Abstract
Takayasu’s arteritis is a granulomatous giant-cell arteritis of the aorta and its major branches. It primarily affects East Asian women in their second or third decade of life but is well known to affect all ethnicities across the world. Given its systemic nature, Takayasu’s arteritis has multiorgan involvement, with the majority of disease morbidity related to the cardiovascular, central nervous, and renal systems. This report describes an unusual presentation of Takayasu’s arteritis in a 2½-year-old boy. This is the first report in the literature describing the presence of both severe aortic regurgitation and diffuse coronary artery involvement in a patient so young.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amano J, Suzuki A (1991) Coronary artery involvement in Takayasu’s arteritis: collective review and guideline for surgical treatment. J Thorac Cardiovasc Surg 102:554–560
Braunwald E, Zipes DP, Libby P (2001) Heart disease: a textbook of cardiovascular medicine, 6th edn. WB Saunders, Philadelphia, PA, pp 2200–2202
Fadi S, Robert PG, Gregory RG (2009) Takayasu arteritis in a young woman. A 4-year case history. Tex Heart Inst J 36:470–474
Hashimoto Y, Tanaka M, Hata A, Kakuta T, Maruyama Y, Numano F (1996) Four years follow-up study in patients with Takayasu arteritis and severe aortic regurgitation: assessment by echocardiography. Int J Cardiol 54(Suppl):S173–S176
Ishikawa K, Maetani S (1994) Long-term outcome for 120 Japanese patients with Takayasu’s disease: clinical and statistical analyses of related prognostic factors. Circulation 90:1855–1860
Johnston SL, Lock RJ, Gompels MM (2002) Takayasu arteritis: a review. J Clin Pathol 55:481–486
Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS (1994) Takayasu arteritis. Ann Intern Med 120:919–929
Lupi-Herrera E, Sanchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE (1977) Takayasu’s arteritis: clinical study of 107 cases. Am Heart J 93:94–103
Maksimowicz-McKinnon K, Clark TM, Hoffman GS (2007) Limitations of therapy and a guarded prognosis in an American cohort of Takayasu arteritis patients. Arthritis Rheum 56:1000–1009
Nakao K, Ikeda M, Kimata S, Niitani H, Niyahara M (1967) Takayasu’s arteritis: clinical report of eighty-four cases and immunological studies of seven cases. Circulation 35:1141–1155
Numano F, Kakuta T (1996) Takayasu arteritis: five doctors in the history of Takayasu arteritis. Int J Cardiol 54(Suppl):S1–S10
Petrovic-Rackov L, Pejnovic N, Jevtic M, Damjanov N (2009) Longitudinal study of 16 patients with Takayasu’s arteritis: clinical features and therapeutic management. Clin Rheumatol 28:179–185
Ravelli A, Pedroni E, Perrone S, Tramarin R, Martini A, Burgio GR (1999) Aortic valve regurgitation as the presenting sign of Takayasu arteritis. Eur J Pediatr 158:281–283
Subramanyan R, Joy J, Balakrishnan KG (1989) Natural history of aortoarteritis (Takayasu’s disease). Circulation 80:429–437
Takayasu M (1908) A case with peculiar changes of the central retinal vessels. Acta Societatis Ophthalmologicae Japonicae Tokyo 12:554
Zheng D, Fan D, Liu L (1992) Takayasu arteritis in China: a report of 530 cases. Heart Vessels Suppl 7:32–36
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Berman, D.P., Lewis, A.B. & Kung, G.C. Case Report of a 2-Year-Old Boy With Takayasu’s Arteritis: An Atypical, Severe Presentation of a Rare Disease. Pediatr Cardiol 31, 1089–1092 (2010). https://doi.org/10.1007/s00246-010-9742-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-010-9742-5