Skip to main content

Advertisement

SpringerLink
Log in

Vitamin D levels in juvenile idiopathic arthritis from an equatorial region

  • Original Article - Observational Research
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

We aimed to describe the serum levels of 25-hydroxyvitamin D (25OHD) in juvenile idiopathic arthritis (JIA) patients living in a low-latitude (3°43′S) region. Fifty JIA patients, 31 (62 %) female, seen between May 2012 and April 2013 in the northeast of Brazil had clinical data and serum collected for determination of 25OHD and parathyroid hormone (PTH) using a chemiluminescent ELISA; 20 age- and sex-matched controls were used for comparison. Mean age was 13.4 ± 4 years. Twenty-five (50 %), 15 (30 %), 4 (8 %), 4 (8 %), and 2 (4 %) patients were of the polyarticular, oligoarticular, systemic, enthesitis-related, and undifferentiated categories, respectively. Mean 25OHD was 31.6 ± 10 and 30.4 ± 5.7 ng/mL in patients and controls (P > 0.05), respectively; PTH was normal in JIA and controls; 25OHD was similar regardless of JIA category, disease activity, or severity measured by JADAS-27, CHAQ, or presence of joint deformities. Twenty-six (52 %), 20 (40 %), and 4 (8 %) patients were considered to have optimal, sufficient, and deficient 25OHD levels, respectively, whereas 11 (52 %) and 10 (48 %) controls had optimal and sufficient 25OHD. Ethnicity, body mass index, seasonal variation, and use of steroids did not influence 25OHD levels. This is the first study on 25OHD levels in JIA patients living in a low-latitude region, showing the lowest prevalence of vitamin D deficiency ever reported. Serum 25OHD was similar in JIA and controls and did not vary regardless of JIA category or severity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Manners PJ, Bower C (2002) Worldwide prevalence of juvenile arthritis why does it vary so much? J Rheumatol 29:1520–1530

    PubMed  Google Scholar 

  2. Terreri MT, Campos LM, Okuda EM, Silva CA, Sacchetti SB, Marini R et al (2013) Profile of paediatric rheumatology specialists and services in the state of São Paulo. Rev Bras Reumatol 53:346–351

    Article  PubMed  Google Scholar 

  3. Yamashita E, Terreri MT, Hilário MO, Len CA (2013) Prevalence of juvenile idiopathic arthritis in children aged 6 to 12 years in Embu das Artes, state of Sao Paulo, Brazil. Rev Bras Reumatol 53:542–545

    Article  PubMed  Google Scholar 

  4. Shapira Y, Agmon-Levin N, Shoenfeld Y (2010) Geoepidemiology of autoimmune rheumatic diseases. Nat Rev Rheumatol 6:468–476

    Article  CAS  PubMed  Google Scholar 

  5. Ellis JA, Munro JE, Ponsonby AL (2010) Possible environmental determinants of juvenile idiopathic arthritis. Rheumatology 49:411–425

    Article  PubMed  Google Scholar 

  6. Cauley JA, Danielson ME, Boudreau R, Barbour KE, Horwitz MJ, Bauer DC et al (2011) Serum 25-hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: the Women’s Health Initiative (WHI). J Bone Miner Res 26:2378–2388

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296:2832–2838

    Article  CAS  PubMed  Google Scholar 

  8. Rossini M, Maddali Bongi S, La Montagna G, Minisola G, Malavolta N, Bernini L et al (2010) Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther 12:R216

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Hong Q, Xu J, Xu S, Lian L, Zhang M, Ding C (2014) Associations between serum 25-hydroxyvitamin D and disease activity, inflammatory cytokines and bone loss in patients with rheumatoid arthritis. Rheumatology 53:1994–2001

    Article  PubMed  Google Scholar 

  10. Cutolo M, Otsa K, Laas K, Yprus M, Lehtme R, Secchi ME et al (2006) Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe. Clin Exp Rheumatol 24:702–704

    CAS  PubMed  Google Scholar 

  11. Pelajo CF, Lopez-Benitez JM, Miller LC (2010) Vitamin D and autoimmune rheumatologic disorders. Autoimmun Rev 9:507–510

    Article  CAS  PubMed  Google Scholar 

  12. Wöbke TK, Sorg BL, Steinhilber D (2014) Vitamin D in inflammatory diseases. Front Physiol 5:244

    PubMed Central  PubMed  Google Scholar 

  13. Nisar MK, Masood F, Cookson P, Sansome A, Ostör AJ (2013) What do we know about juvenile idiopathic arthritis and vitamin D? A systematic literature review and meta-analysis of current evidence. Clin Rheumatol 32:729–734

    Article  PubMed  Google Scholar 

  14. Pelajo CF, Lopez-Benitez JM, Kent DM, Price LL, Miller LC, Dawson-Hughes B (2012) 25-hydroxyvitamin D levels and juvenile idiopathic arthritis: Is there an association with disease activity? Rheumatol Int 32:3923–3929

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Bouaddi I, Rostom S, El Badri D, Hassani A, Chkirate B, Abouqal R et al (2014) Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis. BMC Musculoskelet Disord 15:115

