Metformin use is associated with a significant reduction in the risk for total knee or hip replacement among people with type 2 diabetes, shows research published in CMAJ .

Metformin does not reduce uric acid levels or inflammation in gout patients with comorbid diabetes, research suggests.

Findings from a proof-of-concept phase 2 study suggest that treatment with the antidiabetes drug metformin could help minimize some metabolic complications and improve clinical outcomes for patients taking systemic glucocorticoid therapy.

Findings from a proof-of-concept phase 2 study suggest that treatment with the antidiabetes drug metformin could help minimize some metabolic complications and improve clinical outcomes for patients taking systemic glucocorticoid therapy.

A randomized controlled trial has demonstrated uncertain benefits of the antidiabetes drug metformin when added to standard therapy in patients with systemic lupus erythematosus, but the researchers believe that further investigation of the drug is warranted for the reduction of major flares.

Metformin use may protect against knee cartilage damage in obese people with knee osteoarthritis, suggests an analysis of Osteoarthritis Initiative participants.

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All participants were undergoing treatment with antidiabetic medications, with 74.4% taking oral drugs (primarily metformin), and 25.6% given insulin.

The studies covered interventions for weight loss, including diet, physical activity, and bariatric surgery, in addition to unintentional weight loss that occurred as a result of consuming a high-protein diet or treatment with metformin or diuretics.

Weight loss occurred as a result of diet with or without physical activity, bariatric surgery, diuretics, metformin, or no intervention in the included studies, said Nielsen.