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Colchicine 

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  1. 04-05-2022 | COVID-19 | News | Article
    News in brief

    Colchicine prophylaxis associated with ‘markedly reduced’ gout flare risk after COVID-19 vaccination

    COVID-19 vaccination with inactivated virus vaccines is associated with an increased risk for flares among men with gout, and colchicine prophylaxis may help reduce this risk, researchers report.

  2. 10-03-2022 | Gout | News | Article
    News in brief

    Colchicine use linked to reduced risk for CKD progression

    Study findings published in Rheumatology show that long-term use of colchicine is associated with a decreased risk for adverse renal outcomes in people with hyperuricemia or chronic gout and stage G3–G4 chronic kidney disease.

  3. 02-02-2022 | COVID-19 | Adis Journal Club | Article
    Rheumatology and Therapy

    Colchicine Against SARS-CoV-2 Infection: What is the Evidence?

    Colchicine is one of the oldest medicines with potent anti-inflammatory properties.

  4. 02-11-2021 | COVID-19 | News | Article

    RECOVERY: No evidence for colchicine benefit in COVID-19

    Colchicine, an anti-inflammatory drug commonly used to treat gout and pericarditis, does not improve outcomes for people hospitalized with COVID-19, RECOVERY trial data show.

  5. 05-02-2021 | COVID-19 | News | Article

    Colchicine may improve outcomes for hospitalized patients with COVID-19

    The addition of colchicine to standard treatment reduces the duration of supplemental oxygen therapy and time to hospital discharge among patients with moderate-to-severe COVID-19, suggest findings from a randomized controlled trial.

  6. 02-07-2020 | COVID-19 | News | Article

    Colchicine shows potential for COVID-19

    Preliminary findings from the GRECCO-19 trial suggest that colchicine, an anti-inflammatory drug used in the treatment of gout and familial Mediterranean fever, may have potential as a therapeutic agent for COVID-19.

  7. 11-11-2019 | Gout | News | Article

    Naproxen recommended over low-dose colchicine for gout flares

    Naproxen and low-dose colchicine are similarly effective in the reduction of pain associated with gout flares, but patients receiving colchicine tend to experience more side-effects, show results from the multicenter, open-label CONTACT trial.

  8. 14-03-2019 | Gout | News | Article
    approvalsWatch

    FDA approves oral colchicine for gout flare prophylaxis

    Oral colchicine has been approved by the US FDA for the prevention of flares in people with gout.

  9. 04-08-2022 | Gout | News | Article

    Gout flares linked to temporary increase in cardiovascular risk

    Jeffrey Anderson and Kirk Knowlton, both from Intermountain Medical Center in Salt Lake City, Utah, USA, say that the increased CV risk following flares, despite use of colchicine or other standard gout treatment, suggests “an opportunity for additional therapies to reduce risk of cardiovascular events,” such as more potent interleukin (IL)-1 inhibitors than those in current use, and agents targeting IL-18.

  10. 15-07-2022 | Gout | News | Article

    Study highlights sex-specific CVD risks in men with gout

    The team also found that men with gout who were not given colchicine had a significant 16% lower risk for CVD than those who received colchicine.

  11. 02-06-2022 | EULAR 2022 | Conference coverage | Article

    Topical alkalinizing treatment shows potential for acute gout

    The products were applied to the joint at the point of flare, alongside the initiation of colchicine (1.2 mg followed by 0.6 mg 1 hour later).

  12. 05-05-2022 | Gout | News | Article

    Support for gout self-management for improving urate levels

    They add: “The difference in flare frequency does not appear to be explained by differential use of regular colchicine,” which at 24 weeks was taken by 27% and 32% of participants who underwent self-monitoring and usual care, respectively.

  13. 03-02-2022 | Polyarthritis | Adis Journal Club | Article
    Rheumatology and Therapy

    A Patient with Symmetrical Polyarthritis. The Value of Conventional Radiography for a Correct Diagnosis

    There is no standard treatment for calcium pyrophosphate deposition disease, but colchicine and methotrexate have been proven to be helpful in some cases.

  14. 01-09-2021 | Gout | News | Article

    ELAG: Similar gout flare outcomes with early vs late allopurinol initiation

    Participants were aged a median of 62 years, and initial treatment for gout flare was similar in the early and late allopurinol groups, with colchicine taken by 41.3% and 45.6%, prednisolone by 31.0% and 38.6%, and nonsteroidal anti-inflammatory drugs by 27.6% and 15.8%, respectively.

  15. 07-05-2021 | Gout | Feature | Article

    Febuxostat and cardiovascular risk in people with gout

    In all, 32.4% of febuxostat-treated patients discontinued treatment, compared with 16.5% of those in the allopurinol group, and the FAST investigators speculate that this difference may have been due to higher rates of colchicine use in the febuxostat arm (3.6 vs 3.1%), or an increased likelihood of discontinuation due to switching from established allopurinol therapy.

  16. 17-09-2020 | COVID-19 | News | Article
    News in brief

    COVID-19: High rates of medication adherence in rheumatology patients

    Aida Malek Mahdavi and colleagues from Tabriz University of Medical Sciences in Iran found that among 858 rheumatology patients who took part in a telephone interview in July 2020, just 6.5% reported nonadherence to treatment, defined as a 20% or greater change in the dose or frequency of nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, glucocorticoids, conventional DMARDs, or biologics.

  17. 05-08-2019 | Behçet’s disease | News | Article

    Real-world data support apremilast for Behçet’s disease

    The study involved 12 individuals with recurrent or relapsing oral ulcers who had an inadequate response or intolerance to conventional treatment with corticosteroids and colchicine.

  18. 12-12-2018 | Gout | News | Article

    Hepatotoxicity reassurance for febuxostat-treated patients with gout and fatty liver disease

    Hong and team note that the mechanism linking colchicine treatment and hepatotoxicity “was unclear,” but “could be because colchicine [is] primarily metabolized and excreted by the liver.”

  19. 18-10-2018 | Crystal arthropathies | Case study | Article

    Hyperuricemia and chondrocalcinosis: A clinical challenge for diagnosis and treatment

    He had a typical history of gout of the metatarsophalangeal joint three years previously, and was on allopurinol 100 mg/day along with colchicine 0.5 mg/day intermittently.

  20. 17-01-2019 | Gout | News | Article

    Anakinra may be a ‘viable treatment option’ for gout

    Of the 45 patients allocated to the usual treatment group, 18 received colchicine (0.5 mg up to three times daily), 14 were given prednisone (35 mg/day), and 13 were given naproxen (500 mg up to twice daily); all treatments in this arm were administered orally.

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