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Gut microbiota 

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  1. 22-07-2016 | Juvenile idiopathic arthritis | Review | Article

    Gut microbiota-host interactions and juvenile idiopathic arthritis

    Arvonen et al. discuss the mechanisms by which the the microbiota may influence the risk of juvenile idiopathic arthritis and other systemic inflammatory conditions in children. Arvonen M et al. Pediatr Rheumatol 2016;14:44. doi:10.1186/s12969-016-0104-6

  2. 14-05-2021 | Psoriatic arthritis | News | Article

    Early data do not show fecal microbiota transplantation benefit in peripheral PsA

    Findings from a proof-of-concept study suggest that fecal microbiota transplantation may not be a suitable option for patients with active peripheral psoriatic arthritis but further investigation is still needed.

  3. 08-01-2021 | Rheumatoid arthritis | News | Article

    Gut microbiome may impact methotrexate response in RA

    Treatment-naïve people with new-onset rheumatoid arthritis who respond to treatment with methotrexate have consistent differences in their gut microbiomes relative to non-responders, study findings indicate.

  4. 12-01-2021 | Rheumatoid arthritis | Highlight | Teaser
    medwireNews top story

    Gut microbiome may impact methotrexate response in RA

    Treatment-naïve people with new-onset rheumatoid arthritis who respond to treatment with methotrexate have consistent differences in their gut microbiomes relative to non-responders, study findings indicate.

  5. 07-02-2020 | Spondyloarthropathies | Editorial | Article

    The microbiome in spondyloarthritis and its relationship with the IL-23/IL-17 axis

    Therefore, it is essential to investigate the association of gut microbiota and host genetics with spondyloarthritis pathogenesis.

  6. 07-02-2020 | Spondyloarthropathies | Highlight | Teaser
    Expert Opinion: Editorial

    The microbiome in spondyloarthritis and its relationship with the IL-23/IL-17 axis

    Tejpal Gill discusses the relationship between the microbiome and the IL-23/IL-17 axis in spondyloarthritis.

  7. 01-03-2019 | Juvenile idiopathic arthritis | Editorial | Article

    The microbiota in juvenile idiopathic arthritis: What’s wrong, and what can we do?

    In this editorial, Matthew Stoll explores the role of the microbiota in the pathogenesis of juvenile idiopathic arthritis, as well as current research into therapeutic alterations of the microbiome.

  8. 01-03-2019 | Juvenile idiopathic arthritis | Highlight | Teaser
    Expert opinion editorial

    The microbiota in juvenile idiopathic arthritis: What’s wrong, and what can we do?

    In this editorial, Matthew Stoll explores the role of the microbiota in the pathogenesis of juvenile idiopathic arthritis, as well as current research into therapeutic alterations of the microbiome.

  9. 18-10-2018 | Microbiome | Editorial | Article

    Why every rheumatologist should understand the microbiome

    How the gut microbiome interacts with the immune system By some parameters the gut, home to trillions of bacteria, is the largest organ in the immune system.

  10. 18-10-2018 | Microbiome | Highlight | Teaser
    Expert opinion editorial

    Why every rheumatologist should understand the microbiome

    James Rosenbaum and Mark Asquith discuss how the microbiome interacts with the immune system, how this may induce inflammation, and how the microbiome could be used as a therapeutic target for rheumatic diseases.

  11. 22-04-2017 | Microbiome | Article

    The role of the skin and gut microbiome in psoriatic disease

    This systematic review compared the microbiota of the skin and gut between patients with psoriasis and healthy controls. Yan D, Issa N, Afifi L, Jeon C, Chang H-W, Liao W. Curr Derm Rep  2017;6:94–103. doi:10.1007/s13671-017-0178-5

  12. 25-06-2018 | Systemic sclerosis | Review | Article

    Update on the gastrointestinal microbiome in systemic sclerosis

    Purpose of Review: Accumulating evidence suggests that gut microbiota affect the development and function of the immune system and may play a role in

  13. 23-02-2017 | Microbiome | Article

    The microbiome and systemic lupus erythematosus

    This review examines the relationship between intestinal microbiota and autoimmunity, with a focus on lupus, looking at the effect of the intestinal microbiota on disease and its potential role in therapy. Katz-Agranov N, Zandman-Goddard GZ.  Immunol Res  2017;65:432–437. doi:10.1007/s12026-017-8906-2

  14. 25-01-2017 | Microbiome | Article

    The intestinal microbiome, the immune system and spondyloarthropathy

    This chapter reviews the physiological processes involved in maintenance of intestinal homeostasis including the role of the microbiome, and discusses the role of dysbiosis in several disease states. Costella M-E, Brown MA. In Mina-Osorio P (Ed)  Next-generation therapies and technologies for immune-mediated inflammatory diseases, progress in inflammation research . 2017:145-165. doi:10.1007/978-3-319-42252-7_8

  15. 04-08-2016 | Microbiome | Article

    Microbiota and chronic inflammatory arthritis: an interwoven link

    This review outlines the role of the microbiota in the onset, severity and progression of inflammatory arthritis. Diamanti AP, Rosado MM, Laganà B, D’Amelio R.  J Transl Med  2016;14:233. doi 10.1186/s12967-016-0989-3

  16. 21-04-2016 | Microbiome | Article

    An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

    This study used fecal samples to investigate the gut microbial and metabolite profiles of patients with rheumatoid arthritis, compared with both first-degree relatives and with other healthy controls. Chen J, Wright K, Davis JM, et al. Genome Med  2016;8:43. doi:10.1186/s13073-016-0299-7

  17. Introduction

    Studies have demonstrated that the microbiota present in various regions, including the gut, skin and the mouth, in individuals with rheumatic diseases differs from that of healthy controls.

  18. 13-04-2017 | Diet and nutrition | Review | Article

    Dietary factors in rheumatic autoimmune diseases: A recipe for therapy?

    The authors review the evidence for the effects of several common dietary components on rheumatic diseases, suggesting a common denominator: these bioactive compounds have a role in shaping our gut microbiome. Nat Rev Rheumatol 2017;13:348–358. doi:10.1038/nrrheum.2017.42

  19. 27-10-2016 | Microbiome | Article

    Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors

    This study used fecal water metabolomics to identify mechanisms by which the altered microbiota in children with enthesitis-related arthritis might contribute to the pathogenesis of this disease. Genes Immun  2016;17:400–405. doi:10.1038/gene.2016.38

  20. 16-06-2016 | Microbiome | Review | Article

    How the microbiota shapes rheumatic diseases

    Beyond the gut: the skin microbiota The presence of bacteria in the human body is not limited to the gut.

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