Treatment with zoledronate once every 18 months significantly reduces the risk for nonvertebral or vertebral fragility fractures, compared with placebo, in postmenopausal women with osteopenia, study findings indicate.

Treatment with zoledronate once every 18 months significantly reduces the risk for nonvertebral or vertebral fragility fractures, compared with placebo, in postmenopausal women with osteopenia, study findings indicate.

Just under half (49%) had osteopenia and 22% had osteoporosis; 31% had fragility fractures.

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Zoledronic acid treatment for 6 years significantly lowered the risk for clinical, clinical vertebral, and nonvertebral fractures compared with placebo among women with osteopenia or osteoporosis, while 4–8 years of raloxifene was associated with a significant reduction in the risk for clinical and radiographic vertebral fractures, but not nonvertebral or hip fractures.

Moreover, the term “osteopenia” should not appear in pediatric DXA reports, and the term “osteoporosis” should not appear in such reports unless there is a clinically significant fracture history.