    Article  PubMed Central  PubMed  Google Scholar 

  16. Patel S, Farragher T, Berry J, Bunn D, Silman A, Symmons D (2007) Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis Rheum 56:2143–2149

    Article  CAS  PubMed  Google Scholar 

  17. Turhanoğlu AD, Güler H, Yönden Z, Aslan F, Mansuroglu A, Ozer C (2011) The relationship between vitamin D and disease activity and functional health status in rheumatoid arthritis. Rheumatol Int 31:911–914

    Article  PubMed  Google Scholar 

  18. LeBlanc ES, Zakher B, Daeges M, Pappas M, Chou R (2015) Screening for Vitamin D deficiency: a systematic review for the US preventive services task force. Ann Intern Med 162:109–122

    Article  PubMed  Google Scholar 

  19. Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D et al (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab 86:1212–1221

    Article  CAS  PubMed  Google Scholar 

  20. Ladizesky M, Lu Z, Oliveri B, San Roman N, Diaz S, Holick MF et al (1995) Solar ultraviolet B radiation and photoproduction of vitamin D3 in central and southern areas of Argentina. J Bone Miner Res 10:545–549

    Article  CAS  PubMed  Google Scholar 

  21. Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J et al (2004) International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392

    PubMed  Google Scholar 

  22. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281

    Article  CAS  PubMed  Google Scholar 

  23. Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G et al (2009) Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis Rheum 61:658–666

    Article  PubMed  Google Scholar 

  24. Machado CS, Ruperto N, Silva CH, Ferriani VP, Roscoe I, Campos LM, Oliveira SK, Kiss MH, Bica BE, Sztajnbok F, Len CA, Melo-Gomes JA (2001) The Brazilian version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Paediatric Rheumatology International Trials Organisation. Clin Exp Rheumatol 19(4 Suppl 23):S25–S29

    CAS  PubMed  Google Scholar 

  25. Wallace CA, Ruperto N, Giannini E (2004) Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol 31:2290–2294

    PubMed  Google Scholar 

  26. Consolaro A, Ruperto N, Bracciolini G, Frisina A, Gallo MC, Pistorio A et al (2014) Defining criteria for high disease activity in juvenile idiopathic arthritis based on the juvenile arthritis disease activity score. Ann Rheum Dis 73:1380–1383

    Article  PubMed  Google Scholar 

  27. Stagi S, Bertini F, Cavalli L, Matucci-Cerinic M, Brandi ML, Falcini F (2014) Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis. J Rheumatol 41:1884–1892

    Article  CAS  PubMed  Google Scholar 

  28. Munekata RV, Terreri MT, Peracchi OA, Len C, Lazaretti-Castro M, Sarni RO et al (2013) Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis. Braz J Med Biol Res 46:98–102

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Wagner CL, Greer FR (2008) Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics 122:1142–1152

    Article  PubMed  Google Scholar 

  30. Ravelli A, Martini A (2007) Juvenile idiopathic arthritis. Lancet 369:767–778

    Article  CAS  PubMed  Google Scholar 

  31. Rocha FA, Leite AK, Pompeu MM, Cunha TM, Verri WA Jr, Soares FM et al (2008) Protective effect of an extract from Ascaris suum in experimental arthritis models. Infect Immun 76:2736–2745

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  32. Quinn MA, Emery P (2005) Potential for altering rheumatoid arthritis outcome. Rheum Dis Clin North Am 31:763–772

    Article  PubMed  Google Scholar 

  33. Alcântara AC, Leite CA, Leite AC, Sidrim JJ, Silva FS Jr, Rocha FA (2014) A longterm prospective real-life experience with leflunomide in juvenile idiopathic arthritis. J Rheumatol 41:338–344

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare no conflicts of interest to disclose.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil

    Sâmia Araújo de Sousa Studart, Ana Caroline Rocha Melo Leite, Aryana Lushese Lima Feitosa Marinho, Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes & Francisco Airton Castro Rocha

  2. Rheumatology Service, Pediatric Rheumatology Division, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil

    Carlos Nobre Rabelo Júnior

  3. Department of Public Health, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil

    Hermano Alexandre Lima Rocha

  4. Rua Coronel Nunes de Melo, 1315, Rodolfo Teofilo, Fortaleza, CE, CEP: 60.430-270, Brazil

    Francisco Airton Castro Rocha

Authors
  1. Sâmia Araújo de Sousa Studart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ana Caroline Rocha Melo Leite
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aryana Lushese Lima Feitosa Marinho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ana Carolina Matias Dinelly Pinto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carlos Nobre Rabelo Júnior
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rodolfo de Melo Nunes
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hermano Alexandre Lima Rocha
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Francisco Airton Castro Rocha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Francisco Airton Castro Rocha.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Sousa Studart, S.A., Leite, A.C.R.M., Marinho, A.L.L.F. et al. Vitamin D levels in juvenile idiopathic arthritis from an equatorial region. Rheumatol Int 35, 1717–1723 (2015). https://doi.org/10.1007/s00296-015-3287-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-015-3287-0

Keywords

Search

Navigation