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507 search results for:

Methotrexate 

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  1. 21-11-2022 | ACR 2022 | Conference coverage | Article

    Abortion restrictions impede methotrexate access for some rheumatology patients

    Patients with rheumatic diseases have reported issues with access to methotrexate following changes to abortion laws, show findings from a questionnaire study conducted in the USA.

  2. 12-09-2022 | Methotrexate | News | Article

    Methotrexate side effects more common in PsA than RA

    People initiating methotrexate for psoriatic arthritis report significantly more side effects during the first year of treatment than those given the drug for rheumatoid arthritis, US research shows.

  3. 04-07-2022 | Rheumatoid arthritis | News | Article

    Ozoralizumab shows promise in methotrexate-resistant RA

    The next-generation anti-tumor necrosis factor-alpha antibody ozoralizumab significantly improves clinical signs and symptoms of rheumatoid arthritis relative to placebo in people with active disease despite methotrexate therapy, research suggests.

  4. 12-07-2022 | Rheumatoid arthritis | News | Article

    Background methotrexate may boost placebo response in RA trials

    Background therapy with methotrexate may partly explain placebo responses observed in rheumatoid arthritis clinical trials, study findings indicate.

  5. 30-06-2022 | COVID-19 | News | Article

    VROOM trial: Pausing methotrexate doubles antibody response to COVID-19 booster vaccine

    Holding methotrexate treatment for 2 weeks following administration of a booster dose of vaccines against SARS-CoV-2 significantly improves the humoral immune response to vaccination, suggest findings from a randomized controlled trial.

  6. 02-06-2022 | EULAR 2022 | Conference coverage | Article

    TREAT EARLIER: RA delayed with methotrexate in arthralgia patients

    Temporary methotrexate treatment in patients with arthralgia may delay the onset of clinical rheumatoid arthritis and reduce disease burden, researchers have found.

  7. 02-06-2022 | EULAR 2022 | Conference coverage | Article

    Methotrexate add-on therapy boosts pegloticase efficacy in refractory gout

    The addition of methotrexate to pegloticase for the treatment of uncontrolled gout improves the rate of sustained urate-lowering response over 6 months, show findings from the MIRROR randomized controlled trial.

  8. 04-06-2022 | EULAR 2022 | Conference coverage | Article

    Support for pausing methotrexate only after second COVID-19 vaccine dose

    Pausing methotrexate only after the second dose of a COVID-19 vaccine may provide the best balance between antibody response and risk for flare, findings from two randomized controlled trials suggest.

  9. 09-06-2022 | EULAR 2022 | Conference coverage | Article

    Reduced methotrexate dose noninferior to higher dose at adalimumab initiation in RA

    Findings from the MIRACLE study indicate that patients with rheumatoid arthritis and inadequate response to methotrexate who receive a reduced dose of methotrexate at adalimumab initiation have comparable remission outcomes to those given the maximum tolerable dose, and may have fewer adverse events.

  10. 08-03-2022 | COVID-19 | News | Article

    Temporary methotrexate withdrawal may improve COVID-19 vaccine immunogenicity

    Findings from the CoronavRheum trial suggest that suspension of methotrexate for 2 weeks after each dose of the Sinovac inactivated SARS-CoV-2 vaccine may improve antibody response rates to vaccination among people with rheumatoid arthritis.

  11. 04-03-2022 | Psoriatic arthritis | News | Article

    COMPLETE-PsA: Adding leflunomide to methotrexate may improve outcomes

    The addition of leflunomide to methotrexate monotherapy results in significant improvements in disease activity among people with active psoriatic arthritis, suggest findings from the COMPLETE-PsA trial.

  12. 09-11-2021 | ACR 2021 | Conference coverage | Article

    No benefit to methotrexate use with ustekinumab in PsA

    People initiating the IL-12/23 inhibitor ustekinumab for active psoriatic arthritis achieve similar outcomes irrespective of whether the drug is given with or without methotrexate, show data presented at the ACR Convergence 2021 virtual meeting.

  13. 09-11-2021 | ACR 2021 | Conference coverage | Article

    Olokizumab benefits extend to patients with RA refractory to methotrexate or TNF inhibitors

    Olokizumab shows clinical and physical benefits for patients with rheumatoid arthritis with inadequate responses to methotrexate and TNF inhibitor therapy in the latest CREDO findings.

  14. 01-07-2021 | Rheumatoid arthritis | News | Article

    Early RA methotrexate benefits dampened by smoking

    Cigarette smoking among people with early rheumatoid arthritis significantly reduces the clinical benefit of methotrexate – in a dose-dependent manner – regardless of whether concomitant prednisone is used, researchers report.

  15. 13-07-2021 | COVID-19 | News | Article

    Methotrexate dulls humoral but not cellular response to COVID-19 vaccine

    UK research suggests there is a disparity between humoral and cellular immune responses to the first dose of the Pfizer–BioNTech COVID-19 vaccine in people on methotrexate monotherapy for psoriasis.

  16. 05-06-2021 | EULAR 2021 | Conference coverage | Article

    Levilimab–methotrexate combination improves RA response rates

    The addition of levilimab to methotrexate improves response rates among patients with rheumatoid arthritis who are resistant to methotrexate, show phase 3 SOLAR data presented in a poster at the EULAR 2021 Virtual Congress.

  17. 25-05-2021 | COVID-19 | News | Article

    Methotrexate may impair immune response to COVID-19 vaccination

    Some patients with immune-mediated inflammatory diseases treated with methotrexate may have a blunted immune response to mRNA vaccines against SARS-CoV-2, researchers report.

  18. 27-04-2021 | BSR 2021 | Conference coverage | Article

    Predictors of methotrexate-related adverse events described in RA patients

    Research presented at the online British Society for Rheumatology 2021 Annual Conference has identified predictors of adverse events in people with rheumatoid arthritis receiving treatment with methotrexate.

  19. 12-04-2021 | Rheumatoid arthritis | News | Article

    Similar rheumatoid arthritis outcomes with oral vs subcutaneous methotrexate

    Real-world study results suggest that patients with rheumatoid arthritis who initiate treatment with oral methotrexate achieve similar disease control to those taking the subcutaneous formulation.

  20. 16-04-2021 | Rheumatoid arthritis | News | Article

    Real-world data reinforce benefit of optimizing methotrexate before starting biologics

    Patients with rheumatoid arthritis who have an inadequate response to initial methotrexate therapy achieve comparable improvements in disease activity with treatment optimization as with biologic DMARD therapy initiation, suggest data from the STRATEGE study.

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