Abstract.
Predictors for erosive arthritis in systemic lupus erythematosus (SLE) are poorly understood. We performed a pilot, descriptive case-series study to identify whether different biomarkers differentiate SLE patients from those additionally developing erosive arthritis. Median C-reactive protein (CRP) concentration in erosive arthritis was 14.5 mg/L (IQR, 6.6–19.4), but only 0.8 (0.45–7.37, p = 0.01) in non-erosive. Anti-cyclic citrullinated peptide antibodies (anti- CCP) were also associated with erosive arthritis (60 vs. 0% , p = 0.02; OR = 18.2, 0.66–495). Serum IL-6, IFNγ, IL-4 and IL-10 tended to be higher in erosive arthritis, although none attained statistical significance. A negative correlation between IL-6 and CRP was found in non-erosive arthritis ( r–0.60). High CRP and anti-CCP may be useful serological markers for an erosive arthritis pattern among SLE patients.
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Received 27 May 2008; returned for revision 3 July 2008; received from final revision 18 July 2008; accepted by J. A. Battisto 31 July 2008
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Amezcua-Guerra, L.M., Márquez-Velasco, R. & Bojalil, R. Erosive arthritis in systemic lupus erythematosus is associated with high serum C-reactive protein and anti-cyclic citrullinated peptide antibodies. Inflamm. res. 57, 555–557 (2008). https://doi.org/10.1007/s00011-008-8110-x
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DOI: https://doi.org/10.1007/s00011-008-8110-x