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Clinical Considerations of Episcleritis and Scleritis

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The Sclera

Abstract

Episcleritis is a benign disease that presents as an uncomfortable red eye, sometimes with tearing and mild photophobia. Pain, if any, is mild and localized to the eye. Episcleritis rarely causes significant adverse ocular sequelae and is infrequently associated with systemic disease. Unlike episcleritis, scleritis is a severe inflammatory disease that can be progressively destructive, sometimes leading to loss of vision or loss of the eye. It presents with deep, severe pain, often radiating to the forehead, the jaw, and the sinuses. Scleritis is often associated not only with ocular complications (keratitis, uveitis, glaucoma, and cataract if anterior or fundus abnormalities if posterior), but also with immune-mediated systemic diseases, some of them potentially lethal.

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References

  1. Fraunfelder FT, Watson PG. Evaluation of eyes enucleated for scleritis. Br J Ophthalmol. 1976;60:227.

    PubMed  CAS  Google Scholar 

  2. Watson PG, Hayreh SS. Scleritis and episcleritis. Br J Ophthalmol. 1976;60:163.

    PubMed  CAS  Google Scholar 

  3. Watson PG, Hazleman BL. The sclera and systemic disorders. Philadelphia: W.B. Saunders Company; 1976.

    Google Scholar 

  4. Watson PG. Doyne Memorial Lecture, 1982. The nature and the treatment of scleral inflammation. Trans Ophthalmol Soc UK. 1982;102(257):1982.

    Google Scholar 

  5. Watson PG. Diseases of the sclera and episclera. In: Tasman W, Jaeger EA, editors. Duane’s clinical ophthalmology, rev ed. Philadelphia: J. B. Lippincott; 1989.

    Google Scholar 

  6. Wilhelmus KR, Watson PG, Vasavada AR. Uveitis associated with scleritis. Trans Ophthalmol Soc UK. 1981;101:351.

    PubMed  Google Scholar 

  7. Calthorpe CM, Watson PG, McCartney ACE. Posterior scleritis: a clinical and histopatological survey. Eye. 1988;2:267.

    PubMed  Google Scholar 

  8. Cleary PE, Watson PG. Visual loss due to posterior segment disease in scleritis. Trans Ophthalmol Soc UK. 1975;95:297.

    PubMed  CAS  Google Scholar 

  9. Wilhelmus KR, Grierson I, Watson PG. Histopathologic and clinical associations of scleritis and glaucoma. Am J Ophthalmol. 1981;91:697.

    PubMed  CAS  Google Scholar 

  10. Lyons CJ, Hakin KN, Watson PG. Topical Flurbiprofen: an effective treatment for episcleritis? Eye. 1990;4:521.

    PubMed  Google Scholar 

  11. Meyer PA, Watson PG, Franks W, Dubord P. “Pulsed” immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease. Eye. 1987;1:487.

    PubMed  Google Scholar 

  12. Hayreh SS, Watson PG. Prednisolone-21-stearoylglycolate in scleritis. Br J Ophthalmol. 1970;54:394.

    PubMed  CAS  Google Scholar 

  13. Tuft SJ, Watson PG. Progression of scleral disease. Ophthalmology. 1991;98:467.

    PubMed  CAS  Google Scholar 

  14. Williamson J. Incidence of eye disease in cases of connective tissue disease. Trans Ophthalmol Soc UK. 1974;94:742.

    PubMed  CAS  Google Scholar 

  15. Heinonen O. Über Episcleritis periodica fugax und Erblichkeit. Acta Ophthalmol. 1923;1:166.

    Google Scholar 

  16. Heinonen O. Nachtrag zu meiner Arbeit “Über episcleritis periodica fugax und Erblichkeit”. Acta Ophthalmol. 1927;4:278.

    Google Scholar 

  17. Lyne AJ, Pitkeathley DA. Episcleritis and scleritis. Arch Ophthalmol. 1968;80:171.

    PubMed  CAS  Google Scholar 

  18. McGavin DD, Williamson J, Forrester JV, et al. Episcleritis and scleritis: a study of their clinical manifestations and association with rheumatoid arthritis. Br J Ophthalmol. 1976;60:192.

