These findings suggest that “[r]andomized controlled clinical trials in patients with osteoarthritis [OA] are warranted to determine whether metformin is effective in decreasing the need for joint replacement,” say Changhai Ding (Zhujiang Hospital, Southern Medical University, Guangzhou, China) and colleagues.

A diet and exercise program delivered in community settings may improve some clinical outcomes for people with knee osteoarthritis and overweight or obesity, suggest findings from the WE-CAN pragmatic randomized controlled trial.

Early trial results suggest that ultrasound-guided genicular nerve block may represent a promising short-term treatment option for pain associated with knee osteoarthritis.

The PARTNER model of primary care delivery for patients with knee osteoarthritis may improve knee pain and function over that achieved by general practitioner care alone, say Australian researchers.

People with knee osteoarthritis may experience modest improvements in physical function while following a 12-week self-guided online yoga program, but the benefits are not sustained when the exercise is stopped, researchers report.

A reduction in BMI is associated with a lower risk for onset and progression of the structural defects of knee osteoarthritis, indicate findings from a multicohort study.

Findings from a systematic review and meta-analysis indicate that viscosupplementation does not significantly improve pain and physical function in people with knee osteoarthritis, but increases the risk for serious adverse events.

Intra-articular injection with botulinum toxin A results in clinically meaningful pain reduction for up to 3 months in people with base-of-thumb osteoarthritis, French study findings indicate.

Results from a post-hoc analysis suggest that increased dietary vitamin K intake is associated with greater improvement in symptoms among patients with knee osteoarthritis, warranting further examination in clinical trials.

Findings from an observational study suggest that walking for exercise is associated with a reduced risk for developing frequent knee pain among people aged 50 years and older with knee osteoarthritis.

The tumor necrosis factor inhibitor adalimumab does not improve pain or function in people with knee osteoarthritis, indicate phase 2 trial results.

Polygenic risk scores for advanced knee and hip osteoarthritis are significantly associated with the likelihood of requiring joint replacement in community-dwelling older adults, Australian study findings indicate.

The number of people living with osteoarthritis worldwide has more than doubled since 1990, show data from the Global Burden of Disease study 2019.

A single ultrasound-guided corticosteroid and local anesthetic intra-articular hip injection offers greater pain relief to people with moderate hip osteoarthritis than the best current treatment of advice and education, research suggests.

Findings from a randomized controlled trial suggest that weight-loss surgery may negate the need for total knee arthroplasty for some people with severe obesity and knee osteoarthritis.

Higher BMI is associated with increased hand pain in people with hand osteoarthritis, which researchers suggest could be partly mediated by increased leptin levels.

As current literature lacks studies valuating medical management of osteoarthritis (OA) secondary to JIA, we assessed the long-term pain relief effect of US-guided intra-articular viscosupplementation in hip osteoarthritis secondary to JIA versus primary OA under different etiological conditions.

Adding duloxetine to usual care does not improve pain outcomes for people with chronic osteoarthritis, suggest findings from a randomized controlled trial conducted in the primary care setting.

Overweight or obese people with knee osteoarthritis may benefit from a diet- and exercise-focused telehealth intervention, which researchers have shown can improve pain and function over 6 months.

People with osteoarthritis  who undergo total knee replacement may have a lower risk for major adverse cardiovascular events  and mortality than those who do not, researchers report.