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Effects of cigarette smoking on early arthritis: a cross-sectional study—data from the Argentine Consortium for Early Arthritis (CONAART)

  • Original Article - Epidemiology of RMD
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Abstract

Our objective was to analyze the effects of cigarette smoking on disease activity, functional capacity, radiographic damage, serology and presence of extraarticular manifestations in patients with rheumatoid arthritis and undifferentiated arthritis. This is a cross-sectional study of 1,305 patients (729 with rheumatoid arthritis and 576 with undifferentiated arthritis) from CONAART, the Argentine Consortium for Early Arthritis that includes patients older than 16 years with <2 years of disease. Sociodemographic data, clinical characteristics of the disease and smoking history were collected. In patients with rheumatoid arthritis the disease activity score of 28 joints was 5.4 ± 1.3 in current smokers, 5.2 ± 1.4 in former smokers and 5.1 ± 1.4 in never smokers (p = 0.011). The simple erosion narrowing score was higher in current smokers and former smokers than in never smokers (M 14.0, R Q 6.0–21.0; M 15.0, R Q 7.0–24.0; M 10.0, R Q 5.0–17.0; p = 0.006). Current smokers had higher rheumatoid factor titer (M 160.0, R Q 80.0–341.0) than former smokers (M 146.8, R Q 6.03–255.5) and never smokers (M 15.0, R Q 9.0–80.0) (p = 0.004). The variable independently associated with tobacco exposure was simple erosion narrowing score (OR = 1.03, 95 % CI 1.00–1.05; p = 0.012). In patients with undifferentiated arthritis, an association between smoking status and parameters of activity or radiographic damage was not observed. Neither was tobacco exposure related to the presence of extraarticular manifestations or to the degree of disability in any of the two groups of patients. No relation was found between disease activity and severity, and number of packs smoked per year. Tobacco.

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Acknowledgments

CONAART was supported by Pfizer. The Sponsor did not participate in the collection, analysis and/or interpretation of the data, or in the writing of this manuscript.

Conflict of interest

All authors declare they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Hospital Privado Centro Médico de Córdoba SA, Naciones Unidas 346-B° Parque Vélez Sarsfield, X5016KEH, Córdoba, Argentina

    María Jezabel Haye Salinas, Soledad Retamozo, Ana Cecilia Alvarez & Francisco Caeiro

  2. Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina

    Hernán Maldonado Ficco, Fernando Dal Pra & Gustavo Citera

  3. Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina

    Mariana Benegas, Rafael Chaparro del Moral & Oscar Rillo

  4. Hospital Rivadavia, Buenos Aires, Argentina

    Anastasia Secco, Lucila Marino Claverie & Antonio Catalan Pellet

  5. Hospital General San Martin, La Plata, Argentina

    Josefina Marcos, Mercedes Argentina García & Juan Carlos Marcos

  6. Hospital Padilla, Tucumán, Argentina

    Ana Barbaglia, Verónica Bellomio & Alberto Berman

  7. Hospital Italiano, Buenos Aires, Argentina

    Cristian Quiroz & Enrique R Soriano

  8. Hospital Jose María Cullen, Santa Fe, Argentina

    Federico Ceccato & Sergio Paira

  9. Centro Integral de Reumatología, Tucumán, Argentina

    Doralia Vazquez

  10. Hospital Señor del Milagro, Salta, Argentina

    Vicente Ricardo Juarez

  11. Sanatorio Adventista del Plata Libertador San Martín, Entre Ríos, Argentina

    Edson Javier Velozo

  12. Instituto Provincial de Rehabilitación Integral, Santiago del Estero, Argentina

    Gabriela Salvatierra

Authors
  1. María Jezabel Haye Salinas
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  2. Soledad Retamozo
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  3. Ana Cecilia Alvarez
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  4. Hernán Maldonado Ficco
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  5. Fernando Dal Pra
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  6. Gustavo Citera
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  8. Rafael Chaparro del Moral
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  9. Oscar Rillo
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  10. Anastasia Secco
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  11. Lucila Marino Claverie
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  13. Josefina Marcos
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  14. Mercedes Argentina García
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  15. Juan Carlos Marcos
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  16. Ana Barbaglia
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  17. Verónica Bellomio
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  18. Alberto Berman
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  19. Cristian Quiroz
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  20. Enrique R Soriano
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  21. Federico Ceccato
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  22. Sergio Paira
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  23. Doralia Vazquez
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  24. Vicente Ricardo Juarez
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  25. Edson Javier Velozo
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  26. Gabriela Salvatierra
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  27. Francisco Caeiro
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Corresponding author

Correspondence to María Jezabel Haye Salinas.

Additional information

Marcos Juan Carlos: Deceased.

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Haye Salinas, M.J., Retamozo, S., Alvarez, A.C. et al. Effects of cigarette smoking on early arthritis: a cross-sectional study—data from the Argentine Consortium for Early Arthritis (CONAART). Rheumatol Int 35, 855–859 (2015). https://doi.org/10.1007/s00296-014-3188-7

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  • DOI: https://doi.org/10.1007/s00296-014-3188-7

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