    PubMed  CAS  Google Scholar 

  19. Watson PG, McKay DA, Clemett RS, et al. Treatment of episcleritis. A double blind trial comparing betamethasone 0.1%, oxyphenbutazone 10% and placebo eye ointments. Br J Ophthalmol. 1973;57:866.

    PubMed  CAS  Google Scholar 

  20. Campbell DM. Episcleritis. Ophthal Rec. 1903;12:517.

    Google Scholar 

  21. Duke-Elder S, Leigh AG. Diseases of the outer eye. Cornea and sclera. In: Duke-Elder S, editor. System of ophthalmology, vol 8, pt 2. St Louis: CV Mosby; 1965.

    Google Scholar 

  22. James DG. Erythema nodosum. Br Med J. 1961;1:853.

    PubMed  CAS  Google Scholar 

  23. Beerman H. Erythema nodosum. Am J Med Sci. 1952;223:433.

    PubMed  CAS  Google Scholar 

  24. McCarthy JL. Episcleral nodules and erythema nodosum. Am J Ophthalmol. 1961;51:60.

    PubMed  CAS  Google Scholar 

  25. Friedman AH, Henkind P. Unusual causes of episcleritis. Trans Am Acad Ophthalmol Otolaryngol. 1967;71:303.

    Google Scholar 

  26. Margo CE. Recurrent episcleritis and emotional stress. Arch Ophthalmol. 1984;102:821.

    PubMed  CAS  Google Scholar 

  27. Rahe RH. Subjects’ recent life changes and their near-future illness susceptibility. Adv Psychosom Med. 1972;8:2.

    PubMed  CAS  Google Scholar 

  28. Obermayer M. Psychocutaneous medicine. Springfield: Thomas Publisher; 1955.

    Google Scholar 

  29. Weiner H, Thaler M, Reiser MF, et al. Etiology of duodenal ulcer. Psychosom Med. 1957;19:1.

    PubMed  CAS  Google Scholar 

  30. Engel GL. Studies of ulcerative colitis: III. The nature of the psychology process. Am J Med. 1955;19:231.

    PubMed  CAS  Google Scholar 

  31. Rothfield N. Clinical features of systemic lupus erythematosus. In: Kelley WN, Harris ED, Ruddy S, Sledge CB, editors. Textbook of rheumatology. 3rd ed. Philadelphia: W.B. Saunders Company; 1989.

    Google Scholar 

  32. Palmblad J. Stress and immunologic competence: studies in man. In: Ader R, editor. Psychoneuroimmunology. New York: Academic; 1981. p. 229–57.

    Google Scholar 

  33. Ader R. A historical account of conditioned immunobiologic responses. In: Ader R, editor. Psychoneuroimmunology. New York: Academic; 1981. p. 323–45.

    Google Scholar 

  34. Benedict WL. Etiology and treatment of scleritis and episcleritis. Trans Amer Acad Ophthalmol Otolaryngol. 1924;29:211.

    Google Scholar 

  35. Moench LM. Gynaecologic foci in relation to scleritis and episcleritis and other ocular infections. Am J Med Sci. 1927;174:439.

    Google Scholar 

  36. Villard E. Episclérite cataméniale. Arch Ophtalmol. 1930;47:534.

    Google Scholar 

  37. Paufique L, Etienne R. L’étiologie génitale de quelques affections oculaires chez la femme. Arch Ophtalmol. 1949;9:157.

    CAS  Google Scholar 

  38. Drouet P, Thomas C. Episclérite periodique et ­système endocrino-vegatif. Bull Soc d’Ophtalmol France. 1952;7:682.

    Google Scholar 

  39. Zondek B, Bromberg YM. Endocrine allergy. Clinical reactions of allergy to endogenous hormones and their treatment. J Obstet Gynaecol Br Emp. 1947;54:1.

