article

    Studies evaluate medications, biomarkers linked to GCA risk

    Wadström et al also carried out a hypothesis-generating investigation using principal component analysis to evaluate a wider range of biomarkers.

  2. 18-03-2022 | Polymyalgia rheumatica | News | Article

    Biomarkers may improve giant cell arteritis diagnosis

    Writing in Arthritis Research & Therapy , van Sleen and co-authors conclude that their study “provides robust evidence for more disease-specific biomarkers that may substantially improve diagnostic procedures for GCA patients.” medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group Arthritis Res Ther 2022; 24 : 65

  3. 16-06-2021 | Pediatric | News | Article

    Biomarkers may distinguish hyperinflammatory syndromes in children

    Two studies have identified serum biomarkers that could be used to differentiate between hyperinflammatory syndromes in children.

  4. 22-08-2019 | Rheumatoid arthritis | News | Article

    Neutrophil biomarkers show promise for predicting RA prognosis

    Neutrophil-derived biomarkers correlate with disease activity and can predict joint space narrowing and erosive disease among patients with rheumatoid arthritis, researchers report.

  5. 22-05-2018 | Systemic sclerosis | Review | Article

    Existing and novel biomarkers for precision medicine in systemic sclerosis

    The discovery and validation of biomarkers resulting from technological advances in the analysis of genomic, transcriptomic, lipidomic and

  6. 07-08-2017 | Vasculitis | Review | Article

    Vasculitis update: Pathogenesis and biomarkers

    Brogan & Eleftheriou summarize recent advances in the understanding of the pathophysiology of primary systemic vasculitides and the potential role of novel biomarkers discovered in that context.  Brogan P, Eleftheriou D. Pediatr Nephrol 2017. doi:10.1007/s00467-017-3597-4

  7. 15-06-2017 | Systemic lupus erythematosus | EULAR 2017 | Article
    EULAR 2017

    Potential biomarkers of pediatric lupus nephritis identified

    “Urinary biomarkers that reflect [lupus nephritis] activity and have prognostic value are much needed to guide the judicious use of immunosuppressive drugs in these patients,” said Patrícia Costa Reis, from the Children’s Hospital of Philadelphia in Pennsylvania, USA, and study co-authors in a poster presentation at the Annual European Congress of Rheumatology (EULAR) 2017 in Madrid, Spain.

  8. 07-03-2017 | Osteoporosis | Review | Article

    The utility of biomarkers in osteoporosis management

    This paper analyzes the most promising new bone marker candidates and reviews the clinical utility of classical and novel markers for the management of postmenopausal osteoporosis. Garnero P. Mol Diagn Ther 2017. doi:10.1007/s40291-017-0272-1

  9. 23-05-2018 | Osteoarthritis | Article

    Associations between molecular biomarkers and MR-based cartilage composition and knee joint morphology: Data from the Osteoarthritis Initiative

    Joseph GB et al. Osteoarthritis Cartilage 2018. doi: 10.1016/j.joca.2018.04.019

  10. 10-04-2016 | Systemic lupus erythematosus | Book Chapter | Article

    Autoantibodies and biomarkers: Diagnostic aspects

    Autoantibodies are normally present several years prior to systemic lupus erythematosus manifestations. This chapter reviews the autoantibodies most commonly used as diagnostic biomarkers in clinical practice. Sciascia S & Bertolaccini ML. In: Connective Tissue Disease . Edited by Roccatello D & Emmi L. Springer International Publishing Switzerland, 2016. doi:10.1007/978-3-319-24535-5_5

  11. 27-10-2016 | Rheumatoid arthritis | Review | Article

    Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers

    This review describes the pharmacokinetic properties and mechanism of action of methotrexate, knowledge of which could inform the development of biomarkers and enable targeted therapy.  Nat Rev Rheumatol 2016;12:731–742. doi:10.1038/nrrheum.2016.175

  12. 19-11-2015 | Systemic lupus erythematosus | Review | Article

    Anti-DNA antibodies — quintessential biomarkers of SLE

    Antibodies that recognize and bind to DNA are in regular use as biomarkers for diagnosis of systemic lupus erythematosus. This review highlights current and future challenges of such biomarkers.  Nat Rev Rheumatol 2016;12:102–110. doi:10.1038/nrrheum.2015.151

  13. 01-01-2015 | Osteoarthritis | Book Chapter | Article

    Osteoarthritis biomarkers

    Li et al. review the latest research into identifying osteoarthritis biomarkers that can capture the full spectrum of the pathogenesis of the condition and aid diagnosis. Li Y-H, Kim C, Gandhi R. In: Osteoarthritis . Edited by Kapoor M, Mahomed NN. Springer-International Publishing Switzerland, 2015. doi:10.1007/978-3-319-19560-5_9

  14. 06-07-2018 | Systemic lupus erythematosus | Article

    Diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus: A meta-analysis

    To systematically evaluate the diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus.

  15. 01-06-2015 | Rheumatoid arthritis | Review | Article

    Early biomarkers of joint damage in rheumatoid and psoriatic arthritis

    A discussion around recent developments in diagnostics and the importance of identifying patients susceptible to joint damage to support more informed and appropriate clinical decisions. Mc Ardle, A., Flatley, B., Pennington, S.R. et al. Arthritis Res Ther (2015) 17: 141. doi:10.1186/s13075-015-0652-z

  16. 27-10-2016 | Osteoarthritis | Article

    Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease

    The authors concluded that oxidized, nitrated, and glycated amino acids with hydroxyproline and anti-cyclic citrullinated peptide antibody status provide a test of high sensitivity and specificity for early-stage diagnosis of osteoarthritis. Ahmed U et al. Arthritis Res Ther 2016;18:250. doi:10.1186/s13075-016-1154-3

  17. 19-12-2022 | Systemic lupus erythematosus | News | Article

    Anti-dsDNA antibodies have potential to guide targeted therapy use in SLE

    Ehrenstein and colleagues also investigated potential biomarkers of unfavorable outcome, finding that interleukin (IL)-6 level at baseline was “the strongest negative predictor” of major clinical response at 1 year, irrespective of treatment allocation.

  18. 05-05-2015 | Axial spondyloarthritis | Review | Article

    Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis

    A review of the role of biomarkers in the management of ankylosing spondylitis and axial spondyloarthritis in diagnosis, determining disease activity, and predicting those at risk for a worse outcome. Reveille JD. Clin Rheumatol 2015;34:1009–1018. doi:10.1007/s10067-015-2949-3

  19. 06-12-2022 | Gout | News | Article

    CA72-4 independently associated with gout flare risk in people initiating ULT

    Results from a prospective cohort study suggest that increased levels of serum CA72-4 at urate-lowering therapy initiation are an independent risk factor for recurrent gout flares.

  20. 02-12-2022 | Systemic sclerosis | News | Article
    News in brief

    Anti-SSSCA1 positivity tied to cancer risk in SSc patients

    Study findings reported in Rheumatology suggest that anti-SSSCA1 antibodies may warrant further investigation as a biomarker for cancer risk among patients with systemic sclerosis.

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