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Intra-articular injections 

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  1. 27-09-2022 | Osteoarthritis | News | Article

    Study questions long-term benefits of recurrent intra-articular steroid injections

    Recurrent intra-articular corticosteroid injections are often inferior to other injectables, including placebo, for the long-term improvement of pain, function, and quality of life in people with osteoarthritis, meta-analysis data suggest.

  2. 20-02-2019 | Osteoarthritis | News | Article

    Repeat intra-articular corticosteroid injections feasible for knee OA patients

    The study included 208 participants who were given an intra-articular injection of the microsphere-based formulation of TA at a dose of 32 mg, followed by a second injection 12, 16, 20, or 24 weeks later.

  3. 17-05-2017 | Osteoarthritis | News | Article

    Intra-articular steroid injections not supported for knee OA

    Results of a randomized trial suggest no clinical benefits of triamcinolone injections for patients with symptomatic knee osteoarthritis.

  4. 14-09-2018 | Osteoarthritis | Article

    Evaluating the use of intra-articular injections as a treatment for painful hip osteoarthritis: A randomized, double-blind, multicenter, parallel-group study comparing a single 6-mL injection of hylan G-F 20 with saline

    Brander V et al. Osteoarthritis Cartilage 2018. doi: 10.1016/j.joca.2018.08.018

  5. 26-07-2022 | Osteoarthritis | News | Article

    Botulinum toxin A injection may ease base-of-thumb osteoarthritis pain

    Intra-articular injection with botulinum toxin A results in clinically meaningful pain reduction for up to 3 months in people with base-of-thumb osteoarthritis, French study findings indicate.

  6. 22-07-2022 | Osteoarthritis | News | Article
    News in brief

    Meta-analysis does not support viscosupplementation for knee osteoarthritis

    Bruno da Costa (University of Toronto, Ontario, Canada) and co-authors analyzed data from 25 placebo-controlled trials including a total of 9423 patients, finding that viscosupplementation – defined as intra-articular injection with any hyaluronic acid preparation or a hyaluronic acid derivative – achieved a “small, non-clinically relevant” decrease in pain intensity.

  7. 19-04-2022 | Osteoarthritis | News | Article

    Intramuscular glucocorticoid injection ‘considered effective’ for knee OA pain

    Intramuscular glucocorticoid injection is noninferior to intra-articular injection for reducing knee pain after 8 and 24 weeks in patients with knee osteoarthritis, but may be inferior at 4 weeks, research shows.

  8. 26-11-2021 | Osteoarthritis | News | Article

    RESTORE trial suggests no benefit of platelet-rich plasma injections for knee OA

    Intra-articular injections of platelet-rich plasma do not reduce knee pain or disease progression for people with symptomatic mild-to-moderate radiographic medial knee osteoarthritis, suggest findings from a randomized controlled trial.

  9. 29-10-2021 | Osteoarthritis | News | Article
    News in brief

    Platelet-rich plasma injections not supported for ankle osteoarthritis

    Findings from the PRIMA trial suggest no benefit of intra-articular platelet-rich plasma injections for people with ankle osteoarthritis.

  10. 16-01-2022 | Hyaluronic acid injection | Adis Journal Club | Article
    Advances in Therapy

    Hyaluronic Acid Therapy in Hip OA Does Not Perform Equally in Osteoarthritis Secondary to Juvenile Idiopathic Arthritis When Compared to Primary Osteoarthritis: A 2-Year Preliminary Evaluation

    Duration of symptom relief after intra-articular injection of hyaluronic acid depends on the nature of hip osteoarthritis (OA) Different clinical response depends on the characteristic features of synovial environment in patients suffering from inflammatory rheumatological conditions A different therapeutic schedule for HA intra-articular injections may be necessary in patients affected by JIA

  11. 08-06-2021 | Intra-articular injections | News | Article
    guidelinesWatch

    ​​​​​​​EULAR issues recommendations on intra-articular therapies

    EULAR has developed evidence-based recommendations on the use of intra-articular therapy in adult patients with peripheral arthropathies.

  12. 13-04-2021 | Osteoarthritis | News | Article

    Sprifermin benefits may be greatest in knee osteoarthritis patients at risk for progression

    In the first study, Guo-Xin Ni and colleagues from The First Affiliated Hospital of Fujian Medical University in Fuzhou, China, conducted a meta-analysis of eight randomized placebo-controlled trials evaluating intra-articular sprifermin injections in KOA patients with a follow-up duration of 6 months–3 years.

  13. 09-04-2020 | Osteoarthritis | Highlight | Teaser
    medwireNews top story

    ​​​​​​​Support for physical therapy over glucocorticoid injections for knee osteoarthritis

    People with symptomatic knee osteoarthritis who undergo physical therapy have greater reductions in pain and functional disability over 1 year than those given intra-articular glucocorticoid injections, randomized trial results suggest.

  14. 09-04-2020 | Osteoarthritis | News | Article

    ​​​​​​​Support for physical therapy over glucocorticoid injections for knee osteoarthritis

    People with symptomatic knee osteoarthritis who undergo physical therapy have greater reductions in pain and functional disability over 1 year than those given intra-articular glucocorticoid injections, randomized trial results suggest.

  15. 15-06-2018 | Osteoarthritis | Article

    Long-term effectiveness of intraarticular injections on patient-reported symptoms in knee osteoarthritis

    Liu SH et al. J Rheumatol 2018. doi: 10.3899/jrheum.171385

  16. 08-01-2020 | Psoriatic arthritis | Feature | Article
    Updated November 2020

    ​​​​​​​At a glance: Phase 3 trials of IL-17A inhibitors in PsA

    SPIRIT-P2 Patient population Treatment groups Status Active PsA and an inadequate response or intolerance to prior treatment with TNF inhibitors Subcutaneous injections of ixekizumab at a starting dose of 160 mg followed by 80 mg every 2 weeks (n=123) or every 4 weeks (n=122), or placebo (n=118) Published https://clinicaltrials.gov/ct2/show/NCT02349295 The SPIRIT-P2 results were reported in The Lancet in 2017.

  17. 26-03-2019 | Teaser

    Appreciate the uniqueness of the temporomandibular joint (TMJ). Appreciate that caution is needed for using intra-articular corticosteroid injections in the TMJ. Understand that treatment of TMJ arthritis and TMJ involvement in JIA includes a multidisciplinary approach.

  18. 09-03-2020 | Osteoarthritis | News | Article

    Additional FORWARD data support sprifermin as a disease-modifying osteoarthritis drug

    For the study, 434 patients aged 40–85 years with symptomatic knee OA were randomly assigned to receive three once-weekly intra-articular injections of sprifermin at a dose of 30 µg every 6 months (n=83), 30 µg every 12 months (n=92), 100 µg every 6 months (n=86), or 100 µg every 12 months (n=90), while the remaining 83 patients received placebo.

  19. 16-03-2018 | Osteoarthritis | News | Article

    Factors identified to predict knee OA benefits with IAHA injections

    Researchers have identified some reliable determinants for predicting which patients with knee osteoarthritis are most likely to benefit from intra-articular hyaluronic acid injections.

  20. 07-11-2017 | Osteoarthritis | ACR/ARHP 2017 | Article
    News in brief

    Higher risk for knee OA progression with corticosteroid injections

    Results of an observational study suggest that intra-articular corticosteroid injections are associated with an increased risk for progression of knee osteoarthritis.

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