    PubMed  CAS  Google Scholar 

  40. Balyeat RM. Scleritis due to allergy. J Am Med Assoc. 1932;98:2054.

    Google Scholar 

  41. Sinskey HL, Levin MB, Sacks B. Episcleritis—a new method of approach. Arch Ophthalmol. 1921;50:526.

    Google Scholar 

  42. Shoemaker WA. Episcleritis. Am J Ophthalmol. 1924;7:468.

    Google Scholar 

  43. Watson PG. The diagnosis and management of scleritis. Ophthalmology. 1980;87:716.

    PubMed  CAS  Google Scholar 

  44. Sainz de la Maza M, Tauber J, Foster CS. Scleral grafting for necrotizing scleritis. Ophthalmology. 1989;96:306.

    PubMed  CAS  Google Scholar 

  45. Foster CS, Forstot SL, Wilson LA. Mortality rate in rheumatoid arthritis patients developing necrotizing scleritis or peripheral ulcerative keratitis. Ophthalmology. 1984;91:1253.

    PubMed  CAS  Google Scholar 

  46. Scott DGI, Bacon PA, Tribe CR. Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine. 1981;60:288.

    PubMed  CAS  Google Scholar 

  47. Scott DGI, Bacon PA, Allen C, et al. IgG rheumatoid factor, complement, and immune complexes in rheumatoid synovitis and vasculitis: comparative and serial studies during cytotoxic therapy. Clin Exp Immunol. 1981;43:54.

    PubMed  CAS  Google Scholar 

  48. Sokoloff L, Bunim JJ. Vascular lesions in rheumatoid arthritis. J Chronic Dis. 1957;5:668.

    PubMed  CAS  Google Scholar 

  49. Douglas W. The digital artery lesion of rheumatoid arthritis. Ann Rheum Dis. 1965;24:40.

    PubMed  CAS  Google Scholar 

  50. Ferguson RH, Slocumb CH. Peripheral neuropathy in rheumatoid arthritis. Bull Rheum Dis. 1961;11:251.

    PubMed  CAS  Google Scholar 

  51. Hunder GG, McDuffie FC. Hypocomplementemia in rheumatoid arthritis. Am J Med. 1973;54:461.

    PubMed  CAS  Google Scholar 

  52. Collins DH. The subcutaneous nodule of rheumatoid arthritis. J Pathol Bacteriol. 1937;45:97.

    Google Scholar 

  53. Bennett GA, Zeller JW, Bauer W. Subcutaneous nodules of rheumatoid arthritis and rheumatic fever: a pathologic study. Arch Pathol. 1940;30:70.

    Google Scholar 

  54. Kaye BR, Kaye RL, Bobrove A. Rheumatoid nodules. Review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases. Am Rheum Dis. 1964;23:345.

    Google Scholar 

  55. Fong LP, Sainz de la Maza M, Rice BA, et al. Immunopathology of scleritis. Ophthalmology. 1991;98:472.

    PubMed  CAS  Google Scholar 

  56. van der Hoeve J. Scleromalacia perforans. Ned T Geneesk. 1931;75:4733.

    Google Scholar 

  57. Roca PD. Necrotising (rheumatoid) disease of the sclera. N Y State J Med. 1974;74:1982.

    PubMed  CAS  Google Scholar 

  58. van der Hoeve J. Scleromalacia perforans. Arch Ophthalmol. 1934;11:111.

    Google Scholar 

  59. Wojno Z. Ein Fall von forschreitender Erweichung der Lederhaut. Klin Oczna. 1935;13:778.

    Google Scholar 

  60. Kiehle FA. Scleromalacia. Am J Ophthalmol. 1937;20:565.

    Google Scholar 

  61. Urrets Zavalia A, Maldonado AI, Obregon OR. Skero­malazie in Verlauf einer chronischen Prophyrinurie. Klin Monatsbl f Augenh. 1937;99:189.

    Google Scholar 

  62. Verhoeff FH, King MJ. Scleromalacia perforans. Report of a case in which the eye was examined microscopically. Arch Ophthalmol. 1938;20:1013.

    Google Scholar 

  63. Franceschetti A, Bischler V. La sclérite nodulaire nécrosante et ses rapports avec la scléromalacie. Ann d’Oc. 1950;183:737.

