Hasan Yazici, Emire Seyahi, Gulen Hatemi, Yusuf Yazici
Behçet syndrome: a contemporary view
In this review, the authors discuss the emerging, most-recent evidence on the etiology, manifestations and epidemiology of Behçet syndrome [read more]. Nat Rev Rheumatol 2018; 14: 107–119. doi: 10.1038/nrrheum.2017.208
This review discusses the pathogenic functions of immune semaphorins, as well as the potential use of these molecules as diagnostic markers and therapeutic targets for the treatment of autoimmune diseases.
The authors propose that it has been difficult to identify clinically meaningful effects of targeted biologic therapies in giant cell arteritis, and discuss the possible multiple pathogenic reasons behind this.
Watanabe R et al. Curr Treat Options in Rheum 2016;2:126. doi:10.1007/s40674-016-0043-x
Recognising that although epigenetic studies in vasculitis are still in their infancy, the authors review the most recent data on these mechanisms to better understand the pathogenesis of this disease.