Summary
Alcoholic ingestion is one of the major factors for increasing serum uric acid levels. Genotypes of aldehyde dehydrogenase 2 (ALDH2, E.C.1.2.1.3), which regulates the sensitivity of an individual to ethanol, were determined in Japanese patients with gout and control subjects by allele specific oligonucleotide hybridization using PCR amplified gene. The most common allele ALDH2*1 codes for normal ALDH2 activity, while the less common allele ALDH2*2 codes for a lower enzyme activity. The frequency of homozygotes of ALDH2*2 was significantly lower in patients with gout than those with rheumatoid arthritis or a normal population. Plasma and urinary hypoxanthine levels were strikingly increased after ethanol drinking in homozygotes for ALDH2*1 but not in heterozygotes for ALDH2* 1/ALDH2*2, indicated extensive purine nucleotide degradation in homozygote for ALDH2*1. These data indicated that alcohol ingestion may not be the requisite factor but is deeply involved in the pathogenesis of gout and hyperuricemia.
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References
Faller, J. and Fox, LH.: Ethanol-induced hyperuricemia. Evidence for increased urate production by activation of adenine nucleotide turnover. N. Eng. J. Med. 307:1598 (1982).
Lieber, C.S., Jones, D.P., Losowsky, M.S., Davidson, C.S.: Interaction of uric acid and ethanol metabolism in man. J. Clin. Invest. 41:1863 (1962).
Harada, S.S., Misawa, S., Agarwal, D.P., and Goedde, H.W.: Liver aldehyde dehydrogenase in Japanese-isozyme variation and its possible role in alcohol intoxication. Am. J. Hum. Genet. 32:8 (1980).
Yoshida, A., Haung, I-Y. and Ikawa, M. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc. Natl. Acad. Sci. U.S.A. 81:258 (1984).
Crabb, D.W., Edenberg, H.J., Bosron, W.F., and Li, T-K. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. J Clin Invest 83:314 (1989).
Shibuya, A. and Yoshida, A. Frequency of the atypical aldehyde dehydrogenase-2 gene (ALDH2/2) in Japanese and Caucasians. Am. J. Hum. Genet. 43:741 (1988).
Xu, Y., Carr, L.G., Bosron, W.F., Li, T-K and Edenberg, H. Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209 (1988).
Fox, I.H., Pallela, T.D., and Kelley, W.N.: Hyperuricemia: a marker for cell energy crisis. N Engl. J Med 317:111 (1987).
Shibuya, A. and Yoshida, A.: Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver disease: A strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1/2) with the disease. Am J Hum Genet 43:744 (1988).
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Yamanaka, H., Kamatani, N., Hakoda, M., Terai, C., Kawaguchi, R., Kashiwazaki, S. (1995). Analysis of the Genotypes for Aldehyde Dehydrogenase 2 in Japanese Patients with Primary Gout. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_13
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_13
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