    CAS  Google Scholar 

  64. François J. Scleromalacie perforante. Bull de la Soc Belge d’Ophthalmol. 1950;96:694.

    Google Scholar 

  65. Ashton N, Hobbs HE. Effect of cortisone on rheumatoid nodules of the sclera (scleromalacia perforans). Br J Ophthalmol. 1952;36:373.

    PubMed  CAS  Google Scholar 

  66. Rosenthal JW, Williams GT. Scleromalacia perforans as a complication of rheumatoid arthritis. Am J Ophthalmol. 1962;54:862.

    PubMed  CAS  Google Scholar 

  67. Anderson B, Margolis C. Scleromalacia: clinical and pathologic study of a case with consideration of differential diagnosis, relationship of collagen disease, and effect of ACTH and cortisone therapy. Am J Ophthalmol. 1952;35:917.

    PubMed  CAS  Google Scholar 

  68. Arkle JS, Ingram HV. Scleromalacia perforans. Trans Ophthalmol Soc UK. 1935;55:552.

    Google Scholar 

  69. François J. Scleromalacia perforans, arthritis deformans and pemphigus. Trans Ophthalmol Soc UK. 1951;71:61.

    Google Scholar 

  70. Sorensen TB. Paralimbal scleromalacia. Acta Ophthalmol. 1975;53:901.

    CAS  Google Scholar 

  71. Mader TH, Stulting RD, Crosswell HH. Bilateral paralimbal scleromalacia perforans. Am J Ophthalmol. 1990;109:233.

    PubMed  CAS  Google Scholar 

  72. Sena JA, Cereboni FC. Scleral excavations. Arch Oftalmol Buenos Aires. 1948;23:313.

    Google Scholar 

  73. Kyrieleis W. Ueber umschriebenen Lederhautschwund (Sleromalazie) in hoeheren Lebensalter. Klin Monatsbl f Augenh. 1939;103:441.

    Google Scholar 

  74. Kiss J. Fall von seniler Sklerverdunnung. Klin Monatsbl f Augenh. 1934;92:121.

    Google Scholar 

  75. Roper KL. Senile hyaline scleral plaques. Arch Ophthalmol. 1945;34:283.

    CAS  Google Scholar 

  76. Graves B. Bilateral mesial superficial deficiency of the sclera: scleral plaques. Br J Ophthalmol. 1941;25:35.

    PubMed  CAS  Google Scholar 

  77. Katz D. A localized area of calcareous degeneration in the sclera. Arch Ophthalmol. 1929;2:30.

    Google Scholar 

  78. Culler AM. The pathology of scleral plaques: report of 5 cases of degenerative plaques in the sclera mesially, one studied histologically. Br J Ophthalmol. 1939;23:44.

    PubMed  CAS  Google Scholar 

  79. Drescher EP, Henderson JW. Senile hyaline scleral plaques: report of 3 cases. Proc Mayo Clin. 1949;24:334.

    CAS  Google Scholar 

  80. Holloway TB, Fry WE. Unsuspected brawny scleritis in a case of retinal detachment with secondary glaucoma. Arch Ophthalmol. 1931;6:36.

    Google Scholar 

  81. Howard GM. Erroneous clinical diagnoses of retinoblastoma and uveal melanoma. Trans Am Acad Ophthalmol Otolaryngol. 1969;73:199.

    PubMed  CAS  Google Scholar 

  82. Feldon SE, Singleman J, Albert DM, Smith TR. Clinical manifestations of brawny scleritis. Am J Ophthalmol. 1978;85:781.

    PubMed  CAS  Google Scholar 

  83. Yeo JH, Jakobiek FA, Iwamoto T, Brown R, Harrison W. Metastatic carcinoma masquerading as scleritis. Ophthalmology. 1983;90:184.

    PubMed  CAS  Google Scholar 

  84. Benson WE, Shields JA, Tasman W, Crandall AS. Posterior scleritis. A cause of diagnostic confusion. Arch Ophthalmol. 1979;97:1482.

