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Prednisolone 

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  1. 17-11-2020 | Axial spondyloarthritis | News | Article

    Mixed results for prednisolone in axial spondyloarthritis

    Treatment with oral prednisolone on a step-down regimen may reduce disease activity in people with axial spondyloarthritis but has minimal impact on other outcomes such as functional improvement, Indian researchers report.

  2. 11-11-2019 | Osteoarthritis | ACR/ARP 2019 | Article

    Short-term prednisolone offers HOPE for painful hand osteoarthritis

    Findings from the HOPE trial indicate that short-term treatment with prednisolone may provide pain relief for patients with hand osteoarthritis experiencing a flare following withdrawal of NSAIDs.

  3. 07-04-2017 | Rheumatoid arthritis | Article

    Diagnostic value of a 3-day course of prednisolone in patients with possible rheumatoid arthritis: The TryCort study

    The results of the TryCort study demonstrate that the prednisolone test had a moderate sensitivity and a good specificity in differentiating between rheumatoid arthritis and hand osteoarthritis. Kiltz U, von Zabern C, Baraliakos X et al. Arthritis Res Ther 2017;19:73. doi:10.1186/s13075-017-1279-z

  4. 10-11-2022 | Systemic lupus erythematosus | News | Article

    Achieving LLDAS tied to reduced mortality risk in SLE

    A similar association was observed for being in remission for at least half the time (HR=0.52), when remission was defined as a clinical SLEDAI score of 0, a physician global assessment score of less than 0.5, prednisolone dose of 5 mg/day or less, and use of antimalarials and standard maintenance doses of immunosuppressants.

  5. 01-11-2022 | Systemic lupus erythematosus | News | Article

    Dapagliflozin may warrant further investigation for SLE

    The average daily dose of prednisolone decreased significantly during this period, from 14.21 to 10.67 mg, which the researchers say is “compatible with standard-of-care tapering.”

  6. 20-09-2022 | Rheumatoid arthritis | News | Article
    News in brief

    Study identifies risk factors for mortality in RA-ILD

    Older age and higher daily prednisolone-equivalent dose were also significantly associated with mortality risk.

  7. 03-06-2022 | EULAR 2022 | Conference coverage | Article

    Chronic, low-dose glucocorticoid benefits outweigh harms in senior patients with RA

    This compared with 31% of 100 patients given placebo, giving a nonsignificant 43% increased risk for the prednisolone group.

  8. 03-06-2022 | EULAR 2022 | Conference coverage | Article

    Evidence for baricitinib efficacy in SLE ‘remains inconclusive’

    The patients were stratified based on baseline disease activity, prednisolone dose, and geographic region, and were allowed to continue background standard-of-care medications, “but glucocorticoid taper was strongly encouraged with a goal of 7.5 mg of prednisolone or less by week 40,” Morand reported.

  9. 06-06-2022 | EULAR 2022 | Conference coverage | Article

    DMARD treatment has ‘profound anticoagulant effects’ in early RA

    Bas Dijkshoorn (Amsterdam Rheumatology and Immunology Center, the Netherlands) and colleagues analyzed data from 24 Dutch patients who participated in NORD-STAR , a randomized trial comparing conventional treatment (n=5; either prednisolone or sulfasalazine combined with hydroxychloroquine and intra-articular corticosteroids) with certolizumab pegol (n=6), abatacept (n=7), or tocilizumab (n=6), all given alongside methotrexate, in patients with newly diagnosed RA.

  10. 04-06-2022 | EULAR 2022 | Conference coverage | Article

    Support for pausing methotrexate only after second COVID-19 vaccine dose

    They conducted two studies – MIVAC I and MIVAC II –  in unvaccinated patients with rheumatoid arthritis or psoriatic arthritis who had been on a stable dose of methotrexate for at least 6 weeks and a maximum prednisolone dose of 5 mg/day.

  11. 24-03-2022 | Kawasaki disease | News | Article

    Network meta-analysis rates treatments for Kawasaki disease

    Adding infliximab to standard therapy with high-dose intravenous immunoglobulin plus high-dose aspirin may decrease fever duration and prevent coronary artery lesions in children with Kawasaki disease, study findings indicate.

  12. 21-10-2021 | Infection | News | Article

    TNF inhibitors linked to more serious infections in RA vs PsA

    “However, the additive effect of multiple risk factors in the RA population, including more frequent prednisolone use, may explain some of the increased risk of [serious infections] in patients with RA,” Christensen and co-authors write.

  13. 10-11-2021 | ACR 2021 | Conference coverage | Article

    IL-17A inhibition demonstrates potential for giant cell arteritis

    Both treatments were given alongside a 26-week prednisolone tapering regimen, with the dose decreasing from 25–60 mg at baseline to 0 mg at the end of the taper period.

  14. 06-12-2021 | Abatacept | News | Article

    Abatacept may be beneficial for some patients with IgG4-related disease

    Stone et al note that just one of the participants with a disease response at week 24 was treated with prednisolone earlier in the study.

  15. 12-10-2021 | Lupus nephritis | News | Article

    Add-on obinutuzumab shows promise for proliferative lupus nephritis

    Findings from the phase 2 NOBILITY trial suggest that the addition of the type II anti-CD20 antibody obinutuzumab to standard therapy may improve renal outcomes for patients with proliferative lupus nephritis.

  16. 07-11-2021 | ACR 2021 | Conference coverage | Article

    High rates of severe COVID-19 in patients with vasculitis, polymyalgia rheumatica

    Moreover, men had a significantly higher likelihood of experiencing worse COVID-19 outcomes than women (OR=1.38), as did people with moderate, high, or severe vasculitis or PMR disease activity (OR=2.12 vs remission) and those on glucocorticoids at a prednisolone-equivalent dose of at least 10 mg/day (OR=2.14 vs none).

  17. 12-11-2021 | ACR 2021 | Conference coverage | Article

    Telemedicine feasible for delivery of SLE follow-up care

    There was also no significant difference in the mean 24-hour proteinuria level or prednisolone dose between the two groups at the last visit.

  18. 18-05-2021 | Lupus nephritis | News | Article

    AURORA 1: Voclosporin improves renal outcomes in patients with lupus nephritis

    Adding the calcineurin inhibitor voclosporin to background immunosuppressive therapy improves renal response rates among people with lupus nephritis, show phase 3 trial results published in The Lancet .

  19. 30-09-2021 | Polymyalgia rheumatica | News | Article

    ‘Encouraging’ results for rituximab in patients with polymyalgia rheumatica

    For the study, 47 patients with recently diagnosed PMR (n=38) or relapsing disease on at least 7.5 mg/day of prednisolone (n=9) were randomly assigned to receive either a single infusion of rituximab 1000 mg or placebo, together with a 17-week glucocorticoid treatment with taper to 0 mg.

  20. 01-09-2021 | Gout | News | Article

    ELAG: Similar gout flare outcomes with early vs late allopurinol initiation

    Participants were aged a median of 62 years, and initial treatment for gout flare was similar in the early and late allopurinol groups, with colchicine taken by 41.3% and 45.6%, prednisolone by 31.0% and 38.6%, and nonsteroidal anti-inflammatory drugs by 27.6% and 15.8%, respectively.

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