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Heart failure 

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  1. 14-09-2022 | Systemic sclerosis | News | Article

    Systemic sclerosis linked to increased risk for heart failure

    People with systemic sclerosis have an approximately threefold increased risk for clinically evident heart failure compared with the general population, suggest the results of a cohort study.

  2. 15-07-2022 | Gout | News | Article

    Study highlights sex-specific CVD risks in men with gout

    Their findings are based on an analysis of national registry data for 942,416 residents of the Auckland/Northland region of Aotearoa New Zealand who were aged 20–79 years with no history of ischemic heart disease, ischemic or hemorrhagic stroke, transient ischemic attack, peripheral vascular disease, or heart failure.

  3. 07-03-2022 | COVID-19 | News | Article

    Gout linked to increased risk for COVID-19 diagnosis, mortality

    The study authors note that “[w]omen with gout have an elevated risk of metabolic comorbidities (hypertension, dyslipidaemia, type 2 diabetes, chronic kidney disease, obesity, coronary heart disease, cerebrovascular disease, and heart failure.”

  4. 09-11-2021 | ACR 2021 | Conference coverage | Article

    Statins show CVD benefits in RA with only a modest risk for new-onset diabetes

    The Hospital Episode Statistics and Office of National Statistics databases were then used to calculate incidence of CVD events, comprising a composite of nonfatal or fatal myocardial infarction, stroke, hospitalization for heart failure, or death from CVD, and all-cause mortality in one cohort of 1768 RA patients taking statins and 3528 patients not taking statins.

  5. 05-06-2021 | EULAR 2021 | Conference coverage | Article
    News in brief 

    CV risk similar for gout treatments allopurinol and benzbromarone

    The researchers also conducted a subanalysis of patients at high risk for CV disease but again there was no significant difference between the two groups for the composite outcome or its individual components, or for hospitalization for heart failure.

  6. 07-05-2021 | Gout | Feature | Article

    Febuxostat and cardiovascular risk in people with gout

    CARES FAST Number of participants 6190 6128 Eligibility criteria Patients with inadequately controlled gout and pre-existing cardiovascular disease Patients with gout and at least one additional CV risk factor Patient age Median 64.0 years (febuxostat group), 65.0 years (allopurinol group) Average 71.0 years Proportion of patients with history of CV disease 100% 33.4% Prior treatment 1–3 week washout from previous gout therapies Stable dose of allopurinol prior to study entry Treatment groups Febuxostat 40–80 mg/day or allopurinol (dosed according to kidney function) Febuxostat 80–120 mg/day or allopurinol at the optimized dose established prior to study entry Discontinuation rates 57.3% in the febuxostat arm, 55.9% in the allopurinol arm 32.4% in the febuxostat arm, 16.5% in the allopurinol arm Table: Summary of the study populations and treatment groups in the CARES and FAST trials Whereas the FAST trial included gout patients aged 60 years and older with at least one additional CV risk factor and excluded those with severe congestive heart failure or renal impairment, “it was a much higher risk population in the CARES trial,” he says, with all participants having a history of major CV disease prior to enrollment.

  7. 11-11-2020 | ACR 2020 | Conference coverage | Article

    ‘The Great Debate’: JAK inhibitors vs biologics following methotrexate failure in RA

    Weinblatt also said that hematologic toxicity occurs “extremely rarely” with TNF inhibitors, and there are rare cases of lupus-like syndrome, along with worsening of heart failure and skin cancer.

  8. 02-09-2020 | Rheumatoid arthritis | News | Article

    Abatacept, TNF inhibitors linked to reduced CVD risk in RA

    Overall, 1801 participants experienced the composite outcome of myocardial infarction, stroke, hospitalization for heart failure, or death from CVD during a median follow-up of 4 years, giving an incidence rate of 1.78 per 1000 person–years.

  9. 14-05-2020 | Pregnancy | Case study | Article

    My lupus patient wants to get pregnant: What next?

    In women of reproductive age, the ideal time for this evaluation is close to diagnosis, in order to set the timing for a future pregnancy and to avoid, if possible, drugs that can lead to premature gonadal failure such as cyclophosphamide.

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