    PubMed  CAS  Google Scholar 

  85. Singh G, Guthoff R, Foster CS. Observations on longterm follow-up of posterior scleritis. Am J Ophthalmol. 1986;101:570.

    PubMed  CAS  Google Scholar 

  86. Benson WE. Posterior scleritis. Surv Ophthalmol. 1988;32:297.

    PubMed  CAS  Google Scholar 

  87. Blodi FC, Gass JD. Inflammatory pseudotumor of the orbit. Br J Ophthalmol. 1968;52:79.

    PubMed  CAS  Google Scholar 

  88. Rootman J, Nugent R. The classification and management of acute orbital pseudotumors. Ophthalmology. 1982;89:1040.

    PubMed  CAS  Google Scholar 

  89. Cappaert WE, Purnell EW, Frank KE. Use of B-sector scan ultrasound in the diagnosis of benign choroidal folds. Am J Ophthalmol. 1977;84:375.

    PubMed  CAS  Google Scholar 

  90. Kalina RE, Mills RP. Adquired hyperopia with choroidal folds. Ophthalmology. 1980;87:44.

    PubMed  CAS  Google Scholar 

  91. Sears ML. Choroidal and retinal detachments associated with scleritis. Am J Ophthalmol. 1964;58:764.

    PubMed  CAS  Google Scholar 

  92. Bertelsen TI. Acute sclerotenonitis and ocular myositis complicated by papillitis, retinal detachment and glaucoma. Acta Ophthalmol. 1960;38:136.

    CAS  Google Scholar 

  93. Gass JDM. Differential diagnosis of intraocular tumors. St Louis: CV Mosby; 1974.

    Google Scholar 

  94. Feldon SE, Sigelman J, Albert DM, et al. Clinical manifestations of brawny scleritis. Am J Ophthalmol. 1978;85:781.

    PubMed  CAS  Google Scholar 

  95. Cangemi FE, Trempe CL, Walsh JB. Choroidal folds. Am J Ophthalmol. 1978;86:380.

    PubMed  CAS  Google Scholar 

  96. Newell FW. Choroidal folds. Am J Ophthalmol. 1973;75:930.

    PubMed  CAS  Google Scholar 

  97. Bullock JD, Egbert PR. Experimental choroidal folds. Am J Ophthalmol. 1972;78:618.

    Google Scholar 

  98. Hyavarinen L, Walsh FB. Benign chorioretinal folds. Am J Ophthalmol. 1970;70:14.

    Google Scholar 

  99. Bellows AR, Chylak Jr LT, Hutchinson BT. Choroidal detachment. Clinical manifestation, therapy and mechanism of formation. Ophthalmology. 1981;88:1107.

    PubMed  CAS  Google Scholar 

  100. Quinlan MP, Hitchings RA. Angle-closure glaucoma secondary to posterior scleritis. Br J Ophthalmol. 1978;62:330.

    PubMed  CAS  Google Scholar 

  101. Rochels R, Reis G. Echography in posterior scleritis. Klin Monatsbl Augenheilkd. 1980;177:611.

    PubMed  CAS  Google Scholar 

  102. Mauriello JA, Flanagan JC. Management of orbital inflammatory disease. A protocol. Surv Ophthalmol. 1984;29:104.

    PubMed  Google Scholar 

  103. Trokel SL, Hilal SK. Submillimeter resolution CT scanning of orbital diseases. Ophthalmology. 1980;87:412.

    PubMed  CAS  Google Scholar 

  104. Trokel SL. Computed tomographic scanning of orbital inflammations. Int Ophthalmol Clin. 1982;22(4):81.

    PubMed  CAS  Google Scholar 

  105. Terner IS, Leopold IH, Eisenberg IJ. The radioactive phosphorus (32P) uptake test in ophthalmology. Arch Ophthalmol. 1956;55:52.

    CAS  Google Scholar 

  106. Zakov ZN, Smith TR, Albert DM. False-positive 32P uptake tests. Arch Ophthalmol. 1978;96:2240.

    PubMed  CAS  Google Scholar 

  107. Shields JA. Accuracy and limitations of the P32 test in the diagnosis of ocular tumors: an analysis of 500 cases. Ophthalmology. 1978;85:950.

