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Sodium Channels and Pain

  • Chapter
Pain Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 227))

Abstract

Human and mouse genetic studies have led to significant advances in our understanding of the role of voltage-gated sodium channels in pain pathways. In this chapter, we focus on Nav1.7, Nav1.8, Nav1.9 and Nav1.3 and describe the insights gained from the detailed analyses of global and conditional transgenic Nav knockout mice in terms of pain behaviour. The spectrum of human disorders caused by mutations in these channels is also outlined, concluding with a summary of recent progress in the development of selective Nav1.7 inhibitors for the treatment of pain.

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Authors and Affiliations

  1. Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK

    Abdella M. Habib, John N. Wood & James J. Cox

Authors
  1. Abdella M. Habib
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  2. John N. Wood
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  3. James J. Cox
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Corresponding author

Correspondence to James J. Cox .

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Editors and Affiliations

  1. Institute of Physiology/Neurophysiology, Jena University Hospital, Jena, Thüringen, Germany

    Hans-Georg Schaible

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Habib, A.M., Wood, J.N., Cox, J.J. (2015). Sodium Channels and Pain. In: Schaible, HG. (eds) Pain Control. Handbook of Experimental Pharmacology, vol 227. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46450-2_3

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