    PubMed  CAS  Google Scholar 

  108. Norton EWD. A characteristic fluorescein angiographic pattern in choroidal folds. Proc R Soc Med. 1969;62:119.

    PubMed  CAS  Google Scholar 

  109. Kroll AJ, Norton EWD. Regression of choroidal folds. Trans Am Acad Ophthalmol Otolaryngol. 1970;74:515.

    PubMed  CAS  Google Scholar 

  110. Jakobiec FA, Jones IS. Orbital inflammations. In: Duane T, editor. Clinical ophthalmology, vol. 2. Hagerstown: Harper and Row; 1976. p. 1–75.

    Google Scholar 

  111. Birch-Hirschfeld A. Zur Diagnostik und Pathologic der Orbital- tumoren. Ber Dtsch Ophthal Ges. 1905;32:127.

    Google Scholar 

  112. Jellinek EH. The orbital pseudotumour syndrome and its differentiation from endocrine exophthalmos. Brain. 1969;92:35.

    PubMed  CAS  Google Scholar 

  113. Chavis RM, Garner A, Wright JE. Inflammatory orbital pseudotumor. Arch Ophthalmol. 1978;96:1817.

    PubMed  CAS  Google Scholar 

  114. Heersink B, Rodrigues MR, Flanagan JC. Inflammatory pseudotumor of the orbit. Ann Ophthalmol. 1977;9:17.

    PubMed  CAS  Google Scholar 

  115. Coleman JD, Jack RL, Jones IS, et al. Pseudotumors of the orbit. Arch Ophthalmol. 1972;88:472.

    PubMed  CAS  Google Scholar 

  116. Kennerdell JS, Dressner SC. The nonspecific orbital inflammatory syndromes. Surv Ophthalmol. 1984;29:93.

    PubMed  CAS  Google Scholar 

  117. Sergott RC, Glaser JS. Grave’s ophthalmopathy. A clinical and immunologic review. Surv Ophthalmol. 1981;26:1.

    PubMed  CAS  Google Scholar 

  118. Trokel SL, Jakobiec FA. Correlation of CT scanning and pathologic features of ophthalmic Grave’s ­disease. Ophthalmology. 1981;88:553.

    PubMed  CAS  Google Scholar 

  119. Char DH. Clinical ocular oncology. New York: Churchill Livingstone; 1989. p. 97–108.

    Google Scholar 

  120. Hallden U. Malignant melanoma of the choroid clinically simulating scleritis attended by amotio retinae. Acta Ophthalmol. 1955;33:489.

    CAS  Google Scholar 

  121. Smith LT, Irvine AR. Diagnostic significance of orange pigment accumulation over choroidal tumors. Am J Ophthalmol. 1973;76:212.

    PubMed  CAS  Google Scholar 

  122. Chang S, Dallow RL, Coleman DJ. Ultrasonic evaluation of intraocular tumors. In: Jakobiec FA, editor. Ocular and anexal tumors. Birmingham: Aesculapius Publishing Company; 1978. p. 290–1.

    Google Scholar 

  123. Fraser Jr DJ. Font RL: ocular inflammation and hemorrhage as initial manifestations of uveal malignant melanoma. Incidence and prognosis. Arch Ophthalmol. 1979;97:1311.

    PubMed  Google Scholar 

  124. Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974;92:276.

    PubMed  CAS  Google Scholar 

  125. Yeo JH, Jakobiec FA, Iwamoto T, Brown R, Harrison W. Metastatic carcinoma masquerading as scleritis. Ophthalmology. 1983;90:184.

    PubMed  CAS  Google Scholar 

  126. Witschel H, Font RL. Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature. Surv Ophthalmol. 1976;20:415.

    PubMed  CAS  Google Scholar 

  127. Augsburger JJ, Shields JA, Moffat KP. Circumscribed choroidal hemangiomas: long-term visual prognosis. Retina. 1981;1:56.

    PubMed  CAS  Google Scholar 

  128. Hayreh SS. Choroidal tumors: role of fluorescein fundus angiography in their diagnosis. Curr Concepts Ophthalmol. 1974;4:168.

    Google Scholar 

  129. Gass JDM. Radial chorioretinal folds. A sign of choroidal neovascularization. Arch Ophthalmol. 1981;99:1016.

    PubMed  CAS  Google Scholar 

  130. Nettleship E. Peculiar lines in the choroid in a case of post- papillitic atrophy. Trans Ophthalmol Soc UK. 1884;4:167.

    Google Scholar 

  131. Bird AC, Sanders MD. Choroidal folds in association with papilloedema. Br J Ophthalmol. 1973;57:89.

    PubMed  CAS  Google Scholar 

  132. Gass JDM. Hypotony maculopathy. In: Bellows JC, editor. Comtemporary Ophthalmology, Honoring Sir Stewart Duke-Elder. Baltimore: Williams & Wilkins; 1972. p. 343–66.

    Google Scholar 

  133. Collins ET. Intra-ocular tension. I. The sequelae of hypotony. Trans Ophthalmol Soc UK. 1917;37:281.

    Google Scholar 

  134. Kreiger AE, Meyer D, Smith TR, et al. Metastatic carcinoma to the choroid with choroidal detachment. Arch Ophthalmol. 1969;82:209.

    PubMed  CAS  Google Scholar 

  135. Taake WH, Allen RA, Straatsma BR. Metastasis of a hepatoma to the choroid. Am J Ophthalmol. 1953;56:208.

    Google Scholar 

  136. Schepens CL, Brockhurst RJ. Uveal effusion. I. Clinical picture. Arch Ophthalmol. 1963;70:189.

    PubMed  CAS  Google Scholar 

  137. Gass JDM, Jallow S. Idiopathic serous detachment of the choroid, ciliary body, and retina (uveal effusion syndrome). Ophthalmology. 1982;89:1018.

    PubMed  CAS  Google Scholar 

  138. Wilson RS, Hanna C, Morris MD. Idiopathic chorioretinal effusion: an analysis of extracellular fluids. Ann Ophthalmol. 1977;9:647.

    PubMed  CAS  Google Scholar 

  139. Ohno S, Char DH, Kimura SJ, O’Connor GR. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1977;83:735.

    PubMed  CAS  Google Scholar 

  140. Perry HD, Font RL. Clinical and histopathologic observations in severe Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1977;83:242.

    PubMed  CAS  Google Scholar 

  141. Pattison EM. Uveomeningoencephalitic syndrome (Vogt-Koyanagi-Harada). Arch Neurol. 1965;12:197.

    PubMed  CAS  Google Scholar 

  142. Lubin JR, Loewenstein JI, Frederick AR. Vogt-Koyanagi-Harada syndrome with focal neurologic signs. Am J Ophthalmol. 1981;91:332.

    PubMed  CAS  Google Scholar 

  143. Holt-Wilson AD, Watson PG. Non-syphilitic deep interstitial keratitis associated with scleritis. Trans Ophthalmol Soc UK. 1974;94:52.

    Google Scholar 

  144. Ferry AP, Leopold IH. Marginal (ring) corneal ulcer as a presenting manifestation of Wegener’s granuloma. Trans Am Acad Ophthalmol Otolaryngol. 1970;74:1276.

    PubMed  CAS  Google Scholar 

  145. Brown SI, Grayson M. Marginal furrows: a characteristic corneal lesion of rheumatoid arthritis. Arch Ophthalmol. 1968;79:563.

    PubMed  CAS  Google Scholar 

  146. Eiferman RA, Carothers DJ, Yankeelov JA. Peripheral rheumatoid ulceration and evidence for conjunctival collagenase production. Am J Ophthalmol. 1979;87:703.

    PubMed  CAS  Google Scholar 

  147. Jayson MIV, Easty DL. Ulceration of the cornea in rheumatoid arthritis. Ann Rheum Dis. 1977;36:428.

    PubMed  CAS  Google Scholar 

  148. Scharf Y, Meyer E, Nahir M, Zonis S. Marginal mottling of cornea in rheumatoid arthritis. Ann Ophthalmol. 1984;16:924.

    PubMed  CAS  Google Scholar 

  149. Lyne AJ. “Contact lens” cornea in rheumatoid arthritis. Br J Ophthalmol. 1970;54:410.

    PubMed  CAS  Google Scholar 

  150. Goldman KN, Kaufman HE. Atypical pterygium: a clinical feature of Terrien’s marginal degeneration. Arch Ophthalmol. 1978;96:1027.

    PubMed  CAS  Google Scholar 

  151. Etzine S, Friedmann A. Marginal dystrophy of the cornea with total ectasia. Am J Ophthalmol. 1963;55:150.

    Google Scholar 

  152. Austin P, Brown SI. Inflammatory Terrien’s marginal corneal disease. Am J Ophthalmol. 1981;92:189.

    PubMed  CAS  Google Scholar 

  153. Krachmer JH. Pellucid marginal corneal degeneration. Arch Ophthalmol. 1978;96:1217.

    PubMed  CAS  Google Scholar 

  154. Krachmer JH, Feder RS, Belin MW. Keratoconus and related non-inflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293.

    PubMed  CAS  Google Scholar 

  155. Friedlander MH, Smolin G. Corneal degenerations. Ann Ophthalmol. 1979;11:1485.

    Google Scholar 

  156. Sugar A. Corneal and conjunctival degenerations. In: Kaufman HE, Barron BA, McDonald MB, Waltman SR, editors. The cornea. New York: Churchill Livingstone; 1988.

    Google Scholar 

  157. Foster CS. Systemic immunosuppressive therapy for progressive bilateral Mooren’s ulcer. Ophthalmology. 1985;92:1436.

    PubMed  CAS  Google Scholar 

  158. Tauber J, Sainz de la Maza M, Hoang-Xuan T, Foster CS. A analysis of therapeutic decision making regarding immunosuppressive chemotherapy for peripheral ulcerative keratitis. Cornea. 1990;9(1):66.

    PubMed  CAS  Google Scholar 

  159. Foster CS. Immunosuppressive therapy for external ocular inflammatory disease. Ophthalmology. 1980;87:140.

    PubMed  CAS  Google Scholar 

  160. Sainz de la Maza M, Foster CS. The diagnosis and treatment of peripheral ulcerative keratitis. Semin Ophthalmol. 1991;6(3):133.

    Google Scholar 

  161. Sainz de la Maza M, Foster CS. Necrotizing scleritis after ocular surgery: a clinicopathologic study. Ophthalmology. 1991;98:1720.

    PubMed  CAS  Google Scholar 

  162. Lyne AJ, Lloyd-Jones D. Necrotizing scleritis after ocular surgery. Tran Ophthalmol Soc UK. 1979;99:146.

    CAS  Google Scholar 

  163. Salamon SM, Mondino BJ, Zaidman GW. Peripheral corneal ulcers, conjunctival ulcers, and scleritis after cataract surgery. Am J Ophthalmol. 1982;93:334.

    PubMed  CAS  Google Scholar 

  164. Kaufman LM, Folk ER, Miller MT, Tessler HH. Necrotizing scleritis following strabismus surgery for thyroid ophthalmolpathy. J Pediatr Ophthalmol Strabismus. 1989;26:236.

    PubMed  CAS  Google Scholar 

  165. Mamalis N, Johnson MD, Haines JM, et al. Corneal-scleral melt in association with cataract surgery and intraocular lenses: A report of four cases. J Cataract Refract Surg. 1990;16:109.

    Google Scholar 

  166. Bloomfield SE, Becker CG, Christian CL, Nauheim JS. Bilateral necrotising scleritis with marginal corneal ulceration after cataract surgery in a patient with vasculitis. Br J Ophthalmol. 1980;64:170.

    PubMed  CAS  Google Scholar 

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Correspondence to Maite Sainz de la Maza MD, PhD .

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de la Maza, M.S., Tauber, J., Foster, C.S. (2012). Clinical Considerations of Episcleritis and Scleritis. In: The Sclera. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6502-8_4

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